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Synergism of Nikkomycin Z in Combination with Diphenyl Diselenide Against Sporothrix spp.

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Abstract

We evaluated the in vitro activity of nikkomycin Z (NikZ) in combination with diphenyl diselenide (PhSe)2, two compounds previously shown to have anti-Sporothrix spp. activity. Eighteen isolates of Sporothrix spp. were tested in checkerboard assays. Synergism for inhibition and killing Sporothrix spp. occurred in 100% and 89% of the isolates, respectively. The anti-Sporothrix spp. activity of this combination provides a rationale for in vivo studies to evaluate the application of both compounds in sporotrichosis treatment.

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Acknowledgements

The authors are grateful to the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), this work was accomplished with support from the CAPES- Brazil, within the scope of the Capes-PrInt Program—Financing Code 001.

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Authors and Affiliations

  1. Programa de Pós Graduação Em Ciências da Saúde, Faculdade de Medicina (FAMED), Universidade Federal Do Rio Grande (FURG), Rio Grande, RS, Brazil

    Vanice Rodrigues Poester, Lívia Silveira Munhoz, Jéssica Louise Benelli & Melissa Orzechowski Xavier

  2. Hospital Universitário Dr. Miguel Riet Corrêa Jr. - HU- FURG/Empresa brasileira de serviços hospitalares – Ebserh, Rio Grande, RS, Brazil

    Jéssica Louise Benelli

  3. Programa de Pós Graduação Em Bioquímica Toxicológica, Universidade Federal de Santa Maria (UFSM), Santa Maria, RS, Brazil

    Cristina Wayne Nogueira & Gilson Rogério Zeni

  4. California Institute for Medical Research, San Jose, CA, USA

    David A. Stevens & David Larwood

  5. Division of Infectious Diseases and Geographic Medicine, Stanford University Medical School, Stanford, CA, USA

    David A. Stevens

  6. Valley Fever Solutions, Tucson, AZ, USA

    David Larwood

  7. Laboratório de Micologia, FAMED, FURG, Campus Saúde. Visconde de Paranaguá 102, Centro, Rio Grande, RS, 96201-900, Brazil

    Vanice Rodrigues Poester, Lívia Silveira Munhoz, Gabriel Baracy Klafke & Melissa Orzechowski Xavier

Authors
  1. Vanice Rodrigues Poester
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  2. Lívia Silveira Munhoz
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  3. Jéssica Louise Benelli
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  4. Gabriel Baracy Klafke
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  5. Cristina Wayne Nogueira
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  6. Gilson Rogério Zeni
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  7. David A. Stevens
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  8. David Larwood
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  9. Melissa Orzechowski Xavier
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Contributions

All authors contributed to accomplishment of this manuscript. VRP: Study design; development and methodology; data analysis; and first draft of the manuscript. LSM: Development and methodology; and data analysis. JLB: Development and methodology; and data analysis. GBK: Development and methodology. CWN: Data analysis and manuscript revision. GRZ: Development and methodology and manuscript revision. DAS: Study design; development and methodology; and manuscript revision. DL: Development and methodology; and manuscript revision. MOX: Study design; data analysis; and manuscript revision.

Corresponding author

Correspondence to Melissa Orzechowski Xavier.

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Conflict of interest

All authors declare that they have no conflicts of interest pertaining to this work.

Ethical approval

This study is part of a project approved by the Ethics Committee in Health Area (CEP) from the FURG (CEP FURG: 234/2018).

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Poester, V.R., Munhoz, L.S., Benelli, J.L. et al. Synergism of Nikkomycin Z in Combination with Diphenyl Diselenide Against Sporothrix spp.. Curr Microbiol 78, 2905–2909 (2021). https://doi.org/10.1007/s00284-021-02581-y

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  • DOI: https://doi.org/10.1007/s00284-021-02581-y

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