Abstract
Gene inactivation data have documented that erythropoietin, G-CSF, M-CSF and thrombopoietin are major regulators in vivo respectively of red cell, neutrophil, macrophage and platelet production. Transgenic mice can provide valuable models for observing the consequences of excessive stimulation by a particular growth factor but are subject to variation based on the use of differing promoters for the inserted gene.
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The work from the author’s laboratory was supported by the Carden Fellowship Fund of the Anti-Cancer Council of Victoria, the National Health and Medical Research Council, Canberra, the Cooperative Research Centre for Cellular Growth Factors and the NIH Bethesda, Grant No. CA-22556.
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Metcalf, D. Suppression or overexpression of genes encoding myeloid growth factors or their receptors. Hematol Cell Ther 39, 98–101 (1997). https://doi.org/10.1007/s00282-997-0098-0
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DOI: https://doi.org/10.1007/s00282-997-0098-0