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To the Editor,
We would like to thank you for your interest in our research and article and for some questions and comments through the Letter to the Editor. We would like to respond to them.
Firstly, we applied a mixture of EV and hydrogel inside the full thickness skin defect wound and dressed using Tegaderm (3M, St. Paul, MN, USA) it. Additionally, we used male Sprague-Dowley rats (Crl:CD(SD), 16 wks) in our study, and did not measure their weight, but most of them were about the same size.
Secondly, we measured the positive area as image J on the tissue slide and compared the differences between groups by displaying the results on Fig 4, 6, and 8. In addition, we have confirmed the expression of CD31 and VEGF stimulating angiogenesis, which are mainly used for evaluating angiogenesis, and thank you for your recommendation.
Finally, further research will be conducted on how EVs separated from 3D-cultured PVCs have a better effect on wound healing than PVC-2D-EVs.
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All of procedures to animal were performed after obtaining approval from Eulji University Institutional Animal Care and Use Committee (EUIACUC-16-20). All experiments were performed following the approved protocol in accordance with the institutional guidelines.
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Lee, J.H. Invited Response on: Letter to the Editor on “Extracellular Vesicles From a Three-Dimensional Culture of Perivascular Cells Accelerate Skin Wound healing in a Rat”. Aesth Plast Surg 46, 583 (2022). https://doi.org/10.1007/s00266-021-02332-1
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DOI: https://doi.org/10.1007/s00266-021-02332-1