Skip to main content

Advertisement

SpringerLink
Log in

Successful treatment of calcineurin inhibitor-induced pain syndrome with acute graft versus host disease by switching calcineurin inhibitors followed by pregabalin

  • Letter to the Editor
  • Published:
Annals of Hematology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Refferences

  1. Grotz WH, Breitenfeldt MK, Braune SW, Allmann KH, Krause TM, Rump JA, Schollmeyer PJ (2001) Calcineurin-inhibitor induced pain syndrome (CIPS): a severe disabling complication after organ transplantation. Transpl Int 14:16–23

    Article  CAS  PubMed  Google Scholar 

  2. Yamamoto H, Uchida N, Yuasa M et al (2016) A novel reduced-toxicity myeloablative conditioning regimen using full-dose busulfan, fludarabine, and melphalan for single cord blood transplantation provides durable engraftment and remission in nonremission myeloid malignancies. Biol Blood Marrow Transplant 22:1844–1850

    Article  CAS  PubMed  Google Scholar 

  3. Bechstein WO (2000) Neurotoxicity of calcineurin inhibitors: impact and clinical management. Transpl Int 13:313–326

    Article  CAS  PubMed  Google Scholar 

  4. Kida A, Ohashi K, Kobayashii T, Sakai M, Yamashita T, Akiyama H, Kishida S, Sakamaki H (2004) Incapacitating lower limb pain syndrome in cord blood stem cell transplant recipients with calcineurin inhibitor. Pathol Oncol Res 10:204–206

    Article  PubMed  Google Scholar 

  5. Kakihana K, Ohashi K, Murata Y, Tsubokura M, Kobayashi T, Yamashita T, Sakamaki H, Akiyama H (2012) Clinical features of calcineurin inhibitor-induced pain syndrome after allo-SCT. Bone Marrow Transplant 47:593–595

    Article  CAS  PubMed  Google Scholar 

  6. Patel R, Dickenson AH (2016) Mechanisms of the gabapentinoids and alpha 2 delta-1 calcium channel subunit in neuropathic pain. Pharmacol Res Perspect 4:e00205

    Article  PubMed  PubMed Central  Google Scholar 

  7. Taşoğlu Ö, Gökcan H, Demir SÖ, Yenigün D, Akdoğan M, Kaçar S (2016) Pregabalin: a new adjunct in calcineurin inhibitor pain syndrome treatment. Prog Transplant 26:224–226

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Hematology, Hyogo Prefectural Amagasaki General Medical Center, 2-17-77 Higashinaniwa-cho, Amagasaki, Hyogo, Japan

    Mitsumasa Watanabe, Yusuke Koba & Akira Tamekane

Authors
  1. Mitsumasa Watanabe
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Yusuke Koba
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Akira Tamekane
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Mitsumasa Watanabe.

Ethics declarations

Conflicts of interest

The authors declare no conflicts of interest.

This study was approved by the institutional review board and was conducted in accordance with the Declaration of Helsinki. Informed consent was obtained from the patient included in the study.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Watanabe, M., Koba, Y. & Tamekane, A. Successful treatment of calcineurin inhibitor-induced pain syndrome with acute graft versus host disease by switching calcineurin inhibitors followed by pregabalin. Ann Hematol 96, 1207–1208 (2017). https://doi.org/10.1007/s00277-017-3019-5

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00277-017-3019-5

Keywords

Search

Navigation