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Sunitinib malate

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Abstract

Recently, there has been a growing interest in understanding the role of receptor tyrosine kinases (RTK), such as vascular endothelial growth factor receptor (VEGFR), platelet-derived growth factor receptor (PDGFR), stem cell factor receptor (KIT), and fms-like tyrosine kinase 3 (FLT3), in promoting tumor angiogenesis, tumor growth and metastasis. Sunitinib (sunitinib malate; SU11248; SUTENT®; Pfizer Inc, New York, NY, USA) is a novel, orally bio-available, oxindole, multi-targeted tyrosine kinase inhibitor with high binding affinity for VEGFR and PDGFR which has shown anti-tumor and anti-angiogenic activities. This drug recently received approval from the US Food and Administration (FDA) in two indications simultaneously: advanced renal cell carcinoma (adRCC) and gastrointestinal stromal tumors (GIST), in patients who are resistant or intolerant to the treatment with imatinib. The present article reviews the recent pharmacologic and clinical data related to the use of this new promising drug in the field of oncology.

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Authors and Affiliations

  1. Department of Nephrology, Pitie-Salpetriere Hospital 83, Blvd de l’Hôpital, 75013, Paris, France

    Hassane Izzedine & Gilbert Deray

  2. Department of Internal Medicine, Worcester Medical Center, Worcester, MA, USA

    Irina Buhaescu

  3. Department of Clinical Oncology, Pitie-Salpetriere Hospital, Paris, France

    Olivier Rixe

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  1. Hassane Izzedine
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  2. Irina Buhaescu
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  3. Olivier Rixe
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Correspondence to Hassane Izzedine.

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Izzedine, H., Buhaescu, I., Rixe, O. et al. Sunitinib malate. Cancer Chemother Pharmacol 60, 357–364 (2007). https://doi.org/10.1007/s00280-006-0376-5

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