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Can integrated 18F-FDG PET/MR replace sentinel lymph node resection in malignant melanoma?

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European Journal of Nuclear Medicine and Molecular Imaging Aims and scope Submit manuscript

Abstract

Purpose

To compare the sensitivity and specificity of 18F-fluordesoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT), 18F-FDG PET/magnetic resonance (18F-FDG PET/MR) and 18F-FDG PET/MR including diffusion weighted imaging (DWI) in the detection of sentinel lymph node metastases in patients suffering from malignant melanoma.

Material & Methods

Fifty-two patients with malignant melanoma (female: n = 30, male: n = 22, mean age 50.5 ± 16.0 years, mean tumor thickness 2.28 ± 1.97 mm) who underwent 18F-FDG PET/CT and subsequent PET/MR & DWI for distant metastasis staging were included in this retrospective study. After hybrid imaging, lymphoscintigraphy including single photon emission computed tomography/CT (SPECT/CT) was performed to identify the sentinel lymph node prior to sentinel lymph node biopsy (SLNB). In a total of 87 sentinel lymph nodes in 64 lymph node basins visible on SPECT/CT, 17 lymph node metastases were detected by histopathology. In separate sessions PET/CT, PET/MR, and PET/MR & DWI were assessed for sentinel lymph node metastases by two independent readers. Discrepant results were resolved in a consensus reading. Sensitivities, specificities, positive predictive values and negative predictive values were calculated with histopathology following SPECT/CT guided SLNB as a reference standard.

Results

Compared with histopathology, lymph nodes were true positive in three cases, true negative in 65 cases, false positive in three cases and false negative in 14 cases in PET/CT. PET/MR was true positive in four cases, true negative in 63 cases, false positive in two cases and false negative in 13 cases. Hence, we observed a sensitivity, specificity, positive predictive value and negative predictive value of 17.7, 95.6, 50.0 and 82.3% for PET/CT and 23.5, 96.9, 66.7 and 82.3% for PET/MR. In DWI, 56 sentinel lymph node basins could be analyzed. Here, the additional analysis of DWI led to two additional false positive findings, while the number of true positive findings could not be increased.

Conclusion

In conclusion, integrated 18F-FDG PET/MR does not reliably differentiate N-positive from N-negative melanoma patients. Additional DWI does not increase the sensitivity of 18F-FDG PET/MR. Hence, sentinel lymph node biopsy cannot be replaced by 18F-FDG-PE/MR or 18F-FDG-PET/CT.

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Authors and Affiliations

  1. Medical Faculty, Department of Diagnostic and Interventional Radiology, Univ Dusseldorf, Dusseldorf, Germany

    Benedikt Michael Schaarschmidt, Philipp Heusch & Gerald Antoch

  2. Medical Faculty, Department of Diagnostic and Interventional Radiology and Neuroradiology, Univ Duisburg-Essen, Essen, Germany

    Johannes Grueneisen & Lale Umutlu

  3. Medical Faculty, Department of Nuclear Medicine, Univ Duisburg-Essen, Essen, Germany

    Vanessa Stebner & Thorsten Dirk Pöppel

  4. Department of Dermatology, Venerology and Allergology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany

    Joachim Klode, Ingo Stoffels & Dirk Schadendorf

  5. West German Cancer Center, University Duisburg-Essen, 45122, Essen, Germany

    Joachim Klode, Ingo Stoffels & Dirk Schadendorf

  6. German Cancer Consortium (DKTK), 69120, Heidelberg, Germany

    Joachim Klode, Ingo Stoffels & Dirk Schadendorf

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  1. Benedikt Michael Schaarschmidt
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Correspondence to Benedikt Michael Schaarschmidt.

Ethics declarations

Benedikt M. Schaarschmidt is a stockholder for Bayer AG, General Electric, Siemens AG, Siemencs Healthineers AG, TEVA Pharmaceuticals. All other authors declare that they have no conflict of interest. All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. Informed consent was obtained from all individual participants included in the study.

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Schaarschmidt, B.M., Grueneisen, J., Stebner, V. et al. Can integrated 18F-FDG PET/MR replace sentinel lymph node resection in malignant melanoma?. Eur J Nucl Med Mol Imaging 45, 2093–2102 (2018). https://doi.org/10.1007/s00259-018-4061-9

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  • DOI: https://doi.org/10.1007/s00259-018-4061-9

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