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Heparin-Coated Angiographic Catheters: An In Vivo Comparison of Three Coating Methods with Different Heparin Release Profiles

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Abstract

We evaluated in vivo anti-thrombogenic effects of three different heparin-coated angiographic catheters with different heparin release profiles. Three different types of heparin-coated 5 French angiographic catheters (rapidly-heparin-releasing, slowly-heparin-releasing, and heparin-adherent catheters) were prepared by coating amphiphilic or hydrophobic heparin derivatives in order to regulate heparin elution. After incubation time of 30 minutes in the arteries of dogs, the amount of thrombus deposition, measured as dry weight, was compared in 10 sets of the three heparin-coated catheters and a non-coated catheter used as control. The surface morphology of catheters after their withdrawal was studied by scanning electron microscopy. The amount of thrombus deposition on the non-coated catheter (374.6 ± 11.6 mg, mean ± SD) was significantly larger than those on the rapidly-heparin-releasing (52.0 ± 12.6), slowly-heparin-releasing (70.4 ± 23.1), and heparin-adherent catheters (103.7 ± 39.9) (p < 0.001, each). The thrombus weights in the three heparin-coated catheters were not statistically different. The scanning electron microscopy showed crusts on the catheter surface, which were thickest in the non-coated catheters. We concluded that the thrombus formation inside a catheter is significantly decreased if the catheter is treated with any of the three heparin-coating methods used in this study. The in vivo anti-thrombogenic effects of these coating methods are not significantly different despite their different heparin release profiles.

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Authors and Affiliations

  1. Department of Radiology, Seoul National University Bundang Hospital, 300 Gumi-dong, Bundang-gu, Seongnam-si, Gyeonggi-do, 463-707, Korea. Seoul National College of Medicine. Institute of Radiation Medicine. Seoul National University Medical Research Center, Korea

    Kyoung Ho Lee, Joon Koo Han & Chang Jin Yoon

  2. Department of Radiology, Seoul National University College of Medicine, 28 Yongon-dong, Chongno-gu, Seoul, 110-744, Korea. Institute of Radiation Medicine, Seoul National University College of Medicine, Clinical Research Institute, Seoul National University Hospital , Korea

    Seung Ja Kim & Byung Ihn Choi

  3. Department of Materials Science and Engineering, Kwangju Institute of Science and Technology, 1 Oryong-dong Puk-gu, Gwangju, 500-712, Korea

    Youngro Byun

  4. Research and Development Division, Mediplex Co., Commercialization Blg, TechnoPark, 958-3 Daechon-dong, Buk-gu, Gwangju, 500-470, Korea

    Hyun Tae Moon

Authors
  1. Kyoung Ho Lee
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  2. Joon Koo Han
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  3. Youngro Byun
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  4. Hyun Tae Moon
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  5. Chang Jin Yoon
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  6. Seung Ja Kim
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  7. Byung Ihn Choi
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Corresponding author

Correspondence to Joon Koo Han.

Additional information

This study was supported in part by the Korean Ministry of Health and Welfare (grant HMP-98-G-2-034).

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Lee, K., Han, J., Byun, Y. et al. Heparin-Coated Angiographic Catheters: An In Vivo Comparison of Three Coating Methods with Different Heparin Release Profiles. CVIR 27, 507–511 (2004). https://doi.org/10.1007/s00270-003-4035-5

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