Abstract
Oligoaniline (OANI) was prepared using chemical oxidative method using ascorbic acid as a dopant and ammonium persulfate as an oxidant. As-synthesized OANI was subjected for the preparation of various drug composites. All the synthesized compounds were characterized by FTIR, 1HNMR, TGA, GPC, etc. The thermal stability of the compounds was determined by TGA. The molecular weight was determined by GPC. Antibacterial studies of the synthesized compounds were investigated against four Gram-positive (Staphylococcus aureus MTCC 96, Streptococcus pyogenes MTCC 442, B. subtilis MTCC 441 and S. mutans MTCC 890) and four Gram-negative (Escherichia coli MTCC 443, Pseudomonas aeruginosa MTCC 1688, KL. pneumoniae MTCC 109 and S. typhi MTCC 98) bacteria based on their clinical and pharmacological importance. Some of the synthesized compounds showed excellent antibacterial activity as compared to individual bacterial activity of OANI and drugs to be used for preparation of composites.
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Acknowledgements
The financial support provided by University Grants Commission, New Delhi, India, to one of the authors (Gunjan Kashyap) is gratefully acknowledged. Authors are also thankful to SICART Vallabh Vidyanagar and SAIF, Chandigarh, for analytical and spectral data. We are also thankful to Microcare Laboratory, Surat, for biological screening of synthesized compounds.
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Funding was provided by CSIR/UGC-SRF (No.F.2(UGC/JRF/MLSU/2017/2755).
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Kashyap, G., Meghwal, K., Ameta, C. et al. Synthesis of ascorbic acid-doped oligoaniline, its drug composites and study of their antibacterial behavior. Polym. Bull. 76, 2439–2451 (2019). https://doi.org/10.1007/s00289-018-2502-z
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DOI: https://doi.org/10.1007/s00289-018-2502-z