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Myxoid liposarcoma originating in the retroperitoneum with metastasis to the calcaneus: a rare case report and review of literature

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Abstract

Myxoid liposarcoma (MLPS) is known to have a variety of metastatic manifestations. We report a MLPS originating in the pelvis with metastasis to the calcaneus. The patient was a 72-year-old man who developed lumbar pain and right lower extremity pain 2 years ago. He visited a nearby clinic and underwent a radiographic examination. Computed tomography (CT) revealed a tumor in the right retroperitoneum. A CT-guided needle biopsy was performed, and pathological examination revealed myxoid liposarcoma. Wide surgical resection was not performed due to the patients’ wishes, technical difficulties, and magnitude of the invasion, and the patient received heavy particle radiation therapy (HPRT) of 70.4 Gy. After HPRT, the tumor mass was slightly reduced. However, 11 months after HPRT, a recurrent lesion in the liver was observed. Although HPRT was performed again for the metastatic liver lesion (70.4 Gy), the tumor increased in size. Furthermore, 1 month later, the patient complained of pain in the left foot, and CT and magnetic resonance imaging revealed an osteolytic lesion in the calcaneus. A biopsy was performed, and pathological examination showed a metastatic lesion of myxoid-type liposarcoma. The patient wore a short lower limb orthosis and was able to walk but died 1 month later. Oncologists should note that MLPS can metastasize to the calcaneus.

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Acknowledgements

We thank Editage for the English editing. We also thank Chikoto Tanaka for technical support with the immunohistochemical staining.

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Authors and Affiliations

  1. Department of Orthopaedic Surgery, Kindai University Hospital, 377-2 Ohno-higashi, Osaka-Sayama City, Osaka, 589-8511, Japan

    Kazuhiko Hashimoto, Shunji Nishimura, Tomohiko Ito & Masao Akagi

  2. Department of Medical Oncology, Faculty of Medicine, Kindai University, 377-2 Ohno-higashi, Osaka-Sayama, Osaka, 589-8511, Japan

    Seiichiro Mitani

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  1. Kazuhiko Hashimoto
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  2. Shunji Nishimura
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Correspondence to Kazuhiko Hashimoto.

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Hashimoto, K., Nishimura, S., Mitani, S. et al. Myxoid liposarcoma originating in the retroperitoneum with metastasis to the calcaneus: a rare case report and review of literature. Skeletal Radiol 51, 2053–2058 (2022). https://doi.org/10.1007/s00256-022-04028-2

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