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CT-guided vertebroplasty: analysis of technical results, extraosseous cement leakages, and complications in 500 procedures

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Abstract

The aim of this study was to analyze the technical results, the extraosseous cement leakages, and the complications in our first 500 vertebroplasty procedures. Patients with osteoporotic vertebral compression fractures or osteolytic lesions caused by malignant tumors were treated with CT-guided vertebroplasty. The technical results were documented with CT, and the extraosseous cement leakages and periinterventional clinical complications were analyzed as well as secondary fractures during follow-up. Since 2002, 500 vertebroplasty procedures have been performed on 251 patients (82 male, 169 female, age 71.5 ± 9.8 years) suffering from osteoporotic compression fractures (n = 217) and/or malignant tumour infiltration (n = 34). The number of vertebrae treated per patient was 1.96 ± 1.29 (range 1–10); the numbers of interventions per patient and interventions per vertebra were 1.33 ± 0.75 (range 1–6) and 1.01 ± 0.10, respectively. The amount of PMMA cement was 4.5 ± 1.9 ml and decreased during the 5-year period of investigation. The procedure-related 30-day mortality was 0.4% (1 of 251 patients) due to pulmonary embolism in this case. The procedure-related morbidity was 2.8% (7/251), including one acute coronary syndrome beginning 12 h after the procedure and one missing patellar reflex in a patients with a cement leak near the neuroformen because of osteolytic destruction of the respective pedicle. Additionally, one patient developed a medullary conus syndrome after a fall during the night after vertebroplasty, two patients reached an inadequate depth of conscious sedation, and two cases had additional fractures (one pedicle fracture, one rib fracture). The overall CT-based cement leak rate was 55.4% and included leakages predominantly into intervertebral disc spaces (25.2%), epidural vein plexus (16.0%), through the posterior wall (2.6%), into the neuroforamen (1.6%), into paravertebral vessels (7.2%), and combinations of these and others. During follow-up (15.2 ± 13.4 months) the secondary fracture rate was 17.1%, including comparable numbers for vertebrae at adjacent and distant levels. The presence of intradiscal cement leaks was not associated with increased adjacent fracture rates. CT-guided vertebroplasty is safe and effective for treatment of vertebral compression fractures. CT-fluoroscopy provides an excellent control of the posterior vertebral wall. The number of cement leakages alone is not directly associated with clinical complications. However, even small volumes of pulmonary PMMA embolism might be responsible for the fatal outcome in cases with underlying cardiopulmonary insufficiency.

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Authors and Affiliations

  1. Department of Diagnostic and Interventional Radiology, Johannes Gutenberg-University of Mainz, Langenbeckstrasse 1, 55131, Mainz, Germany

    Michael Bernhard Pitton, Sascha Herber, Ulrike Koch, Katja Oberholzer & Christoph Düber

  2. Department of Orthopedic Surgery, University Hospital, Johannes Gutenberg-University of Mainz, Langenbeckstrasse 1, 55131, Mainz, Germany

    Philip Drees

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  1. Michael Bernhard Pitton
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  2. Sascha Herber
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  3. Ulrike Koch
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  5. Philip Drees
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Correspondence to Michael Bernhard Pitton.

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Pitton, M.B., Herber, S., Koch, U. et al. CT-guided vertebroplasty: analysis of technical results, extraosseous cement leakages, and complications in 500 procedures. Eur Radiol 18, 2568–2578 (2008). https://doi.org/10.1007/s00330-008-1020-z

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  • DOI: https://doi.org/10.1007/s00330-008-1020-z

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