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Association study of CD154 polymorphisms and serum CD154 level with systemic lupus erythematous in Chinese population

  • Genes and disease
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Abstract

The aim of this study was to investigate the association of three polymorphisms of CD154 with risk of SLE in Chinese population. The study population comprised 770 Chinese individuals, including 350 SLE patients and 420 healthy controls. The gene polymorphism was measured using Snapshot SNP genotyping assays and confirmed by sequencing. Serum CD154 (sCD154) level was measured by ELISA. Compared with control group, sCD154 levels were significantly increased in case group (P < 0.001). The minor C allele of rs1126535 was associated with a significantly increased risk of SLE as compared to the major T allele (P < 0.001). Furthermore, an increased frequency of C-G-A haplotype was also detected in case group which associated with an increased risk of SLE (P = 0.009). Notably, patients carrying rs1126535CT/CC genotypes had a higher sCD154 level compared with that carrying rs1126535TT genotype (P < 0.05). Unfortunately, analyses on the association between rs1126535 and several clinical manifestations of SLE failed to find any significant results. In conclusion, these results indicated that CD154 gene polymorphisms may associate with the risk of SLE and may play regulation role in the expression of sCD154 in SLE patients.

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Acknowledgements

This study was supported by National Natural Science Foundation of China (No. 81260234, No. 81560552).

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Authors and Affiliations

  1. Department of Clinical Laboratory, The Affiliated Hospital of Youjiang Medical University for Nationalities, 533000, Baise, Guangxi, China

    Yang Xiang, You-Fan Peng, Hua-Tuo Huang & Ye-Sheng Wei

  2. Department of Dermatology, the Affiliated Hospital of Youjiang Medical University for Nationalities, 533000, Baise, Guangxi, China

    Jing Guo & Yan Lan

Authors
  1. Yang Xiang
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  2. Jing Guo
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  3. You-Fan Peng
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  4. Hua-Tuo Huang
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  5. Yan Lan
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Corresponding author

Correspondence to Yan Lan.

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Conflict of interest

Author Yan Lan has received research grants from National Natural Science Foundation of China (grant number 81260234). Author Ye-Sheng Wei has received research grants from National Natural Science Foundation of China (grant number 81560552). All the authors declare that they have no conflict of interest.

Funding

This study was funded by National Natural Science Foundation of China (grant number 81260234, 81560552).

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Informed consent was obtained from all individual participants included in the study.

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Xiang, Y., Guo, J., Peng, YF. et al. Association study of CD154 polymorphisms and serum CD154 level with systemic lupus erythematous in Chinese population. Rheumatol Int 37, 1287–1294 (2017). https://doi.org/10.1007/s00296-017-3745-y

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  • DOI: https://doi.org/10.1007/s00296-017-3745-y

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