Skip to main content
SpringerLink
Log in

A sandwich electrospun nanofibers/Tragacanth hydrogel composite containing Aloe vera extract and silver sulfadiazine as a wound dressing

  • ORIGINAL PAPER
  • Published:
Polymer Bulletin Aims and scope Submit manuscript

Abstract

In the present study, a sandwich electrospun nanofibers/tragacanth hydrogel composite containing Aloe vera extract and silver sulfadiazine was prepared. The potential application was considered as a wound dressing. The first layer was prepared from polyacrylonitrile (PAN) by electrospinning method with thick diameter. The second layer was prepared by spraying a thin layer of tragacanth gum (TG) hydrogel containing silver sulfadiazine (SSD) and Aloe vera (AV) on the electrospun nanofibers. The properties of the electrospun nanofibers were evaluated by Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM). In addition, other properties such as mechanical properties, swelling ratio, cell viability were evaluated. SEM micrographs show smooth, beadles nanofibers, and a uniform layer of hydrogel was sprayed on the nanofibers. Adding 10% Aloe vera to TG increased the percentage of swelling compared to unmodified samples. Nanofibers have strong mechanical properties. The Young’s modulus of sandwich dressing was increased. The cytotoxicity assay of a sandwich electrospun nanofibers/tragacanth hydrogel composite shows that it has no cytotoxicity toward human dermal fibroblasts (HDF), therefore confirming their cytocompatibility.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6

Similar content being viewed by others

References

  1. Jayakumar R, Prabaharan M, Kumar PS, Nair S, Tamura H (2011) Biomaterials based on chitin and chitosan in wound dressing applications. Biotechnol Adv 29:322–337

    Article  CAS  PubMed  Google Scholar 

  2. Boateng J, Catanzano O (2015) Advanced therapeutic dressings for effective wound healing—a review. J Pharm Sci 104:3653–3680

    Article  CAS  PubMed  Google Scholar 

  3. Liu X, Liu Y, Du J, Li X, Yu J, Ding B (2021) Breathable, stretchable and adhesive nanofibrous hydrogels as wound dressing materials. Eng Regen 2:63–69

    Google Scholar 

  4. Zhang M, Chen S, Zhong L, Wang B, Wang H, Hong F (2020) Zn2+-loaded TOBC nanofiber-reinforced biomimetic calcium alginate hydrogel for antibacterial wound dressing. Int J Biol Macromol 143:235–242

    Article  CAS  PubMed  Google Scholar 

  5. Hosseini MS, Hemmati K, Ghaemy M (2016) Synthesis of nanohydrogels based on tragacanth gum biopolymer and investigation of swelling and drug delivery. Int J Biol Macromol 82:806–815

    Article  Google Scholar 

  6. Cho C, Leung K (2007) In vitro and in vivo immunomodulating and immunorestorative effects of Astragalus membranaceus in murine models and in tumor-bearing mice. In: AACR

  7. Bagheri SM, Keyhani L, Heydari M, Dashti-R MH (2015) Antinociceptive activity of Astragalus gummifer gum (gum tragacanth) through the adrenergic system: a in vivo study in mice. J Ayurveda Integr Med 6:19

    Article  PubMed  PubMed Central  Google Scholar 

  8. Majumder R, Das CK, Mandal M (2019) Lead bioactive compounds of Aloe vera as potential anticancer agent. Pharmacol Res 148:104416

    Article  CAS  PubMed  Google Scholar 

  9. Dat AD, Poon F, Pham KB, Doust J (2012) Aloe vera for treating acute and chronic wounds. Cochrane Database Syst Rev

  10. Khan AW, Kotta S, Ansari SH, Sharma RK, Kumar A, Ali J (2013) Formulation development, optimization and evaluation of Aloe vera gel for wound healing. Pharmacogn Mag 9:S6

    Article  PubMed  PubMed Central  Google Scholar 

  11. Ajmera N, Chatterjee A, Goyal V (2013) Aloe vera: it’s effect on gingivitis. J Indian Soc Periodontol 17:435

    Article  PubMed  PubMed Central  Google Scholar 

  12. Rahmanian-Schwarz A, Beiderwieden A, Willkomm L-M, Amr A, Schaller H-E, Lotter O (2011) A clinical evaluation of Biobrane® and Suprathel® in acute burns and reconstructive surgery. Burns 37:1343–1348

    Article  PubMed  Google Scholar 

  13. Akhoondinasab MR, Akhoondinasab M, Saberi M (2014) Comparison of healing effect of Aloe vera extract and silver sulfadiazine in burn injuries in experimental rat model. World J Plast Surg 3:29

    PubMed  PubMed Central  Google Scholar 

  14. Pandey A, Momin M, Chando A (2020) Silver sulfadiazine loaded breathable hydrogel sponge for wound healing. Drug Metab Pers Ther 35

  15. Fu Q, Duan C, Yan Z, Li Y, Si Y, Liu L, Yu J, Ding B (2018) Nanofiber-based hydrogels: controllable synthesis and multifunctional applications. Macromol Rapid Commun 39:1800058

    Article  Google Scholar 

  16. Guo Y, Drum J, Qu C, Cakmak M (2016) Mechanical reinforcement of hydrogels by nanofiber network undergoing biaxial deformation. Polym Compos 37:709–717

    Article  CAS  Google Scholar 

  17. Ghosh T, Das T, Purwar R (2021) Review of electrospun hydrogel nanofiber system: synthesis, properties and applications. Polym Eng Sci 61:1887–1911

    Article  CAS  Google Scholar 

  18. Chen KS, Ku YA, Lee CH, Lin HR, Lin FH, Chen TM (2005) Immobilization of chitosan gel with cross-linking reagent on PNIPAAm gel/PP nonwoven composites surface. Mater Sci Eng C 25:427–478

    Article  CAS  Google Scholar 

  19. Jirofti N, Golandi M, Movaffagh J, Ahmadi FS, Kalalinia F (2021) Improvement of the wound-healing process by curcumin-loaded chitosan/collagen blend electrospun nanofibers: in vitro and in vivo studies. ACS Biomater Sci Eng 7:3886–3897

    Article  CAS  PubMed  Google Scholar 

  20. Mahmood H, Khan IU, Asif M, Khan RU, Asghar S, Khalid I, Khalid SH, Irfan M, Rehman F, Shahzad Y (2021) In vitro and in vivo evaluation of gellan gum hydrogel films: assessing the co impact of therapeutic oils and ofloxacin on wound healing. Int J Biol Macromol 166:483–495

    Article  CAS  PubMed  Google Scholar 

  21. Socrates G (2004) Infrared and Raman characteristic group frequencies: tables and charts. John Wiley & Sons, London

    Google Scholar 

  22. Pujana MA, Pérez-Álvarez L, Iturbe LCC, Katime I (2013) Biodegradable chitosan nanogels crosslinked with genipin. Carbohydr Polym 94:836–842

    Article  Google Scholar 

  23. Touyama R, Takeda Y, Inoue K, Kawamura I, Yatsuzuka M, Ikumoto T, Shingu T, Yokoi T, Inouye H (1994) Studies on the blue pigments produced from genipin and methylamine. I. Structures of the brownish-red pigments, intermediates leading to the blue pigments. Chem Pharm Bull 42:668–673

    Article  CAS  Google Scholar 

  24. Dimida S, Barca A, Cancelli N, De Benedictis V, Raucci MG, Demitri C (2017) Effects of genipin concentration on cross-linked chitosan scaffolds for bone tissue engineering: structural characterization and evidence of biocompatibility features. Int J Polym Sci

  25. Jithendra P, Rajam AM, Kalaivani T, Mandal AB, Rose C (2013) Preparation and characterization of Aloe vera blended collagen-chitosan composite scaffold for tissue engineering applications. ACS Appl Mater Interfaces 5:7291–7298

    Article  CAS  PubMed  Google Scholar 

  26. Shao W, Liu H, Liu X, Wang S, Wu J, Zhang R, Min H, Huang M (2015) Development of silver sulfadiazine loaded bacterial cellulose/sodium alginate composite films with enhanced antibacterial property. Carbohydr Polym 132:351–358

    Article  CAS  PubMed  Google Scholar 

  27. Taymouri S, Hashemi S, Varshosaz J, Minaiyan M, Talebi A (2021) Fabrication and evaluation of hesperidin loaded polyacrylonitrile/polyethylene oxide nanofibers for wound dressing application. J Biomater Sci Polym Ed 32:1944–1965

    Article  CAS  PubMed  Google Scholar 

  28. Jadbabaei S, Kolahdoozan M, Naeimi F, Ebadi-Dehaghani H (2021) Preparation and characterization of sodium alginate–PVA polymeric scaffolds by electrospinning method for skin tissue engineering applications. RSC Adv 11:30674–30688

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  29. Shesan OJ, Stephen AC, Chioma AG, Neerish R, Rotimi SE (2019) Fiber-matrix relationship for composites preparation. IntechOpen, London

    Book  Google Scholar 

  30. Baghaie S, Khorasani MT, Zarrabi A, Moshtaghian J (2017) Wound healing properties of PVA/starch/chitosan hydrogel membranes with nano Zinc oxide as antibacterial wound dressing material. J Biomater Sci Polym Ed 28:2220–2241

    Article  CAS  PubMed  Google Scholar 

  31. Bialik-Wąs K, Pluta K, Malina D, Majka TM (2021) Alginate/PVA-based hydrogel matrices with Echinacea purpurea extract as a new approach to dermal wound healing Inter. J Polym Mater Polym Biomater 70:195–206

    Article  Google Scholar 

  32. Ma H, Yu J, Liu L, Fan Y (2021) An optimized preparation of nanofiber hydrogels derived from natural carbohydrate polymers and their drug release capacity under different pH surroundings. Carbohydr Polym 265:118008

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgements

The authors gratefully acknowledge the research council of Kermanshah University of Medical Sciences (Grant No. 4010132) for financial support. This work was performed in partial fulfillment of the requirement for Pharm.D of Mareyeh Eskandari, in the faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Author information

Authors and Affiliations

  1. Nano Drug Delivery Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, 6734667149, Iran

    Hosna Alvandi, Mehdi Jaymand, Faranak Aghaz & Elham Arkan

  2. Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran

    Marie Eskandari

  3. Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran

    Leila Hosseinzadeh

  4. Department of General Surgery, Faculty of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran

    Mohammadbagher Heydari

Authors
  1. Hosna Alvandi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Mehdi Jaymand
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Marie Eskandari
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Faranak Aghaz
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Leila Hosseinzadeh
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Mohammadbagher Heydari
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Elham Arkan
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Elham Arkan.

Ethics declarations

Conflict of interest

The authors declare that they have no conflict of interest.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Alvandi, H., Jaymand, M., Eskandari, M. et al. A sandwich electrospun nanofibers/Tragacanth hydrogel composite containing Aloe vera extract and silver sulfadiazine as a wound dressing. Polym. Bull. 80, 11235–11248 (2023). https://doi.org/10.1007/s00289-022-04603-6

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00289-022-04603-6

Keywords

Search

Navigation