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Tolerogenic dendritic cells and rheumatoid arthritis: current status and perspectives

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Abstract

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by the influxation of synovia and synovial compartments with immune cells including dendritic cells (DCs). DCs that induce autoimmune tolerance are called tolerogenic DCs (tolDCs). As a promising immunotherapeutic strategy for RA, tolDCs have received increasing attention. In this review, we first introduce the significant role of tolDCs in autoimmune regulation and then describe the manipulation strategies to generate tolDCs; next, we summarize recent progress in the experimental application of tolDCs for RA therapy, and finally we discuss the perspectives of tolerogenic vaccination for the treatment for RA in clinic.

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Acknowledgments

The authors wish to thank Dr. Fu Jinqiu, Tian Zhoubin and Zhao Kai for their review of the manuscript. This work was supported by grant from the National Natural Science Foundation of China (No. 30801258 M.H.) and The Star of Jinan Youth Science and Technology Project (No. 20100114).

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  1. Shandong University, Jinan, Shandong, China

    Yunpeng Zhao, Aijun Zhang & Bin Ning

  2. Cryomedicine Laboratory, Qilu Hospital of Shandong University, Jinan, Shandong, China

    Aijun Zhang

  3. Department of Orthopedic, Jinan Central Hospital Affiliated to Shandong University, Jinan, Shandong, China

    Hongxia Du, Shuya Guo & Bin Ning

  4. Department of Biological Sciences, Wichita State University, Wichita, KS, USA

    Shangyou Yang

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  1. Yunpeng Zhao
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Correspondence to Bin Ning.

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Zhao, Y., Zhang, A., Du, H. et al. Tolerogenic dendritic cells and rheumatoid arthritis: current status and perspectives. Rheumatol Int 32, 837–844 (2012). https://doi.org/10.1007/s00296-011-2133-2

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