Skip to main content
SpringerLink
Log in

Microwave-assisted synthesis and characterization of polyacrylamide grafted co-polymers of Mimosa mucilage

  • Original paper
  • Published:
Polymer Bulletin Aims and scope Submit manuscript

Abstract

Response surface methodology was applied to optimize the microwave-assisted graft co-polymerization of acrylamide on Mimosa pudica seed mucilage. The effect of variables, microwave power and time of exposure, concentrations of acrylamide, mucilage and ammonium persulfate on grafting efficiency of graft co-polymerization was screened using Plackett–Burman experimental design. The results revealed that the concentration of acrylamide and mucilage are the most significant variables, which were further optimized using, a central composite design. A second-order polynomial equation fitted to the data was used to predict the response in the optimal region. The optimal grafting parameters provided graft co-polymer with grafting efficiency close to the predicted values. The proposed mathematical model is found to be robust and accurate for graft co-polymerization of acrylamide and Mimosa mucilage consistent with goals of maximizing grafting efficiency. The results of FT-IR, DSC, XRD, and SEM studies confirmed the formation of graft co-polymer of acrylamide and Mimosa mucilage.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

References

  1. Bhardwaj TR, Kanwar M, Lal R, Gupta A (2000) Natural gums and modified natural gums as sustained release carriers. Drug Dev Ind Pharm 26:1025–1038

    Article  CAS  Google Scholar 

  2. Trease GE, Evans MC (2002) Textbook of pharmacognosy, 15th edn. Balliere, Tindall, London, p 195

    Google Scholar 

  3. Odeku OA, Patani BO (2005) Evaluation of dika nut mucilage (Irvingia gabonensis) as binding agent in metronidazole tablet formulations. Pharm Dev Technol 10:439–446

    CAS  Google Scholar 

  4. Anroop B, Ghosh B, Parcha V, Vasanti S (2006) Studies on Ocimum gratissimum seed mucilage: evaluation of binding properties. Int J Pharm 325:191–193

    Article  CAS  Google Scholar 

  5. Ghule BV, Darwhekar GD, Jain DK, Yeole PG (2006) Evaluation of binding properties of Eulophia campestris Wall. mucilage. Indian J Pharm Sci 68:566–569

    Article  Google Scholar 

  6. Anroop B, Bhatnagar SP, Ghosh B, Parcha V (2005) Studies on Ocimum gratissimum seed mucilage: evaluation of suspending properties. Indian J Pharm Sci 67:206–209

    CAS  Google Scholar 

  7. Prajapati ST, Prajapati VD, Acharya SR, Patel CN (2006) Characterization of disintegration properties of Plantago ovata mucilage in the formulation of dispersible tablets. Indian J Pharm Edu Res 40:208–211

    Google Scholar 

  8. Baveja SK, Rangarao KV, Jagdish A (1988) Examination of natural gums and mucilages as sustaining materials in tablet dosage forms. Indian J Pharm Sci 50:89–92

    CAS  Google Scholar 

  9. Singh K, Kumar A, Langyan N, Ahuja M (2009) Evaluation of Mimosa pudica seed mucilage as sustained release excipient. AAPS PharmSciTech 10:1121–1127

    Article  CAS  Google Scholar 

  10. Ei-Tahlawy KF, Ei-Rafie SM, Aly AS (2006) Preparation and application of the chitosan/poly(methacrylic acid) graft copolymer. Carbohydr Polym 66:176–183

    Article  Google Scholar 

  11. Mishra A, Yadav A, Pal S, Singh A (2006) Biodegradable graft copolymers of fenugreek mucilage and polyacrylamide: a renewable reservoir to biomaterials. Carbohydr Polym 65:58–63

    Article  CAS  Google Scholar 

  12. Mishra A, Pal S (2007) Polyacrylonitrile-grafted okra mucilage: a renewable reservoir to polymeric materials. Carbohydr Polym 68:95–100

    Article  CAS  Google Scholar 

  13. Mishra A, Rajani S, Agarwal M, Dubey RP (2002) Psyllium-g-polyacrylamide: synthesis and characterization. Polym Bull 48:439–444

    Article  CAS  Google Scholar 

  14. Mishra A, Rajani S, Gupta RP (2003) Psyllium-g-polyacrylonitrile: synthesis and characterization. Colloid Polym Sci 281:187–189

    Article  CAS  Google Scholar 

  15. Mishra A, Bajpai M (2005) Synthesis and characterization of polyacrylamide grafted copolymers of kundoor mucilage. J Appl Polym Sci 98:1186–1191

    Article  CAS  Google Scholar 

  16. Mishra A, Bajpai M (2006) Graft copolymerization of polyacrylamide onto tamarind mucilage. J Macromol Sci A 43:315–326

    CAS  Google Scholar 

  17. Kumar A, Singh K, Ahuja M (2009) Xanthan-g-polyacrylamide: synthesis, characterization and in vitro release behaviour. Carbohydr Polym 76:261–267

    Article  CAS  Google Scholar 

  18. Singh V, Sethi R, Tewari A, Srivastava V, Sanghi R (2003) Hydrolysis of plant seed gums by microwave irradiation. Carbohydr Polym 54:523–525

    Article  CAS  Google Scholar 

  19. Singh V, Tewari A, Tripathi DN, Sanghi R (2004) Microwave assisted synthesis of guar-g-polyacrylamide. Carbohydr Polym 58:1–6

    Article  CAS  Google Scholar 

  20. Athawale VD, Lele V (1998) Graft co-polymerization onto starch. II. Grafting of acrylic acid and preparation of its hydrogels. Carbohydr Polym 35:21–27

    Article  CAS  Google Scholar 

  21. Vanaja K, Shobha Rani RH (2007) Design of experiment concept and application of Plackett–Burman design. Clin Res Regul Aff 24:1–23

    Article  Google Scholar 

  22. Singh B, Kumar R, Ahuja N (2005) Optimizing drug delivery systems using systematic design of experiments, Part I: fundamental aspects. Crit Rev Ther Drug Carrier Syst 22:27–105

    Article  CAS  Google Scholar 

  23. Singh V, Tripathi DN, Tiwari A, Sanghi R (2006) Microwave synthesized chitosan graft–poly(methylmethacrylate): an efficient Zn2+ ion binder. Carbohydr Polym 65:35–41

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Drug Delivery Research Laboratory, Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology, Hisar, 125001, Haryana, India

    Munish Ahuja, Sumit Kumar & Monika Yadav

Authors
  1. Munish Ahuja
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Sumit Kumar
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Monika Yadav
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Munish Ahuja.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ahuja, M., Kumar, S. & Yadav, M. Microwave-assisted synthesis and characterization of polyacrylamide grafted co-polymers of Mimosa mucilage. Polym. Bull. 66, 1163–1175 (2011). https://doi.org/10.1007/s00289-010-0341-7

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00289-010-0341-7

Keywords

Search

Navigation