Abstract
To compare the impact of iodine concentration using two different contrast aterials (CM) at standardized iodine delivery rate (IDR) and overall iodine load in 16-multidetector-row-CT-angiography (MDCTA) of the pulmonary arteries of 192 patients with known or suspected pulmonary embolism. One hundred three patients (group A) received 148 ml of a CM containing 300 mg iodine/ml (Ultravist 300™, BayerScheringPharma) at a flow rate of 4.9 ml/s. Eighty-nine patients (group B) received 120 ml of a CM with a concentration of 370 mg iodine/ml (Ultravist370™) at a flow rate of 4.0 ml/s, resulting in a standardized IDR (~1.5 gI/s) and the same overall amount of iodine (44.4 g). Both CM injections were followed by a saline chaser. Mean density values were determined in the pulmonary trunk, the ascending and the descending aorta, respectively. Applying repeated-measures ANOVA, no statistically significant differences between both MDCTA protocols were found (p = 0.5790): the mean density in the pulmonary trunk was 355 ± 116 Hounsfield Units (group A) and 358 ± 115 (group B). The corresponding values for the ascending and descending aorta were 295 ± 79 (group A) and 284 ± 65 (group B) as well as 272 ± 71 and 262 ± 70. In conclusion, the use of standardized IDR and overall iodine load provides comparable intravascular CM density in pulmonary 16-MDCTA for delivering contrast materials with different iodine concentrations.
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Keil, S., Plumhans, C., Behrendt, F.F. et al. MDCT angiography of the pulmonary arteries: intravascular contrast enhancement does not depend on iodine concentration when injecting equal amounts of iodine at standardized iodine delivery rates. Eur Radiol 18, 1690–1695 (2008). https://doi.org/10.1007/s00330-008-0942-9
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DOI: https://doi.org/10.1007/s00330-008-0942-9