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Heterozygote genotypes for PADI4_89 were protectively associated with susceptibility to tuberculosis in Koreans

  • Short Communication - Genes and Disease
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Abstract

The aim of this study was to determine whether peptidyl arginine deiminase (PADI) genes could affect susceptibility to tuberculosis (TB), which can be a presumptive base to explain the increased incidence of TB in patients with rheumatoid arthritis (RA) in Korean. The study population consisted of 47 patients with active TB, 35 patients with nontuberculous mycobacterial disease, 50 RA patients, and 83 healthy controls who had received comprehensive medical testing. Genomic DNA was isolated from peripheral blood mononuclear cells using a standard protocol. All of the patients and healthy controls were genotyped for two nonsynonymous SNPs in PADI4, namely PADI4_89, PADI4_90, and one synonymous SNP in PADI4_104. There was the complete linkage between PADI4_89 and PADI4_90 SNPs. In the allele and haplotype analyses of PADI4_89 and PADI4_104, no significant associations are observed between disease groups and control groups. The frequencies of heterozygote (A/G) for PADI4_89 were significantly lower in patients with active TB than in controls [adjusted odd ratios (OR) = 0.35, p values = 0.020]. When the analysis was conducted by overdominant model, more significant associations are observed (adjusted OR = 0.34, p values = 0.005). We found that heterozygote genotypes for PADI4_89 were protectively associated with susceptibility to TB.

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Acknowledgments

This work was supported by a grant of the Korea Health 21 R&D Project by the Ministry of Health and Welfare (01-PJ3-PG6-01GN09-003), EMBRI Grants 2010-EMBRI DJ 0002 from the Eulji University, and of the Korea Healthcare technology R&D Project, Ministry of Health and Welfare, Republic of Korea (A102065).

Conflict of interest

No potential conflicts of interest were disclosed.

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Authors and Affiliations

  1. Division of Rheumatology, Department of Internal Medicine, Eulji University School of Medicine, 95 Dunsanseo-ro, Seo-gu, Daejeon, 302-799, South Korea

    Mi-Kyoung Lim & Dong-Hyuk Sheen

  2. Department of Pulmonary and Critical Care Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea

    Tae Sun Shim

  3. Department of Preventive Medicine, Eulji University, Daejeon, South Korea

    Mira Park

  4. Division of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea

    Soo-Kon Lee

  5. Department of Laboratory Medicine, Eulji University Hospital, Daejeon, South Korea

    Yong-Hak Sohn

  6. Division of Rheumatology, Daejeon Rheumatoid and Degenerative Arthritis Center, Chungnam National University Hospital, Daejeon, 301-721, South Korea

    Seung-Cheol Shim

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  1. Mi-Kyoung Lim
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  2. Tae Sun Shim
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  3. Mira Park
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  4. Soo-Kon Lee
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  6. Dong-Hyuk Sheen
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  7. Seung-Cheol Shim
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Correspondence to Dong-Hyuk Sheen or Seung-Cheol Shim.

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Lim, MK., Shim, T.S., Park, M. et al. Heterozygote genotypes for PADI4_89 were protectively associated with susceptibility to tuberculosis in Koreans. Rheumatol Int 35, 651–655 (2015). https://doi.org/10.1007/s00296-014-3119-7

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  • DOI: https://doi.org/10.1007/s00296-014-3119-7

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