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Recent advances in preparation of polymer hydrogel composites and their applications in enzyme immobilization

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Abstract

Hydrogels as three-dimensional crosslinked polymer networks are widely used in biomedical applications such as tissue engineering scaffolds, wound dressing, contact lenses, drug delivery systems, and cell or enzyme immobilization. Hydrogels are used as efficient matrixes for immobilization of various enzymes and improve their stability over a wide range of operational conditions that make them suitable for several industrial applications. The performance of hydrogels in enzyme immobilization depends on some parameters of the network structure involving the molecular weight of the polymer chain, the polymer volume fraction in the swollen state, and the corresponding mesh size. This review summarizes the recent developments of the synthetic approaches for the preparation of the natural and synthetic hydrogel composites applied for the immobilization of various enzymes. Moreover, the opportunities and challenges associated with hydrogel-based enzyme carriers are discussed and the future perspectives are drawn for applying natural and synthetic hydrogel composites in enzyme immobilization.

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Authors and Affiliations

  1. Department of Biology, Parand Branch, Islamic Azad University, Parand, Iran

    Masoud Salehipour

  2. Pharmaceutical Sciences Research Center, Hemoglobinopathy Institute, Mazandaran University of Medical Sciences, P.O. Box 48175-861, Sari, 4847193698, Iran

    Shahla Rezaei & Mehdi Mogharabi-Manzari

  3. School of Chemical Engineering, College of Engineering, University of Tehran, Tehran, 14176, Iran

    Mahsa Yazdani

  4. Department of Biomedical Engineering, State University of New York at Buffalo, Buffalo, NY, 14260, USA

    Mahsa Yazdani

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Salehipour, M., Rezaei, S., Yazdani, M. et al. Recent advances in preparation of polymer hydrogel composites and their applications in enzyme immobilization. Polym. Bull. 80, 5861–5896 (2023). https://doi.org/10.1007/s00289-022-04370-4

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