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Effectiveness and Role of Using Hyaluronic Acid Injections for Gluteal Augmentation: A Comprehensive Systematic Review of Techniques and Outcomes

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  • Non-Surgical Aesthetic Review
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Abstract

Introduction

There has been a rapid increase in the number of patients undergoing non-surgical gluteal augmentation in recent years, leading to an increase in the number of articles in the literature regarding the use of hyaluronic acid (HA) for gluteal augmentation. No systematic review has been published on the effectiveness of HA for gluteal augmentation. This study aimed to provide a comprehensive review regarding the effectiveness and role of using HA for gluteal augmentation.

Methods

This review was conducted according to the PRISMA guidelines for reporting systematic reviews and meta-analyses. We conducted a search across MEDLINE, EMBASE, Cochrane, and Google Scholar, using the following search keywords: gluteus, buttocks, gluteoplasty, gluteal augmentation, hyaluronic acid, and filler.

Results

Ten articles published between 2013 and 2022 that included 168 patients. The estimated duration of product effectiveness is 16.16 months. Most studies showed statistically significant improvements in patients’ satisfaction. Mean volume of HA injected for optimal gluteal fat augmentation was 206.71 ml. Of included studies, two reported major complications, five patients experienced bruising and erythema as minor complications, five patients experienced effusion and inflammation at the injection site, three patients experienced gel dislocation, and one patient experienced irregular contours.

Conclusions

Based on our findings, HA is a predictable method for gluteal augmentation. Patients were satisfied with their outcomes. Despite gluteal augmentation with HA having a modest complication rate, it can still involve serious complications such as diffuse alveolar hemorrhage and death. There is a need for further research in a randomized control trial.

Level of Evidence III

This journal requires that authors assign a level of evidence to each article. For a full description of these evidence-based medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.

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References

  1. Kim JE, Sykes JM (2011) Hyaluronic acid fillers: history and overview. Facial Plastic Surg FPS 27(6):523–528. https://doi.org/10.1055/s-0031-1298785

    Article  CAS  PubMed  Google Scholar 

  2. Tezel A, Fredrickson GH (2008) The science of hyaluronic acid dermal fillers. J Cosmet Laser Ther 10(1):35–42. https://doi.org/10.1080/14764170701774901

    Article  PubMed  Google Scholar 

  3. Gold MH (2007) Use of hyaluronic acid fillers for the treatment of the aging face. Clin Interv Aging 2(3):369–376. https://doi.org/10.2147/cia.s1244

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Wongprasert P, Dreiss CA, Murray G (2022) Evaluating hyaluronic acid dermal fillers: a critique of current characterization methods. Dermatol Ther 35(6):e15453. https://doi.org/10.1111/dth.15453

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Abduljabbar MH, Basendwh MA (2016) Complications of hyaluronic acid fillers and their managements. J Dermatol Dermatol Surg 20(2):100–106

    Article  Google Scholar 

  6. Kalmanson OA, Misch ES, Terella A (2022) Hyaluronic acid fillers may be longer-lasting than previously described: a case report of delayed filler-associated facial cellulitis. JPRAS Open 33:37–41. https://doi.org/10.1016/j.jpra.2022.05.011

    Article  PubMed  PubMed Central  Google Scholar 

  7. Mortada H, Seraj H, Barasain O, Bamakhrama B, Alhindi NI, Arab K (2022) Ocular complications post-cosmetic periocular hyaluronic acid injections: a systematic review. Aesthet Plast Surg 46(2):760–773. https://doi.org/10.1007/s00266-021-02730-5

    Article  Google Scholar 

  8. Santorelli A, Cerullo F, Salti G, Avvedimento S (2022) Gluteal augmentation with hyaluronic acid filler: a retrospective analysis using the BODY-Q scale. Aesthet Plast Surg. https://doi.org/10.1007/s00266-022-03166-1.Advanceonlinepublication.10.1007/s00266-022-03166-1

    Article  Google Scholar 

  9. Atiyeh B, Ghieh F, Oneisi A (2023) Safety and efficiency of minimally invasive buttock augmentation: a review. Aesthet Plast Surg 47(1):245–259. https://doi.org/10.1007/s00266-022-03049-5

    Article  Google Scholar 

  10. Oranges CM, Tremp M, di Summa PG, Haug M, Kalbermatten DF, Harder Y, Schaefer DJ (2017) Gluteal augmentation techniques: a comprehensive literature review. Aesthet Surg J 37(5):560–569. https://doi.org/10.1093/asj/sjw240

    Article  PubMed  Google Scholar 

  11. Dai Y, Chen Y, Hu Y, Zhang L (2022) Current knowledge and future perspectives of buttock augmentation: a bibliometric analysis from 1999 to 2021. Aesthet Plast Surg. https://doi.org/10.1007/s00266-022-03140-x.Advanceonlinepublication.10.1007/s00266-022-03140-x

    Article  Google Scholar 

  12. Moher D, Liberati A, Tetzlaff J, Altman DG, PRISMA Group (2009) Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med 6(7):1000097. https://doi.org/10.1371/journal.pmed.1000097

    Article  Google Scholar 

  13. Higgins J, Green S (eds.) (2011) Cochrane Handbook for Systematic Reviews of Interventions, Version 5.1.0. Available at https://training.cochrane.org/handbook. Accessed 1 June 2021

  14. Ouzzani M, Hammady H, Fedorowicz Z, Elmagarmid A (2016) Rayyan—a web and mobile app for systematic reviews. Syst Rev 5(1):1–10

    Article  Google Scholar 

  15. Murad MH, Sultan S, Haffar S, Bazerbachi F (2018) Methodological quality and synthesis of case series and case reports. BMJ Evid Based Med 23(2):60–63. https://doi.org/10.1136/bmjebm-2017-110853

    Article  PubMed  PubMed Central  Google Scholar 

  16. Stang A (2010) Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol 25(9):603–605. https://doi.org/10.1007/s10654-010-9491-z

    Article  PubMed  Google Scholar 

  17. Sullivan D, Chung KC, Eaves FF 3rd, Rohrich RJ (2021) The level of evidence pyramid: indicating levels of evidence in plastic and reconstructive surgery articles. Plast Reconstr Surg 148(5S):68S-71S. https://doi.org/10.1097/01.prs.0000794868.07051.b4

    Article  CAS  PubMed  Google Scholar 

  18. El-Khalawany M, Fawzy S, Saied A, Al Said M, Amer A, Eassa B (2015) Dermal filler complications: a clinicopathologic study with a spectrum of histologic reaction patterns. Ann Diagn Pathol 19(1):10–15. https://doi.org/10.1016/j.anndiagpath.2014.11.004

    Article  PubMed  Google Scholar 

  19. Lourenço LM, de Noronha MGO, Colla LA, Izzo TR, Sigrist R, Braz A (2022) LL body contour technique—a new way of gluteal contouring and augmentation with hyaluronic acid filler. J Cosmet Dermatol 21(5):1967–1972. https://doi.org/10.1111/jocd.14763

    Article  PubMed  Google Scholar 

  20. Che Ani AA, Mohd Akhir S, Chiang Li-Xue W, Shahidan NZ, Abd Hamid A (2021) Diffuse alveolar haemorrhage and myocardial infarction: life-threatening effects from self-injected hyaluronic acid dermal filler. Monaldi Arch Chest Dis. https://doi.org/10.4081/monaldi.2021.1845

    Article  PubMed  Google Scholar 

  21. Uz İ, Yalçınlı S, Efe M (2020) Fat embolism syndrome after gluteal augmentation with hyaluronic acid: a case report. TJTES 26(6):960–962. https://doi.org/10.14744/tjtes.2019.08433

    Article  PubMed  Google Scholar 

  22. De Meyere B, Mir-Mir S, Peñas J, Camenisch CC, Hedén P (2014) Stabilized hyaluronic acid gel for volume restoration and contouring of the buttocks: 24-month efficacy and safety. Aesthet Plast Surg 38(2):404–412. https://doi.org/10.1007/s00266-013-0251-9

    Article  Google Scholar 

  23. Camenisch CC, Tengvar M, Hedén P (2013) Macrolane for volume restoration and contouring of the buttocks: magnetic resonance imaging study on localization and degradation. Plast Reconstr Surg 132(4):522e–529e. https://doi.org/10.1097/PRS.0b013e31829fe47e

    Article  CAS  PubMed  Google Scholar 

  24. Salahia S, Dar TM (2022) Hyaluronic acid: a safe, biodegradable and biocompatible product for buttock augmentation and contouring. Eur J Med Health Sci 4(3):57–61

    Google Scholar 

  25. Claude O, Bosc R, Pigneur F, Lantieri L (2015) Treatment of HIV-infected subjects with buttock lipoatrophy using stabilized hyaluronic acid gel. Plastic and reconstructive surgery. Global open 3(7):e466. https://doi.org/10.1097/GOX.0000000000000423

    Article  Google Scholar 

  26. Glancey L (2022) The impact of the BBL ban in the UK on patients seeking buttock augmentation. Case Rep Rev Open Access 3(1):127

    Google Scholar 

  27. Hedén P, Sellman G, von Wachenfeldt M, Olenius M, Fagrell D (2020) Body shaping and volume restoration: the role of hyaluronic acid. Aesthet Plast Surg 44:1286–1294

    Article  Google Scholar 

  28. Sinno S, Chang J, Brownstone N, Saadeh P, Wall S (2016) Determining the safety and efficacy of gluteal augmentation: a systematic review of outcomes and complications. Plast Reconst Surg 137(4):1151–1156. https://doi.org/10.1097/PRS.0000000000002005

    Article  CAS  PubMed  Google Scholar 

  29. Flores-Lima G, Eppley BL, Dimas JR, Navarro DE (2013) Surgical pocket location for gluteal implants: a systematic review. Aesth Plast Surg 37(2):240–245. https://doi.org/10.1007/s00266-012-0018-8

    Article  Google Scholar 

  30. Condé-Green A, Kotamarti V, Nini K (2016) Fat grafting for gluteal augmentation: a systematic review of the literature and meta-analysis. Plast Reconst Surg 138(3):437e–446e. https://doi.org/10.1097/PRS.0000000000002435

    Article  CAS  PubMed  Google Scholar 

  31. Colwell AS, Borud LJ (2007) Autologous gluteal augmentation after massive weight loss: aesthetic analysis and role of the superior gluteal artery perforator flap. Plast Reconst Surg 119(1):345–356. https://doi.org/10.1097/01.prs.0000244906.48448.5d

    Article  CAS  PubMed  Google Scholar 

  32. Lin M, Dubin D, Khorasani H (2020) Poly-l-lactic acid for minimally invasive gluteal augmentation. Dermatol Surg 46(3):386–394. https://doi.org/10.1097/DSS.0000000000001967

    Article  CAS  PubMed  Google Scholar 

  33. Lee W, Jung Y, Yang E (2021) Gluteal soft-tissue repositioning using polydioxane threads. Dermatol Surg 47(7):e195–e199. https://doi.org/10.1097/DSS.0000000000002975

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgment

This work was supported by the College of Medicine Research Center, Deanship of Scientific Research, King Saud University Medical City, and King Saud University, Riyadh, Saudi Arabia.

Funding

The authors do not have any conflict of funding to declare.

Author information

Authors and Affiliations

  1. Division of Plastic Surgery, Department of Surgery, King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia

    Hatan Mortada

  2. Department of Plastic Surgery and Burn Unit, King Saud Medical City, Riyadh, Saudi Arabia

    Hatan Mortada

  3. Department of Surgery, College of Medicine, King Saud University, Riyadh, Saudi Arabia

    Danah Alkadi

  4. School of Medicine, Newgiza University (NGU), Giza, Egypt

    Hazem Saqr

  5. King Saud bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia

    Faris Sultan

  6. College of Medicine, King Faisal University, Hafouf, Saudi Arabia

    Batool Alturaiki

  7. Department of Plastic Surgery and Burn Unit, Security Forces Hospital, Riyadh, Saudi Arabia

    Saad Alrobaiea

  8. Division of Plastic Surgery, Department of Surgery, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia

    Hattan A. Aljaaly

  9. Division of Plastic Surgery, Department of Surgery, College of Medicine, King Saud University, Riyadh, Saudi Arabia

    Khalid Arab

  10. Department of Surgery, College of Medicine, Imam Mohammad Ibn Saud Islamic University, Riyadh, Saudi Arabia

    Amr Youssef Arkoubi

  11. Department of Plastic and Reconstructive Surgery, University of Pittsburgh, Pittsburgh, USA

    Hazem Saqr

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  1. Hatan Mortada
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Correspondence to Hatan Mortada.

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Mortada, H., Alkadi, D., Saqr, H. et al. Effectiveness and Role of Using Hyaluronic Acid Injections for Gluteal Augmentation: A Comprehensive Systematic Review of Techniques and Outcomes. Aesth Plast Surg 47, 2719–2733 (2023). https://doi.org/10.1007/s00266-023-03458-0

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