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Local Control and Analgesic Efficacy of Percutaneous Cryoablation for Desmoid Tumors

  • Clinical Investigation
  • Non-Vascular Interventions
  • Published:
CardioVascular and Interventional Radiology Aims and scope Submit manuscript

Abstract

Objective

Cryoablation is being more and more often used to treat desmoid tumors. We report our experience of cryoablation as a local and analgesic treatment for inoperable or recurring desmoid tumors.

Methods

This study includes 34 patients who underwent percutaneous cryoablation of 41 desmoid tumors between July 2012 and September 2016. All patients underwent pain assessment using a visual analog scale (VAS) and preoperative imaging. All cryoablation procedures were performed using the same cryoablation system. Patients received clinical and radiological follow-up at 6 months post-procedure, with pain-rating and adverse events being recorded. A long-term follow-up was achieved until 31 December 2018. Disease-free survival at 3 years was also recorded. Radiological tumor response was determined by tumor measurements using RECIST 1.1.

Results

Twelve patients benefitted from curative treatment on 100% of the tumor volume, but 22 patients received debulking treatment because of the risk of neighboring structures. Two patients had a postoperative hematoma grade 2 of the CIRSE classification system for complications, and two patients had grade 4 complications involving palsy of the common fibular nerve. Disease-free survival at 3 years was 42.2%. The mean VAS pain scores were 5.7 and 2.4 at pretreatment and 6 months, respectively, showing a mean reduction of 3.3 (p < 0.001). At 6 months, all measured tumor dimensions were significantly lower than pretreatment.

Conclusion

Cryoablation is an effective therapeutic option for the local treatment and for the analgesic management of desmoid tumors.

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Abbreviations

MRI:

Magnetic resonance imaging

CT:

Computed tomography

VAS:

Visual analog scale

ECOG:

Eastern cooperative oncology group

RECIST:

Response evaluation criteria in solid tumors

PD:

Progressive disease

SD:

Stable disease

PR:

Partial response

CR:

Complete response

DFS:

Disease-free survival

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Funding

This study was not supported by any funding.

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Authors and Affiliations

  1. Department of Interventional Radiology, Centre Léon Bérard, 28 Prom. Léa Et Napoléon Bullukian, 69008, Lyon, France

    Amine Bouhamama, Fabrice Lame, Charles Mastier, Marie Cuinet, Antoine Thibaut, Hédi Beji, Alexis Ricoeur, Jean-Yves Blay & Frank Pilleul

  2. Departement of Oncology, Centre Léon Bérard, 28 Prom. Léa Et Napoléon Bullukian, 69008, Lyon, France

    Amine Bouhamama, Fabrice Lame, Charles Mastier, Marie Cuinet, Antoine Thibaut, Alexis Ricoeur, Jean-Yves Blay & Frank Pilleul

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  1. Amine Bouhamama
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Correspondence to Amine Bouhamama.

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Bouhamama, A., Lame, F., Mastier, C. et al. Local Control and Analgesic Efficacy of Percutaneous Cryoablation for Desmoid Tumors. Cardiovasc Intervent Radiol 43, 110–119 (2020). https://doi.org/10.1007/s00270-019-02323-5

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