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Prediction and monitoring of the response to chemoradiotherapy in oral squamous cell carcinomas using a pharmacokinetic analysis based on the dynamic contrast-enhanced MR imaging findings

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Abstract

Objectives

To evaluate whether a pharmacokinetic analysis is useful for both predicting and monitoring the response to chemoradiotherapy (CRT) in oral cancer.

Methods

Patients with oral squamous cell carcinoma treated with preoperative CRT and surgery were enrolled. They underwent dynamic contrast-enhanced MRI before (n = 23), and after CRT (n = 20). We estimated four parameters: arrival time of contrast medium (TA), exchange rate constant from the extracellular extravascular space (EES) to plasma (kep), elimination of contrast medium from the central compartment (kel) and an amplitude scaling constant (AH) using the Brix model. The histological evaluation of the effects of CRT was performed according to Ohboshi and Shimosato’s classification. We analysed the correlation between the parameters and the histological evaluation.

Results

The pre-CRT AH between the responders and non-responders was significantly different (P = 0.046), however, the three parameters (TA, Kep, Kel) were not significantly different among the groups (P = 0.76, P = 0.60, P = 0.09). As AH decreased, the tumour response improved. The change in the AH between the pre- and post-CRT of responders was significantly higher than that of non-responders (P = 0.043).

Conclusion

The AH, which is affected by the ratio of the EES, was an important parameter for predicting and monitoring the tumour response to CRT.

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Acknowledgements

We use a proprietary software program (PRIDE software, Philips Medical Systems) using the interface data language (IDL RSI). One of the authors belongs to Philips Medical Systems.

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Authors and Affiliations

  1. Department of Oral and Maxillofacial Radiology, Faculty of Dental Science, Kyushu University, Maidashi 3-1-1, Higashi-ku, Fukuoka, 812-8582, Japan

    Toru Chikui, Toshiyuki Kawazu & Kazunori Yoshiura

  2. Section of Oral and Maxillofacial Oncology, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University, Fukuoka, Japan

    Shintaro Kawano

  3. Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

    Masamitsu Hatakenaka, Yoshio Matsuo & Syunya Sunami

  4. Radiology Center, Kyushu University Hospital, Kyushu University, Fukuoka, Japan

    Masamitsu Hatakenaka, Syouzou Koga & Masahiro Ohga

  5. Department of Maxillofacial Surgery, Kyushu University Hospital, Kyushu University, Fukuoka, Japan

    Tsuyoshi Sugiura

  6. Department of Heavy Particle Therapy and Radiation Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

    Yoshiyuki Shioyama

  7. Philips Electronics Japan, Ltd 2-13-37, Konan Minato-ku, Tokyo, Japan

    Makoto Obara

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  1. Toru Chikui
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  12. Kazunori Yoshiura
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Correspondence to Toru Chikui.

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Chikui, T., Kawano, S., Kawazu, T. et al. Prediction and monitoring of the response to chemoradiotherapy in oral squamous cell carcinomas using a pharmacokinetic analysis based on the dynamic contrast-enhanced MR imaging findings. Eur Radiol 21, 1699–1708 (2011). https://doi.org/10.1007/s00330-011-2102-x

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  • DOI: https://doi.org/10.1007/s00330-011-2102-x

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