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Outcome of HLA-matched related allogeneic hematopoietic stem cell transplantation for patients with acute leukemia in first complete remission treated in Eastern European centers. Better results in recent years

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Abstract

The goal of this study was to analyze results and to determine factors affecting outcome of HLA-matched hematopoetic stem cells transplantation (MRD-HSCT) for patients with acute leukemia transplanted in first complete remission in Eastern European countries. Six hundred forty HSCT were performed between 1990 and 2006 for adults with acute myeloid (n = 459) and lymphoblastic (n = 181) leukemia. Two-year leukemia-free survival (LFS), nonrelapse mortality (NRM), and relapse incidence were 58 ± 2%, 19 ± 2%, and 23 ± 2%, respectively. The cumulative incidence of NRM decreased from 22 ± 2% for patients treated between 1990 and 2002 to 15 ± 3% for transplantations performed between 2003 and 2006 (p = 0.02), despite increasing recipient age. In a multivariate analysis, time of HSCT affected both NRM and LFS. Among other prognostic factors, the use of TBI decreased relapse incidence and increased the LFS rate. We conclude that results of MRD-HSCT for acute leukemia in Eastern Europe improved over time as a consequence of decreased NRM. The use of TBI containing regimens appears advantagous.

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Acknowledgements

The following investigators are acknowledged for their contribution to this study: Francesco Frassoni, Genova, Italy; Dragana Stamatovic, Belgrade, Serbia; Ladislav Jebavy, Hradec Kralove, Czech Republic; Bozena Marianska, Warsaw, Poland; Hele Everaus, Tartu, Estonia; Kazimierz Kuliczkowski, Wroclaw, Poland; Andrea Moicean, Bucharest, Romania; Aleksander B. Skotnicki, Cracow, Poland; Alicja Chybicka, Wroclaw, Poland; Jacek Wachowiak, Poznan, Poland; Jerzy Kowalczyk, Anna Dmoszynska, Lublin, Poland; Jolanta Gozdzik, Cracow, Poland; Petr Sedlacek, Prague, Czech Republic; Dusan Pejin, Novi Sad, Serbia; Jelena Rascon, Vilnius, Lithuania; and Miroslaw Markiewicz, Katowice, Poland.

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Authors and Affiliations

  1. Department of Clinical Oncology, Comprehensive Cancer Center, Maria Sklodowska-Curie Memorial Institute Branch Gliwice, Wybrzeze Armii Krajowej 15, 44-101, Gliwice, Poland

    Sebastian Giebel & Jerzy Holowiecki

  2. European Group for Blood and Marrow Transplantation, Acute Leukemia Working Party, Hopital Saint-Antoine, Assistance Publique des Hôpitaux de Paris and Université de Paris 6, Pierre et Marie Curie, Paris, France

    Myriam Labopin

  3. Department of Hematology, University Hospital Center Rebro, Zagreb, Croatia

    Boris Labar

  4. Department of Hematology, University of Medical Sciences, Poznan, Poland

    Mieczyslaw Komarnicki

  5. Department of Hematology and Oncology, Charles University Hospital Pilsen, Pilsen, Czech Republic

    Vladimir Koza

  6. Department of Bone Marrow Transplantation, Szent László Hospital, Budapest, Hungary

    Tamas Masszi

  7. Clinic of Hematology and Transfusion Medicine, University of Brastislava, Bratislava, Slovakia

    Martin Mistrik

  8. Lower Silesian Center for Cellular Transplantation with National Bone Marrow Donor Registry, Wroclaw, Poland

    Andrzej Lange

  9. Department of Hematology, Medical University of Gdansk, Gdansk, Poland

    Andrzej Hellmann

  10. Institute of Hematology and Blood Transfusion, Prague, Czech Republic

    Antonin Vitek

  11. Department of Hematology, University Medical Center Ljubljana, Ljubljana, Slovenia

    Joze Pretnar

  12. Department of Internal Medicine, Hemato-Oncology, University Hospital Brno, Brno, Czech Republic

    Jiri Mayer

  13. Bone Marrow Transplantation Unit, Military Medical Academy, Warsaw, Poland

    Piotr Rzepecki

  14. Department of Hemato-Oncology, University Hospital Olomouc, Olomouc, Czech Republic

    Karel Indrak

  15. Department of Hematology and Oncology, Medical University of Warsaw, Warsaw, Poland

    Wieslaw Wiktor-Jedrzejczak

  16. Department of Hematology and Bone Marrow Transplantation, Silesian Medical University, Katowice, Poland

    Jerzy Wojnar, Malgorzata Krawczyk-Kulis & Slawomira Kyrcz-Krzemien

  17. Department of Hematology, Hopital Saint-Louis, Assistance Publique Hopitaux de Paris, Paris, France

    Vanderson Rocha

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  1. Sebastian Giebel
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  18. Malgorzata Krawczyk-Kulis
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  19. Slawomira Kyrcz-Krzemien
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  20. Vanderson Rocha
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Correspondence to Sebastian Giebel.

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On behalf of the Acute Leukemia Working Party of the European Group for Blood and Marrow Transplantation

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Giebel, S., Labopin, M., Holowiecki, J. et al. Outcome of HLA-matched related allogeneic hematopoietic stem cell transplantation for patients with acute leukemia in first complete remission treated in Eastern European centers. Better results in recent years. Ann Hematol 88, 1005–1013 (2009). https://doi.org/10.1007/s00277-009-0719-5

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