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Clinical outcomes in patients with diffuse large B cell lymphoma with a partial response to first-line R-CHOP chemotherapy: prognostic value of secondary International Prognostic Index scores and Deauville scores

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A Correction to this article was published on 16 December 2019

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Abstract

After introducing a rituximab-containing chemoimmunotherapy (R-CHOP) for diffuse large B cell lymphoma (DLBCL), a partial response (PR) which is regarded as treatment failure is still observed. To investigate the prognostic factors for the DLBCL patients with a PR to R-CHOP, we retrospectively evaluated 758 newly diagnosed DLBCL patients. After R-CHOP, 88 (11.6%) achieved a PR. Three-year progression-free and overall survival rates measured from the date of PR achievement (PFS2 and OS2) were 57.4 and 67.8%, respectively. The secondary International Prognostic Index (IPI2) scores after R-CHOP were low (0–1) in 68.2% and high (2–3) in 31.8% of the patients. The Deauville scores from 18-fluorodeoxyglucose positron emission tomography after R-CHOP showed low (2–3) in 58.0% and high (4) in 42.0% of the patients. High IPI2 and high Deauville scores were associated with worse PFS2 (P < 0.001 and P = 0.009) and OS2 (P = 0.013 and P = 0.067). The high-risk group defined by the IPI2 and Deauville scores, whose scores were both high, showed significantly lower 3-year PFS2 (P < 0.001) and OS2 (P = 0.006) rates compared with those of the other groups. In multivariate analyses, the IPI score of ≥ 3 at diagnosis and bone marrow involvement at diagnosis were independent prognostic factors. In addition, high IPI2-Deauville score after R-CHOP was significantly associated with poor PFS2 (P = 0.009) and demonstrated a trend toward inferior OS2. In conclusion, DLBCL patients who partially responded to R-CHOP are still a heterogeneous group, for which IPI2 and Deauville scores should be evaluated for prediction of prognosis.

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Change history

  • 16 December 2019

    An additional affiliation for the first author was not indicated. Hyewon Lee is also affiliated with: Department of Internal Medicine, Yonsei University College of Medicine, Gangnam Severance Hospital, Seoul, South Korea.

  • 16 December 2019

    An additional affiliation for the first author was not indicated. Hyewon Lee is also affiliated with: Department of Internal Medicine, Yonsei University College of Medicine, Gangnam Severance Hospital, Seoul, South Korea.

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Acknowledgements

This study was accepted and presented in the form of a poster presentation at the 58th annual meeting of the American Society of Hematology, San Diego, CA, December 3–6, 2016.

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Authors and Affiliations

  1. Center for Hematologic Malignancy, National Cancer Center, Goyang, South Korea

    Hyewon Lee & Hyeon-Seok Eom

  2. Department of Internal Medicine, Yonsei University College of Medicine, Gangnam Severance Hospital, Seoul, South Korea

    Yu Ri Kim

  3. Division of Hematology, Department of Internal Medicine, Yonsei University College of Medicine, Severance Hospital, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, South Korea

    Soo-Jeong Kim & Jin Seok Kim

  4. Division of Hematology-Oncology, Department of Internal Medicine, Korea University College of Medicine, Seoul, South Korea

    Yong Park

  5. Department of Internal Medicine, Dong-A University College of Medicine, Busan, South Korea

    Sung Yong Oh

  6. Division of Hematology-Oncology, Department of Internal Medicine, College of Medicine, Hallym University, Hallym University Sacred Heart Hospital, Anyang, South Korea

    Hyo Jung Kim

  7. Division of Hematology-Oncology, Department of Internal Medicine, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, Seoul, South Korea

    Hye Jin Kang

  8. Division of Hematology-Oncology, Department of Internal Medicine, Busan Paik Hospital, Inje University College of Medicine, Busan, South Korea

    Won-Sik Lee

  9. Department of Hematology and Medical Oncology, Kyungpook National University Hospital, Daegu, South Korea

    Joon Ho Moon

  10. Department of Internal Medicine, Hanyang University College of Medicine, Seoul, South Korea

    Young-Woong Won

  11. Department of Nuclear Medicine, National Cancer Center, Goyang, South Korea

    Tae-Sung Kim

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  1. Hyewon Lee
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Correspondence to Jin Seok Kim.

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Lee, H., Kim, Y.R., Kim, SJ. et al. Clinical outcomes in patients with diffuse large B cell lymphoma with a partial response to first-line R-CHOP chemotherapy: prognostic value of secondary International Prognostic Index scores and Deauville scores. Ann Hematol 96, 1873–1881 (2017). https://doi.org/10.1007/s00277-017-3107-6

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