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Invasive Mammakarzinome: Die aktuelle WHO-Klassifikation

Invasive breast cancer: the current WHO classification

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Zusammenfassung

Die WHO-Klassifikation der Tumoren der Mamma bildet international die Basis für die Einordnung und Nomenklatur der Tumoren. Die 2012 erschienene 4. Auflage spiegelt unser gegenwärtiges Verständnis zur Klassifikation, Immunhistologie, Differenzialdiagnose und Genetik der Läsionen wider. Verglichen mit der 3. Auflage enthält sie einige Änderungen in der Terminologie. Etablierte Entitäten wurden neu bewertet und zahlreiche molekulare Aspekte wurden hinzugefügt. Dieser Beitrag behandelt die invasiven Karzinome. Die histopathologischen Definitionen der aktuellen WHO-Klassifikation werden durch die Beschreibungen der klinischen, makroskopischen, molekularen sowie prognostischen und prädiktiven Eigenschaften der Tumoren ergänzt.

Abstract

The World Health Organization (WHO) classification of tumors of the breast defines the international standards for tumor categorization and nomenclature. The fourth edition, published in 2012, provides an update on the current knowledge concerning the classification, immunohistology profile, differential diagnosis and genetics of these lesions. Compared to the previous edition, some terms have been modified, some entities were reclassified and some current molecular data have been added. This article focuses on invasive carcinomas. Definitions for histological diagnosis are supplemented by clinical, macroscopic and molecular characteristics as well as prognostic and predictive features.

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Einhaltung ethischer Richtlinien

Interessenkonflikt A. Lebeau, M. Kriegsmann, E. Burandt, H.-P. Sinn geben an, dass kein Interessenkonflikt besteht. Dieser Beitrag beinhaltet keine Studien an Menschen oder Tieren.

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Authors and Affiliations

  1. Institut für Pathologie, Universitätsklinikum Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Deutschland

    A. Lebeau & E. Burandt

  2. Gemeinschaftspraxis für Pathologie, Lübeck, Deutschland

    A. Lebeau

  3. Institut für Pathologie, Universitätsklinikum Heidelberg, Heidelberg, Deutschland

    M. Kriegsmann & H.-P. Sinn

  4. Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, USA

    E. Burandt

Authors
  1. A. Lebeau
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  2. M. Kriegsmann
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  3. E. Burandt
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  4. H.-P. Sinn
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Correspondence to A. Lebeau.

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Lebeau, A., Kriegsmann, M., Burandt, E. et al. Invasive Mammakarzinome: Die aktuelle WHO-Klassifikation. Pathologe 35, 7–17 (2014). https://doi.org/10.1007/s00292-013-1841-7

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