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Liver regeneration after living adult right lobe transplantation

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Abstract

Background: The purpose of this study was to describe liver regeneration in patients undergoing living-adult liver transplantation.

Methods: This prospective study included 10 donors and eight recipients who had a total of 65 computed tomographic (CT) scans. All patients had preoperative CT (n = 18), and follow-up CT scans (n = 47) were obtained for up to 14 months after transplantation. Liver and spleen volumes were measured by hand tracing each organ on the axial portal venous phase images.

Results: Both donors and recipients showed immediate increases in liver volume. However, liver regeneration was significantly faster and reached a higher peak in recipients than in donors. Splenic volume in donors demonstrated an initial increase followed by a decline, reaching the preoperative volume after 1 year. Splenic volume in recipients demonstrated immediate decline postoperatively.

Conclusion: Restoration of liver volume occurred rapidly after transplantation, but followed different patterns in donors and recipients. Deviation from these patterns warrants further investigation.

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Authors and Affiliations

  1. The Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, MD 21287, USA, , , , , , US

    I. R. Kamel

  2. Institute of Liver Transplantation, Lahey Clinic Medical Center, 41 Mall Road, Burlington, MA 01805, USA, , , , , , US

    N. Erbay & E. A. Pomfret

  3. Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA, , , , , , US

    G. Warmbrand, J. B. Kruskal & V. Raptopoulos

Authors
  1. I. R. Kamel
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  2. N. Erbay
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  3. G. Warmbrand
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  4. J. B. Kruskal
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  5. E. A. Pomfret
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  6. V. Raptopoulos
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Additional information

Received: 1 September 2001/Revision accepted: 16 November 2001

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Kamel, I., Erbay, N., Warmbrand, G. et al. Liver regeneration after living adult right lobe transplantation. Abdom Imaging 28, 0053–0057 (2003). https://doi.org/10.1007/s00261-001-0192-7

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  • DOI: https://doi.org/10.1007/s00261-001-0192-7

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