Abstract
Transient abnormal myelopoiesis (TAM) is a haematological complication found in Down syndrome. To determine the mechanisms of sustained proliferation of TAM cells, we studied the expression of apoptosis-related proteins, such as bcl-2, Fas (APO-1/CD95) and p-53, in peripheral blood cells from a new-born infant with Down syndrome and TAM. Using flow cytometry, peripheral blood mononuclear cells (PBMCs), consisting mostly of blast cells, showed marked expression of bcl-2 protein but not of Fas or p-53 products. DNA gel electrophoresis of PBMCs, cultured in the absence of serum factors, revealed no marked fragmentation. Our findings suggest that bcl-2 overexpression may be associated with prolonged cell survival of TAM cells.
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Received: 8 March 1999 / Accepted: 9 November 1999
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Yoshioka, K., Yamamoto, S., Moriguchi, N. et al. Overexpression of bcl-2 in transient abnormal myelopoiesis associated with Down syndrome. Ann Hematol 79, 319–321 (2000). https://doi.org/10.1007/s002779900138
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DOI: https://doi.org/10.1007/s002779900138