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Spectral CT evaluation of interstitial brachytherapy in pancreatic carcinoma xenografts: preliminary animal experience

  • Hepatobiliary-Pancreas
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Abstract

Objectives

We sought to evaluate the capability of spectral CT to detect the therapeutic response to 125I interstitial brachytherapy in a pancreatic carcinoma xenograft nude mouse model.

Methods

Twenty mice bearing SWl990 human pancreatic cancer cell xenografts were randomly separated into two groups: experimental (n = 10; 1.0 mCi) and control (n = 10; 0 mCi). After a two-week treatment, spectral CT was performed. Contrast-to-noise ratio (CNR) and iodine concentration (IC) in the lesions were measured and normalized to the muscle tissue, and nIC CD31 immunohistochemistry was used to measure microvessel density (MVD). The relationships between the nIC and MVD of the tumours were analysed.

Results

The nIC of the experimental group was significantly lower than that of the control group during the multiphase examination. A significant difference in the MVD was observed between the two groups (P <0.001). The nIC values of the three-phase scans have a certain positive correlation with MVD (r = 0.57, p < 0.0001; r = 0.48, p = 0.002; r = 0.63, p = 0.0017 in the 10, 25, and 60 s phase, respectively).

Conclusions

Spectral CT can be a useful non-invasive imaging modality in evaluating the therapeutic effect of 125I interstitial brachytherapy to a pancreatic carcinoma.

Key Points

• Spectral CT offers opportunities to assess therapeutic response in pancreatic cancer cases.

• Spectral CT findings correlated with vascular changes associated with 125I seed implantation.

• Spectral CT with monochromatic imaging removed most 125I seed artefacts.

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Acknowledgments

The authors wish to thank Dr. Danjun Yuan and Dr. Wenjie Wei for their technical support in editing the manuscript. We especially thank Yixing Yu, Duanmin Hu, and Rongbiao Tang for their contributions.

The scientific guarantor of this publication is Ph.D, M.D Linxiao Zhu. Our authors of this manuscript declare no relationships with any companies. This study was supported in part by a grant-in-aid for scientific research from the Science and Technology Commission of Shanghai Municipality (Project No.11JC1407400,10JC1410900 and 10411953000), the National Natural Science Foundation of China (Project No. 81071281 and 81271682), and the Technology Plan of Zhenjiang (Project No. SH2013083). No complex statistical methods were necessary for this paper. Approval from the institutional animal care committee was obtained. The animal experiments were reviewed and approved by the Official Committee on Animal Affairs of Shanghai Jiao Tong University. Methodology: retrospective, randomised controlled trial/experimental, multicentre study.

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Authors and Affiliations

  1. Department of Radiology, The Affiliated Renmin Hospital, Jiangsu University, Zhenjiang, Jiangsu, 212002, China

    Shudong Hu & Yerong Chen

  2. Department of Radiology, Ruijin Hospital, Shanghai Jiao tong University, School of Medicine, No. 197, Ruijin Er Road, Shanghai, 200025, China

    Shudong Hu, Wei Huang, Qi Song, Xiaozhu Lin, Zhongmin Wang & Kemin Chen

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  1. Shudong Hu
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  2. Wei Huang
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  7. Kemin Chen
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Correspondence to Kemin Chen.

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Hu, S., Huang, W., Chen, Y. et al. Spectral CT evaluation of interstitial brachytherapy in pancreatic carcinoma xenografts: preliminary animal experience. Eur Radiol 24, 2167–2173 (2014). https://doi.org/10.1007/s00330-014-3257-z

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  • DOI: https://doi.org/10.1007/s00330-014-3257-z

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