Abstract
Soft tissue sarcomas (STS) are rare. Affected patients are at increased risk of developing a second primary malignancy, particularly another primary STS. These rarely affect the extremities, tending to occur in the abdomen, head or neck. We describe a patient with myxofibrosarcoma of the buttock who developed a second primary tumour of the same histological type in the contralateral buttock thirty months after excision. Remarkably, the second tumour was symmetrical and there were no predisposing factors or evidence of metastatic spread. The second tumour was a significant size at presentation with encasement of the sciatic nerve. Awareness of the sarcoma patient's increased risk of developing a second tumour could lead to earlier diagnosis and improved outcome. A review of the literature on multiple soft tissue sarcomas is also presented.
References
Cancer Research UK—Cancer incidence, UK statistics (info.cancerresearchuk.org)
Grobmyer S, Luther N, Antonescu C, Singer S, Brennan M. Multiple primary soft tissue sarcomas. Cancer. 2004;101:2633–5.
Fernebro J, Carneiro A, Rydholm A, et al. Genetic profiling differentiates second primary tumors from metastases in adult metachronous soft tissue sarcoma. Sarcoma 2008;2008:431019.
Merimsky O, Kollender Y, Issakov J, et al. Multiple primary malignancies in association with soft tissue sarcomas. Cancer. 2001;91:1363–71.
Daigeler A, Lehnhardt M, Sebastian A, et al. Metachronous bilateral soft tissue sarcoma of the extremities. Langenbecks Arch Surg. 2008;393:207–12.
Aurello P, Cicchini C, De Angelis R, et al. Synchronous and metachronous retroperitoneal sarcomas: two case reports. Anticancer Res. 2002;22:2409–12.
Antonescu CR, Elahi A, Healey JH, et al. Monoclonality of multifocal myxoid liposarcoma: confirmation by analysis of TLS-CHOP or EWS-CHOP rearrangements. Clin Cancer Res. 2000;6:2788–93.
Johnson FE, Sakata K, Sarkar S, et al. Patient surveillance after treatment of soft-tissue sarcoma. Int J Oncol. 2011;38(1):233–9.
Grimer R, Judson I, Peake D, Seddon B. Guidelines for the management of soft tissue sarcomas. Sarcoma. 2010;2010:317462.
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Picardo, N.E., Mann, B., Whittingham-Jones, P. et al. Bilateral symmetrical metachronous myxofibrosarcoma: a case report and review of the literature. Skeletal Radiol 40, 1085–1088 (2011). https://doi.org/10.1007/s00256-011-1123-5
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DOI: https://doi.org/10.1007/s00256-011-1123-5