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Immune cell-mediated liver injury

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Abstract

Liver diseases represent an important cause of morbidity and mortality in the world. Death of hepatocytes and other hepatic cell types is a characteristic feature of several forms of liver injury such as cholestasis, viral hepatitis, drug- or toxin-induced injury, and alcohol-induced liver damage. Moreover, irrespectively of the reason, liver injury seems to be facilitated by similar immune effector mechanisms common to these various liver diseases. Indeed, common immune effector mechanisms may explain the high prevalence of cirrhosis and cancer development in most forms of liver disease. Improved understanding of the immune cell-mediated mechanisms involved in hepatocyte cell death could be beneficial for the development of common therapeutic strategies against different forms of liver diseases. In this review, we will discuss novel findings on the role of different immune cells in liver disease and immune cell-induced death executioner mechanisms involved in hepatocyte cell death.

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Acknowledgments

Supported by grant from the Swiss National Science Foundation and Fondazione Ettore e Valeria Rossi (to N. Corazza).

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  1. Division of Immunopathology, Institute of Pathology, University of Bern, Murtenstrasse 31, P.O. Box 62, Bern, 3010, Switzerland

    Nadia Corazza, Anastasia Badmann & Christoph Lauer

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  1. Nadia Corazza
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  2. Anastasia Badmann
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  3. Christoph Lauer
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Correspondence to Nadia Corazza.

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Corazza, N., Badmann, A. & Lauer, C. Immune cell-mediated liver injury. Semin Immunopathol 31, 267–277 (2009). https://doi.org/10.1007/s00281-009-0168-1

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