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Leukemia and mitophagy: a novel perspective for understanding oncogenesis and resistance

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Abstract

Mitophagy, the selective autophagic process that specifically degrades mitochondria, serves as a vital regulatory mechanism for eliminating damaged mitochondria and maintaining cellular balance. Emerging research underscores the central role of mitophagy in the initiation, advancement, and treatment of cancer. Mitophagy is widely acknowledged to govern mitochondrial homeostasis in hematopoietic stem cells (HSCs), influencing their metabolic dynamics. In this article, we integrate recent data to elucidate the regulatory mechanisms governing mitophagy and its intricate significance in the context of leukemia. An in-depth molecular elucidation of the processes governing mitophagy may serve as a basis for the development of pioneering approaches in targeted therapeutic interventions.

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  1. Department of Pediatrics, West China Second University Hospital, Sichuan University, Sichuan Province, No. 20, Section 3, Renmin South Road, Chengdu, 610041, China

    Yueyao Liu & Zhigui Ma

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L.Y.Y. and M.Z.G. conceptualized this review. L.Y.Y. wrote the manuscript text and prepared Figs. 1–3. M.Z.G. revised the review. All authors read the final manuscript and approved the submission.

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Correspondence to Zhigui Ma.

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Liu, Y., Ma, Z. Leukemia and mitophagy: a novel perspective for understanding oncogenesis and resistance. Ann Hematol (2024). https://doi.org/10.1007/s00277-024-05635-w

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