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Effects of Blood Flow and/or Ventilation Restriction on Radiofrequency Coagulation Size in the Lung: An Experimental Study in Swine

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Abstract

The purpose of this study was to investigate how the restriction of blood flow and/or ventilation affects the radiofrequency (RF) ablation coagulation size in lung parenchyma. Thirty-one RF ablations were done in 16 normal lungs of 8 living swine with 2-cm LeVeen needles. Eight RF ablations were performed as a control (group G1), eight with balloon occlusion of the ipsilateral mainstem bronchus (G2), eight with occlusion of the ipsilateral pulmonary artery (G3), and seven with occlusion of both the ipsilateral bronchus and pulmonary artery (G4). Coagulation diameters and volumes of each ablation zone were compared on computed tomography (CT) and gross specimen examinations. Twenty-six coagulation zones were suitable for evaluation: eight in G1, five in G2, seven in G3, and six in G4 groups. In G1, the mean coagulation diameter was 21.5 ± 3.5 mm on CT and 19.5 ± 1.78 mm on gross specimen examination. In G2, the mean diameters were 26.5 ± 5.1 mm and 23.0 ± 2.7 mm on CT and gross specimen examination, respectively. In G3, the mean diameters were 29.4 ± 2.2 mm and 27.4 ± 2.9 mm on CT and gross specimen examination, respectively, and in G4, they were 32.6 ± 3.33 mm and 28.8 ± 2.6 mm, respectively. The mean coagulation volumes were 3.39 ± l.52 cm3 on CT and 3.01 ± 0.94 cm3 on gross examinations in G1, 6.56 ± 2.47 cm3 and 5.22 ± 0.85 cm3 in G2, 10.93 ± 2.17 cm3 and 9.97 ± 2.91 cm3 in G3, and 13.81 ± 3.03 cm3 and 11.06 ± 3.27 cm3 in G4, respectively. The mean coagulation diameters on gross examination and mean coagulation volumes on CT and gross examination with G3 and G4 were significantly larger than those in G1 (p < 0.0001, p < 0.0001, p < 0.0001, respectively) or in G2 (p < 0.05, p < 0.005, p < 0.005, respectively). Pulmonary collapse occurred in one lung in G2 and pulmonary artery thrombus in two lungs of G3 and two lungs of G4. The coagulation size of RF ablation of the lung parenchyma is increased by ventilation and particularly by pulmonary artery blood flow restriction. The value of these restrictions for potential clinical use needs to be explored in experimentally induced lung tumors.

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References

  1. Goldberg SN, Gazelle GS, Compton CC, et al. (1995) Radio-frequency tissue ablation in the rabbit lung: Efficacy and complications. Acad Radiol 2:776–784

    Article  CAS  PubMed  Google Scholar 

  2. Goldberg SN, Gazelle GS, Compton CC, et al. (1996) Radio-frequency tissue ablation of VX2 tumor nodules in the rabbit lung. Acad Radiol 3:929–935

    Article  CAS  PubMed  Google Scholar 

  3. Dupuy DE, Zagoria RJ, Akerley W, et al. (2000) Percutaneous radiofrequency ablation of malignancies in the lung. Am J Roentgenol 174:57–59

    Article  CAS  PubMed  Google Scholar 

  4. Radiofrequency ablation lung. Available from http://www.ncbi.nlm.nih.gov/entrez Accessed November 5, 2005

  5. Steinke K, Sewell PE, Dupuy D, et al. (2004) Pulmonary radiofrequency ablation: An international study survey. Anticancer Res 24:339–343

    PubMed  Google Scholar 

  6. Herrera LJ, Fernando HC, Perry Y, et al. (2003) Radiofrequency ablation of pulmonary malignant tumors in nonsurgical candidates. J Thorac Cardiovas Surg 125:929–937

    Article  PubMed  Google Scholar 

  7. Gadaleta C, Mattioli V, Colucci G, et al. (2004) Radiofrequency ablation of 40 lung neoplasms: Preliminary results. AJR Am J Roentgenol 183:361–368

    Article  PubMed  Google Scholar 

  8. Yasui K, Kanazawa S, Sano S, et al. (2004) Thoracic tumors treated with CT-guided radiofrequency ablation: Initial experience. Radiology 231:850–857

    Article  PubMed  Google Scholar 

  9. Akeboshi M, Yamakado K, Nakatsuka A, et al. (2004) Percutaneous radiofrequency ablation of lung neoplasms: Initial therapeutic response. J Vasc Intervent Radiol 15:463–470

    Article  Google Scholar 

  10. Lee JM, Jin GY, Goldberg SN, et al. (2004) Percutaneous radiofrequency ablation for inoperable non-small cell lung cancer and metastases. Preliminary report. Radiology 230:125–134

    Article  PubMed  Google Scholar 

  11. Steinke K, Glenn D, King J, et al. (2003) Percutaneous pulmonary radiofrequency ablation: Difficulty achieving complete ablations in big lung lesions. Br J Radiol 76:742–745

    Article  CAS  PubMed  Google Scholar 

  12. Hofftuann RT, Jacobs TF, Reiser MF, et al. (2004) Radiofrequenzablation von Lungentumoren und– metastasen. Radiologe 44:364–369

    Article  Google Scholar 

  13. Miao Y, Ni Y, Bosnians H, et al. (2001) Radiofrequency ablation for eradication of pulmonary tumor in rabbits. J Surg Res 99:265–271

    Article  CAS  PubMed  Google Scholar 

  14. Lee JM, Yong GY, Chuan AL, et al. (2003) Percutaneous radiofrequency thermal ablation of lung VX2 tumors in a rabbit model using a cooled tip electrode: Feasibility, safety and effectiveness. Invest Radiol 38:129–139

    Article  PubMed  Google Scholar 

  15. Goldberg SN, Hahn PF, Tanabe KK, et al. (1998) Percutaneous radiofrequency tissue ablation: Does perfusion mediated tissue cooling limit coagulation necrosis? J Vasc Intervent Radiol 9:101–111

    Article  CAS  Google Scholar 

  16. Goldberg SN, Hahn PF, Halpern EF, et al. (1998) Radio-frequency tissue ablation: Effect of pharmacologic modulation on blood flow on coagulation diameter. Radiology 209:761–767

    Article  CAS  PubMed  Google Scholar 

  17. Patterson EJ, Scudamore CH, Owen DA, et al. (1998) Radiofrequency ablation of porcine liver in vivo: Effects of blood flow and treatment time on lesion size. Ann Surg 227:559–565

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. Washburn WK, Dodd G, Kohlmeier R, et al. (2003) Radiofrequency tissue ablation: Effect of hepatic blood flow occlusion on thermal injuries produced in cirrhotic livers. Ann Surg Oncol 10:773–777

    Article  PubMed  Google Scholar 

  19. Oshima F, Yamakado K, Akeboshi M, et al. (2004) Lung radiofrequency ablation with and without bronchial occlusion: Experimental study in porcine lungs. J Vasc Intervent Radiol 15:1451–1456

    Article  Google Scholar 

  20. Markarian DE (1993) Preparation of inflated lung specimens. In: Groskin SA (ed) Heitzman’s the Lung: Radiologic–Pathologic Correlations, 3rd ed. Mosby, St. Louis, MO, pp 4–12

    Google Scholar 

  21. Goldberg SN, Dupry D (2001) Image-guided radiofrequency tumor ablation: Challenges and opportunities—Part I. J Vasc Intervent Radiol 12:1021–1032

    Article  Google Scholar 

  22. Goldberg SN, Gazelle GS, Dawson SL, et al. (1995) Tissue ablation with radiofrequency: Effect of probe size, gauge, duration and temperature on lesion volume. Acad Radiol 2:399–404

    Article  CAS  PubMed  Google Scholar 

  23. Goldberg SN, Gazelle GS, Dawson SL, et al. (1995) Tissue ablation with radiofrequency using multiprobe arrays. Acad Radiol 2:670–674

    Article  CAS  PubMed  Google Scholar 

  24. LeVeen RF (1997) Laser hyperthermia and radiofrequency ablation of hepatic lesions. Semin Intervent Radiol 14:313–324

    Google Scholar 

  25. Goldberg SN, Gazelle GS, Solbiati L, et al. (1996) Radiofrequency tissue ablation: Increased lesion diameter with a perfusion electrode. Acad Radiol 3:636–644

    Article  CAS  PubMed  Google Scholar 

  26. Pereira PL, Trübenbach J, Schenk M, et al. (2004) Radiofrequency ablation: in vivo comparison of four commercially available devices in pig livers. Radiology 232:482–490

    Article  PubMed  Google Scholar 

  27. Miao Y, Ni Y, Yu J, et al. (2001) An ex vivo study on radiofrequency tissue ablation: Increased lesion size by using an “expandable-wet” electrode. Eur Radiol 11:1841–1847

    Article  CAS  PubMed  Google Scholar 

  28. Gananadha S, Morris DL (2004) Saline infusion markedly reduces impedance and improves efficacy of pulmonary radiofrequency ablation. Cardiovasc Intervent Radiol 27:361–365

    Article  PubMed  Google Scholar 

  29. Goldberg SN (2001) Radiofrequency tumor ablation: Principles and techniques. Eur J Ultrasound 13:129–147

    Article  CAS  PubMed  Google Scholar 

  30. Ahmed M, Liu Z, Afral KS, et al. (2004) Radiofrequency ablation: Effect of surrounding tissue composition on coagulation necrosis in a canine tumor model. Radiology 230:761–767

    Article  PubMed  Google Scholar 

  31. Wacker FK, Nour SG, Eisenberg R, et al. (2004) MRI-guided radiofrequency thermal ablation of normal lung tissue: In vivo study in a rabbit model. AJR Am J Roentgenol 183:599–603

    Article  PubMed  Google Scholar 

  32. Lee JM, Kim SW, Li CA, et al. (2002) Saline-enhance radiofrequency thermal ablation of the lung: A feasibility study in rabbits. Korean J Radiol 4:245–253

    Article  Google Scholar 

  33. Lee JM, Youk JH, Kim YK, et al. (2003) Radiofrequency thermal ablation with hypertonic saline solution injection of the lung: Ex vivo and in vivo feasibility studies. Eur Radiol 13:2540–2547

    Article  PubMed  Google Scholar 

  34. Isawa T, Benfield JR, Johnson DE, et al. (1971) Pulmonary perfusion changes after experimental unilateral bronchial occlusion and their clinical implications. Radiology 99:355–360

    Article  CAS  PubMed  Google Scholar 

  35. Johansen B, Melsom NN, Flatebo T, et al. (1998) Time course and pattern of pulmonary flow distribution following unilateral airway occlusion in sheep. Clin Sci 94:453–460

    Article  CAS  PubMed  Google Scholar 

  36. Severinghaus JW, Swenson EW, Finley TN, et al. (1961) Unilateral hypoventilation produced in dogs by occluding one pulmonary artery. J Appl Physiol 16:53–60

    CAS  PubMed  Google Scholar 

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Correspondence to Dusan Pavcnik.

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Anai, H., Uchida, B.T., Pavcnik, D. et al. Effects of Blood Flow and/or Ventilation Restriction on Radiofrequency Coagulation Size in the Lung: An Experimental Study in Swine. Cardiovasc Intervent Radiol 29, 838–845 (2006). https://doi.org/10.1007/s00270-005-0217-7

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