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Efficacy and Safety of Tranexamic Acid for the Control of Surgical Bleeding in Patients Under Liposuction

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Abstract

Liposuction remains one of the most frequently performed cosmetic surgical procedures and its popularity is increasing every year. However, since its inception, justified concerns regarding patient safety have placed limits on the volume of fat that can be aspirated, influenced by hemodynamic fluctuations and blood loss during liposuction. Tranexamic acid (TXA) is an antifibrinolytic agent that competitively inhibits the conversion of plasminogen to plasmin, thus preventing the binding and degradation of fibrin. Despite the existence of evidence of the effectiveness of TXA in orthopedic and cardiac surgeries, there is little evidence of its use in liposuction. The objective of this study was to evaluate the efficacy and safety of tranexamic acid in the control of surgical bleeding in patients undergoing liposuction, through a prospective, open, randomized and controlled clinical trial. Two groups of 25 participants each were formed to whom the application of TXA in a tumescent solution prior to liposuction or liposuction with the traditional technique was randomly assigned. The results showed a decrease in blood loss reflected by the differences in the final hematocrit values, as well as decrease in the same per aspirated volume (p = 0.003). No adverse events were found related with the TXA application and no blood transfusions were required in this group, in contrast to the control group where the need for blood transfusion was present in 20% of the intervened participants.

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Authors and Affiliations

  1. Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado, Hospital Regional “Dr. Valentín Gómez Farias”, Av. Soledad Orozco 203, El Capullo, 45100, Zapopan, Guadalajara, Jalisco, México

    F. A. Rodríguez-García, J. L. Villarreal-Salgado, H. J. Álvarez-Trejo, V. M. Medina-Quintana, S. E. García-Valenzuela, K. E. Morfin-Meza, D. A. Fierro-Rodríguez, E. Dorado-Hernández, P. V. Bonilla-Catalán, J. Ramos-Maciel, E. Romero-Algara & K. E. Jiménez-Pavón

  2. Hospital INNOVARE, Av. Verona 7412, Villa Verona, Zapopan, Jalisco, México

    M. A. Sánchez-Peña & G. Talleri de Andrea

  3. Universidad Juárez del Estado de Durango, Calle Paloma No.806, Colonia Fátima, 34060, Durango, Durango, México

    Q. L. Torres-Salazar

Authors
  1. F. A. Rodríguez-García
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  2. M. A. Sánchez-Peña
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  3. G. Talleri de Andrea
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  6. V. M. Medina-Quintana
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  11. P. V. Bonilla-Catalán
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  15. Q. L. Torres-Salazar
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Corresponding author

Correspondence to Q. L. Torres-Salazar.

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The authors declare that they have no conflicts of interest to disclose.

Ethical Approval

This study considers the ethical aspects in the Declaration of Helsinki, as last modified by the 64th General Assembly, Fortaleza, Brazil, October 2013. This study was reviewed and approved by the Research and Ethics Committee of the Regional Hospital of ISSSTE “Dr. Valentín Gómez Farías” with registration number CEI/421/2020.

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Rodríguez-García, F.A., Sánchez-Peña, M.A., de Andrea, G.T. et al. Efficacy and Safety of Tranexamic Acid for the Control of Surgical Bleeding in Patients Under Liposuction. Aesth Plast Surg 46, 258–264 (2022). https://doi.org/10.1007/s00266-021-02486-y

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  • DOI: https://doi.org/10.1007/s00266-021-02486-y

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