Abstract
Medicinal plants are a rich source of natural products used to treat many diseases; therefore, they are the basis for a new drug discovery. Plants are capable of generating different bioactive secondary metabolites, but a large amount of botanical material is often necessary to obtain small amounts of the target substance. Nowadays, many medicinal plants are becoming rather scarce. For this reason, it is important to point out the interactions between endophytic microorganisms and the host plant, because endophytes are able to produce highly diverse compounds, including those from host plants that have important biological activities. Thence, this review aims at presenting the richness in bioactive compounds of the medicinal plants from Tabebuia and Handroanthus genera, as well as important aspects about endophyte-plant interactions, with emphasis on the production of bioactive compounds by endophytic fungi, which has been isolated from various medicinal plants for such a purpose. Furthermore, bio-prospection of natural products synthesized by endophytes isolated from the aforementioned genera used in traditional medicine could be used to treat illnesses.
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References
Anesini C, Perez C (1993) Screening of plants used in Argentine folk medicine for antimicrobial activity. J Ethnopharmacol 39:119–128. https://doi.org/10.1016/0378-8741(93)90027-3
Böhler T, Nolting J, Gurragchaa P, Lupescu A, Neumayer HH, Budde K, Kamar N, Klupp J (2008) Tabebuia avellanedae extracts inhibit IL-2-independent T-lymphocyte activation and proliferation. Transpl Immunol 18:319–323. https://doi.org/10.1016/j.trim.2007.08.005
Braga de Oliveira A, Raslan DS, de Oliveira GG, Maia JGS (1993) Lignans and naphthoquinones from Tabebuia incana. Phytochemistry 34:1409–1412. https://doi.org/10.1016/0031-9422(91)80039-4
Brandão GC, Kroon EG, Santos JR, Stehmann JR, Lombardi JA, Oliveira AB (2010) Antiviral activities of plants occurring in the state of Minas Gerais, Brazil. Part 2. Screening Bignoniaceae species. Rev Bras Farmacogn 20(5):742–750. https://doi.org/10.1590/S0102-695X2010005000035
Camehl I, Drzewiecki C, Vadassery J, Shahollari B, Sherameti I, Forzani C, Munnik T, Hirt H, Oelmüller R (2011) The OXI1 kinase pathway mediates Piriformospora indica-induced growth promotion in Arabidopsis. PLoS Pathog 7:e1002051. https://doi.org/10.1371/journal.ppat.1002051
Carvalho PLN, Silva EO, Chagas-Paula DA, Luiz JHH, Ikegaki M (2016) Importance and implications of the production of phenolic secondary metabolities by endophytic fungi: a mini-review. Mini Rev Med Chem 16(4):259–271. https://doi.org/10.2174/1389557515666151016123923
Cassady JM, Chan KK, Floss HG, Leistner E (2004) Recent developments in the maytansinoid antitumor agents. Chem Pharm Bull 52(1):1–26. https://doi.org/10.1248/cpb.52.1
Castellanos JRG, Prieto JM, Heinrich M (2009) Red Lapacho (Tabebuia impetiginosa)—a global ethnopharmacological commodity? J Ethnopharmacol 121:1–13. https://doi.org/10.1016/j.jep.2008.10.004
Chen S-L, Yu H, Luo H-M, Wu Q, Li C-F, Steinmetz A (2016) Conservation and sustainable use of medicinal plants: problems, progress, and prospects. Chin Med 11(1):37. https://doi.org/10.1186/s13020-016-0108-7
Chithra S, Jasim B, Anisha C, Mathew J, Radhakrishnan EK (2014) LC-MS/MS based identification of piperine production by endophytic Mycosphaerella sp. PF13 from Piper nigrum. Appl Biochem Biotechnol 173(1):30–35. https://doi.org/10.1007/s12010-014-0832-3
Choi W, Um M, Ahn J, Jung C, Park M, Ha T (2014) Ethanolic extract of Taheebo attenuates increase in body weight and fatty liver in mice fed a high-fat diet. Molecules 19(10):16013–16023. https://doi.org/10.3390/molecules191016013
Coelho JM, Antoniolli AB, Nunes e Silva D, TMMB C, ERJC P, Odashiro NA (2010) O efeito da sulfadiazina de prata, extrato de ipê-roxo e extrato de barbatimão na cicatrização de feridas cutâneas em ratos. Rev Col Bras Cir 37:45–51. https://doi.org/10.1590/S0100-69912010000100010
Cui Y, Yi D, Bai X, Sun B, Zhao Y, Zhang Y (2012) Ginkgolide B produced endophytic fungus (Fusarium oxysporum) isolated from Ginkgo biloba. Fitoterapia 83(5):913–920. https://doi.org/10.1016/j.fitote.2012.04.009
Cui J, Guo T, Chao J, Wang M, Wang J (2016) Potential of the endophytic fungus Phialocephala fortinii Rac56 found in Rhodiola plants to produce salidroside and p-tyrosol. Molecules 21(4):502. https://doi.org/10.3390/molecules21040502
De Medeiros PM, Ladio AH, De Albuquerque UP (2013) Patterns of medicinal plant use by inhabitants of Brazilian urban and rural areas: a macroscale investigation based on available literature. J Ethnopharmacol 150:729–746. https://doi.org/10.1016/j.jep.2013.09.026
De Melo JG, De Sousa Araújo TA, De Almeida Castro VTN, De Vasconcelos Cabral DL, Do Desterro Rodrigues M, Do Nascimento SC, De Amorim ELC, De Albuquerque UP (2010) Antiproliferative activity, antioxidant capacity and tannin content in plants of semi-arid northeastern Brazil. Molecules 15:8534–8542. https://doi.org/10.3390/molecules15128534
De Melo JG, Santos AG, De Amorim ELC, Do Nascimento SC, De Albuquerque UP (2011) Medicinal plants used as antitumor agents in Brazil: an ethnobotanical approach. Evid Based Complement Alternat Med 2011:1–14. https://doi.org/10.1155/2011/365359
Devari S, Jaglan S, Kumar M, Deshidi R, Guru S, Bhushan S, Kushwaha M, Gupta AP, Gandhi SG, Sharma JP, Taneja SC, Vishwakarma RA, Shah BA (2014) Capsaicin production by Alternaria alternata, an endophytic fungus from Capsicum annum; LC-ESI-MS/MS analysis. Phytochemestry 98:183–189. https://doi.org/10.1016/j.phytochem.2013.12.001
El-Hawary SS, Mohammed R, Abouzid SF, Bakeer W, Ebel R, Sayed AM, Rateb ME (2016) Solamargine production by a fungal endophyte of Solanum nigrum. J Appl Microbiol 120(4):900–911. https://doi.org/10.1111/jam.13077
Ferraz-Filha ZS, Araujo COM, Ferrari FC, Dutra IPAR, Saúde-Guimarães DA (2016) Tabebuia roseoalba: in vivo hypouricemic and anti-inflammatory effects of its ethanolic extract and constituents. Planta Med 82:1395–1402. https://doi.org/10.1055/s-0042-105878
Ferreira Júnior WS, Ladio AH, De Albuquerque UP (2011) Resilience and adaptation in the use of medicinal plants with suspected anti-inflammatory activity in the Brazilian Northeast. J Ethnopharmacol 138:238–252. https://doi.org/10.1016/j.jep.2011.09.018
Ferreira-Júnior JC, Conserva LM, Lemos RPL, Omena-Neta GC, Cavalcante-Neto A, Barreto E (2015) Isolation of a dihydrobenzofuran lignin, icariside E4, with an antinociceptive effect from Tabebuia roseo-alba (Ridley) Sandwith (Bignoniaceae) bark. Arch Pharm Res 38:950–956. https://doi.org/10.1007/s12272-014-0468-4
Freitas AE, Machado DG, Budni J, Neis VB, Balen GO, Lopes MW, De Souza LF, Veronezi PO, Heller M, Micke GA, Pizzolatti MG, Dafre AL, Leal RB, Rodrigues ALS (2013) Antidepressant-like action of the bark ethanolic extract from Tabebuia avellanedae in the olfactory bulbectomized mice. J Ethnopharmacol 145:737–745. https://doi.org/10.1016/j.jep.2012.11.040
Gentry AH (1969) Tabebuia: the tortuous history of a generic name (Bignon.). Taxon 18(6):635–642. https://doi.org/10.2307/1218919
Gentry AH (1992) A synopsis of Bignoniaceae ethnobotany and economic botany. Ann Mo Bot Gard 79:53–64. https://doi.org/10.2307/2399809
Gouda S, Das G, Sen SK, Shin HS, Patra JK (2016) Endophytes: a treasure house of bioactive compounds of medicinal importance. Front Microbiol 7:1–8. https://doi.org/10.3389/fmicb.2016.01538
Govindappa M, Channabasava R, Sunil Kumar KR, Pushpalatha KC (2013) Antioxidant activity and phytochemical screening of crude endophytes extracts of Tabebuia argentea Bur. & K. Sch. Am J Plant Sci 4:1641–1652. https://doi.org/10.4236/ajps.2013.48198
Grose SO, Olmstead RG (2007a) Evolution of a charismatic neotropical clade: molecular phylogeny of Tabebuia s.l., Crescentieae and allied genera (Bignoniaceae). Syst Bot 32(3):650–659. https://doi.org/10.1600/036364407782250553
Grose SO, Olmstead RG (2007b) Evolution of a charismatic neotropical clade: taxonomic revisions in the polyphyletic genus Tabebuia s.l. (Bignoniaceae). Syst Bot 32(3):660–670. https://doi.org/10.1600/036364407782250652
Hardoim PR, van Overbeek LS, Berg G, Pirttilä AM, Compant S, Campisano A, Döring M, Sessitsch A (2015) The hidden world within plants: ecological and evolutionary considerations for defining functioning of microbial endophytes. Microbiol Mol Biol Rev 79(3):293–320. https://doi.org/10.1128/MMBR.00050-14
Hu X, Li W, Yuan M, Li C, Liu S, Jiang C, Wu Y, Cai K, Liu Y (2016) Homoharringtonine production by endophytic fungus isolated from Cephalotaxus hainanensis Li. World J Microbiol Biotechnol 32(7):1–9. https://doi.org/10.1007/s11274-016-2073-9
Jia M, Chen L, Xin HL, Zheng CJ, Rahman K, Han T, Qin LP (2016) A friendly relationship between endophytic fungi and medicinal plants: a systematic review. Front Microbiol 7:1–14. https://doi.org/10.3389/fmicb.2016.00906
Kaul S, Ahmed M, Zargar K, Sharma P, Dhar MK (2013) Prospecting endophytic fungal assemblage of Digitalis lanata Ehrh. (foxglove) as a novel source of digoxin: a cardiac glycoside. 3 Biotech 3(4):335–340. https://doi.org/10.1007/s13205-012-0106-0
Koyama J, Morita I, Tagahara K, Iria KJ (2000) Cyclopentene dialdehydes from Tabebuia impetiginosus. Phytochemistry 53:869–872. https://doi.org/10.1016/S0031-9422(00)00028-5
Kumar A, Patil D, Rajamohanan PR, Ahmad A (2013) Isolation, purification and characterization of vinblastine and vincristine from endophytic fungus Fusarium oxysporum iisolated from Catharanthus roseus. PLoS One 8:e71805. https://doi.org/10.1371/journal.pone.0071805
Kusari S, Hertweck C, Spiteller M (2012) Chemical ecology of endophytic fungi: origins of secondary metabolites. Chem Biol 19(7):792–798. https://doi.org/10.1016/j.chembiol.2012.06.004
Kusari S, Pandey SP, Spiteller M (2013) Untapped mutualistic paradigms linking host plant and endophytic fungal production of similar bioactive secondary metabolites. Phytochemistry 91:81–87. https://doi.org/10.1016/j.phytochem.2012.07.021
Li X, Zhai X, Shu Z, Dong R, Ming Q, Qin L, Zheng C (2016) Phoma glomerata D14: an endophytic fungus from Salvia miltiorrhiza that produces salvianolic acid C. Curr Microbiol 73(1):31–37. https://doi.org/10.1007/s00284-016-1023-y
Ludwig-Müller J (2015) Plants and endophytes: equal partners in secondary metabolite production? Biotechnol Lett 37(7):1325–1334. https://doi.org/10.1007/s10529-015-1814-4
Maehara S, Simanjuntak P, Kitamura C, Ohashi K, Shibuya H (2011) Cinchona alkaloids are also produced by an endophytic filamentous fungus living in Cinchona plant. Chem Pharm Bull 59(8):1073–1074. https://doi.org/10.1248/cpb.59.1073
Maehara S, Simanjuntak P, Maetani Y, Kitamura C, Ohashi K, Shibuya H (2013) Ability of endophytic filamentous fungi associated with Cinchona ledgeriana to produce cinchona alkaloids. J Nat Med 67(2):421–423. https://doi.org/10.1007/s11418-012-0701-8
Mattos J (1970) Handroanthus, um novo gênero para os “ipês” do Brasil. Loefgrenia 50:1–4
Milke L, Aschenbrenner J, Marienhagen J, Kallscheuer N (2018) Production of plant-derived polyphenols in microorganisms: current state and perspectives. Appl Microbiol Biotechnol 102(4):1575–1585. https://doi.org/10.1007/s00253-018-8747-5
Mir RA, Kaushik PS, Chowdery RA, Anuradha M (2015) Elicitation of forskolin in cultures of Rhizactonia bataticola—a phytochemical synthesizing endophytic fungi. Int J Pharm Pharm Sci 7(10):185–189 ISSN: 0975-1491
Moon DO, Choi YH, Kim ND, Park YM, Kim GY (2007) Anti-inflammatory effects of β-lapachone in lipopolysaccharide-stimulated BV2 microglia. Int Immunopharmacol 7:506–514. https://doi.org/10.1016/j.intimp.2006.12.006
Mootz HD, Schwarzer D, Marahiel MA (2002) Ways of assembling complex natural products on modular nonribosomal peptide synthetases. Chembiochem 3(6):490–504. https://doi.org/10.1002/1439-7633(20020603)3:6<490::aid-cbic490>3.0.co;2-n
Na R, Jiajia L, Dongliang Y, Yingzi P, Juan H, Xiong L, Nana Z, Jing Z, Yitian L (2016) Indentification of vincamine indole alkaloids producing endophytic fungi isolated from Nerium indicum, Apocynaceae. Microbiol Res 192:114–121. https://doi.org/10.1016/j.micres.2016.06.008
Navarro L, Dunoyer P, Jay F, Arnold B, Dharmasiri N, Estelle M, Voinnet O, Jones JDG (2006) A plant miRNA contributes to antibacterial resistance by repressing auxin signaling. Science 312:436–439. https://doi.org/10.1126/science.1126088
Newman DJ, Cragg GM (2016) Natural products as sources of new drugs from 1981 to 2014. J Nat Prod 79(3):629–666. https://doi.org/10.1021/acs.jnatprod.5b01055
Nisa H, Kamili AN, Nawchoo IA, Shafi S, Shameem N, Bandh SA (2015) Fungal endophytes as prolific source of phytochemicals and other bioactive natural products: a review. Microb Pathog 82:50–59. https://doi.org/10.1016/j.micpath.2015.04.001
Oloyede GK, Oladosu IA, Shodia AF, Oloyade OO (2010) Cytotoxic effects of Tabebuia rosea oils (leaf and stem bark). Arch Appl Sci Res 2(3):127–130 http://www.scholarsresearchlibrary.com/articles/cytotoxic-effects-of-tabebuia-rosea-oils-leaf-and-stem-bark.pdf. ISSN 0975-508X
Palem PPC, Kuriakose GC, Jayabaskaran C (2016) Correction: an endophytic fungus, Talaromyces radicus, isolated from Catharanthus roseus, produces vincristine and vinblastine, which induce apoptotic cell death. PLoS One 11(4):1–6. https://doi.org/10.1371/journal.pone.0153111
Pan BF, Su X, Hu B, Yang N, Chen Q, Wu W (2015) Fusarium redolens 6WBY3, an endophytic fungus isolated from Fritillaria unibracteata var. wabuensis, produces peimisine and imperialine-3β-d-glucoside. Fitoterapia 103:213–221. https://doi.org/10.1016/j.fitote.2015.04.006
Park BS, Lee KG, Takeoka GR (2004) Comparison of three sample preparation methods on the recovery of volatile from Taheebo (Tabebuia impetiginosa Martius ex DC). Flavour Frag J 19:287–292. https://doi.org/10.1002/ffj.1345
Park BS, Lee HK, Lee SE, Piao XL, Takeoka GR, Wong RY, Ahn YJ, Kim JH (2006) Antibacterial activity of Tabebuia impetiginosa Martius ex DC (Taheebo) against Helicobacter pylori. J Ethnopharmacol 105:255–262. https://doi.org/10.1016/j.jep.2005.11.005
Pires TCSP, Dias MI, Calhelha RC, Carvalho AM, Queiroz MJRP, Barros L, Ferreira ICFR (2015) Bioactive properties of Tabebuia impetiginosa-based phytopreparations and phytoformulations: a comparison between extracts and dietary supplements. Molecules 20:22863–88871. https://doi.org/10.3390/molecules201219885
Poling SM, Wicklow DT, Rogers KD, Gloer JB (2008) Acremonium zeae, a protective endophyte of maize, produces dihydroresorcylide and 7-hydroxydihydroresorcylides. J Agric Food Chem 56:3006–3009. https://doi.org/10.1021/jf073274f
Pu X, Qu X, Chen F, Bao J, Zhang G, Luo Y (2013) Camptothecin-producing endophytic fungus Trichoderma atroviride LY357: isolation, identification, and fermentation conditions optimization for camptothecin production. Appl Microbiol Biotechnol 97(21):9365–9375. https://doi.org/10.1007/s00253-013-5163-8
Queiroz MLS, Valadares MC, Torello CO, Ramos AL, Oliveira AB, Rocha FD, Arruda VA, Accorci WR (2008) Comparative studies of the effects of Tabebuia avellanedae bark extract and β-lapachone on the hematopoietic response of tumour-bearing mice. J Ethnopharmacol 117:228–235. https://doi.org/10.1016/j.jep.2008.01.034
Ranf S, Eschen-Lippold L, Pecher P, Lee J, Scheel D (2011) Interplay between calcium signalling and early signalling elements during defence responses to microbe- or damage-associated molecular patterns. Plant J 68(1):100–113. https://doi.org/10.1111/j.1365-313X.2011.04671.x
Rao MM, Kingston DG (1982) Plant anticancer agents. XII. Isolation and structure elucidation of new cytotoxic quinones from Tabebuia cassinoides. J Nat Prod 45:600–604. https://doi.org/10.1021/np50023a014
Rodriguez RJ, White JF Jr, Arnold AE, Redman RS (2009) Fungal endophytes: diversity and functional roles. New Phytol 182:314–330. https://doi.org/10.1111/j.1469-8137.2009.02773.x
Sadananda T, Nirupama R, Chaithra K, Govindappa M, Chandrappa C, Raghavendra VB (2011) Antimicrobial and antioxidant activities of endophytes from Tabebuia argentea and identification of anticancer agent (lapachol). J Med Plant Res 5:3643–3652 ISSN 1996-0875
Sakhuja R, Vashist M, Bhoon YK, Jain SC (2014) Phytochemical investigation of Tabebuia palmeri. Chem Nat Compd 49(6):1039–1042. https://doi.org/10.1007/s10600-014-0818-y
Santos VS, Macedo FA, Vale JS, Silva DB, Carollo CA (2017) Metabolomics as a tool for understanding the evolution of Tabebuia sensu lato. Metabolomics 13:1–11. https://doi.org/10.1007/s11306-017-1209-8
Schulz B, Boyle C, Draeger S, Römmert A-K, Krohn K (2002) Endophytic fungi: a source of novel biologically active secondary metabolites. Mycol Res 106(9):996–1004. https://doi.org/10.1017/S0953756202006342
Seetharaman P, Gnanasekar S, Chandrasekaran R, Chandrakasan G, Kadarkarai M, Sivaperumal S (2017) Isolation and characterization of anticancer flavone chrysin (5,7-dihydroxy flavone)-producing endophytic fungi from Passiflora incarnata L. leaves. Ann Microbiol 67(4):321–331. https://doi.org/10.1007/s13213-017-1263-5
Sichaem J, Kaennakam S, Siripong P, Tip-pyang S (2012) Tabebuialdehydes A-C, cyclopentene dialdehyde derivatives from the roots of Tabebuia rosea. Fitoterapia 83:1456–1459. https://doi.org/10.1016/j.fitote.2012.08.010
Singh R, Dubey AK (2015) Endophytic actinomycetes as emerging source for therapeutic compounds. Indo Glob J Pharm Sci 5(2):106–116 ISSN 2249-1023
Son DJ, Lim Y, Park Y-H, Chang S-K, Yun Y-P, Hong J-T, Takeoka GR, Lee K-G, Lee S-E, Kim M-R, Kim J-H, Park BS (2006) Inhibitory effects of Tabebuia impetiginosa inner bark extract on platelet aggregation and vascular smooth muscle cell proliferation through suppressions of arachidonic acid liberation and ERK1/2 MAPK activation. J Ethnopharmacol 108:148–151. https://doi.org/10.1016/j.jep.2006.04.016
Souza IM, Bassi GJ, Luiz JHH, Hirata DB (2018) Isolation and screening of extracellular lipase-producing endophytic Fungi from Handroanthus impetiginosus. Asian J Biotechnol Bioresour Technol 4(2):1–10. https://doi.org/10.9734/AJB2T/2018/43014
Steinert J, Rimpler M (1996) High performance liquid chromatographic separation of some naturally occurring naphthoquinones and antthraquinones. J Chromatogr A 723:206–209
Steinert J, Khalaf H, Rimpler M (1995) HPLC separation and determination of naphtol[2,3-b]furan-4,9-diones and related compounds in extracts of Tabebuia avellanedae (Bignoniaceae). J Chromatogr A 693:281–287
Strobel GA (2003) Endophytes as sources of bioactive products. Microbes Infect 5(6):535–544. https://doi.org/10.1016/S1286-4579(03)00073-X
Strobel GA, Stierle A, Hess WM (1993) Taxol formation in yew - Taxus. Plant Sci 92(1):1–12. https://doi.org/10.1016/0168-9452(93)90060-D
Suo M, Isao H, Kato H, Takano F, Ohta T (2012) Anti-inflammatory constituents from Tabebuia avellanedae. Fitoterapia 83:1484–1488. https://doi.org/10.1016/j.fitote.2012.08.014
Takahashi S, Kawakami S, Sugimoto S, Matsunami K, Otsuka H (2015) Lignan glycosides and phenolic compound glycosides from the branches of Tabebuia chrysotricha. Am J Plant Sci 6:676–684. https://doi.org/10.4236/ajps.2015.65073
Teixeira TL, Teixeira SC, Silva CVD, Souza MAD (2014) Potential therapeutic use of herbal extracts in trypanosomiasis. Pathog Glob Health 108(1):30–36. https://doi.org/10.1179/2047773213Y.0000000120
Twardowschy A, Freitas CS, Baggio CH, Mayer B, Dos Santos AC, Pizzolatti MG, Zacarias AA, Dos Santos EP, Otuki MF, Marques MCA (2008) Antiulcerogenic activity of bark extract of Tabebuia avellanedae, Lorentz ex Griseb. J Ethnopharmacol 118:455–459. https://doi.org/10.1016/j.jep.2008.05.013
Venieraki A, Dimou M, Katinakis P (2017) Endophytic fungi residing in medicinal plants have the ability to produce the same or similar pharmacologically active secondary metabolites as their hosts. Hell Plant Protection J 10(2):51–66. https://doi.org/10.1515/hppj-2017-0006
Vennila R, Muthumary J (2011) Taxol from Pestalotiopsis pauciseta VM1, an endophytic fungus of Tabebuia pentaphylla. Biomed Prev Nutr 1:103–108. https://doi.org/10.1016/j.bionut.2010.12.005
Wagner H, Kreher B, Lotter H, Hamburger MO (1989) Structure determination of new isomeric naphto[2,3-b]furan-4,9-diones from Tabebuia avellanedae by the selective-INEPT technique. Helv Chim Acta 72:659–667. https://doi.org/10.1002/hlca.19890720406
Wang XJ, Min XWC, Ge M, Zuo R (2014) An endophytic sanguinarine-producing fungus from Macleaya cordata, Fusarium proliferatum BLH51. Curr Microbiol 68:336–341. https://doi.org/10.1007/s00284-013-0482-7
Warashima T, Nagatani Y, Noro T (2004) Constituents from the bark of Tabebuia impetiginosa. Phytochemistry 65:2003–2011. https://doi.org/10.1016/j.phytochem.2004.06.012
Warashima T, Nagatani Y, Noro T (2005) Further constituents from the bark of Tabebuia impetiginosa. Phytochemistry 66:589–597. https://doi.org/10.1016/j.phytochem.2005.01.005
Warashima T, Nagatani Y, Noro T (2006) Constituents from the bark of Tabebuia impetiginosa. Chem Pharm Bull 54:14–20. https://doi.org/10.1248/cpb.54.14
Xu J, Wagoner G, Douglas JC, Drew PD (2013) β-Lapachone ameliorization of experimental autoimmune encephalomyelitis. J Neuroimmunol 254:46–54. https://doi.org/10.1016/j.jneuroim.2012.09.004
You X, Feng S, Luo S, Cong D, Yu Z, Yang Z, Zhang J (2013) Studies on a rhein-producing endophytic fungus isolated from Rheum palmatum L. Fitoterapia 85(1):161–168. https://doi.org/10.1016/j.fitote.2012.12.010
Zhang Q, Wei X, Wang J (2012) Phillyrin produced by Colletotrichum gloeosporioides, an endophytic fungus isolated from Forsythia suspensa. Fitoterapia 83(8):1500–1505. https://doi.org/10.1016/j.fitote.2012.08.017
Zhang L, Tatsuno T, Hasegawa I, Tadano T, Ohta T (2015) Furanonaphthoquinones from Tabebuia avellanedae induce cell cycle arrest and apoptosis in the human non-small cell lung cancer cell line A549. Phytochem Lett 11:9–17. https://doi.org/10.1016/j.phytol.2014.09.013
Zhang L, Hasegawa I, Ohta T (2017) Iridoid esters from Tabebuia avellanedae and their in vitro anti-inflammatory activities. Planta Med 83:164–171. https://doi.org/10.1055/s-0042-110322
Zhao J, Fu Y, Luo M, Zu Y, Wang W, Zhao C, Gu C (2012) Endophytic fungi from pigeon pea [Cajanus cajan (L.) Millsp.] produce antioxidant cajaninstilbene acid. J Agric Food Chem 60(17):4314–4319. https://doi.org/10.1021/jf205097y
Zhao J, Li C, Wang W, Zhao C, Luo M, Mu F, Fu Y, Zu Y, Yao M (2013) Hypocrea lixii, novel endophytic fungi producing anticancer agent cajanol, isolated from pigeon pea (Cajanus cajan [L.] Millsp.). J Appl Microbiol 115(1):102–113. https://doi.org/10.1111/jam.12195
Zhou X, Zhu H, Liu L, Lin J, Tang K (2010) A review: recent advances and future prospects of taxol-producing endophytic fungi. Appl Microbiol Biotechnol 86(6):1707–1717. https://doi.org/10.1007/s00253-010-2546-y
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Omar C. Gomez thanks to the Program PEC-PG (Programa de Estudantes-Convênio de Pós-Graduação) of the CAPES/CNPq—Brazil.
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Gómez, O.C., Luiz, J.H.H. Endophytic fungi isolated from medicinal plants: future prospects of bioactive natural products from Tabebuia/Handroanthus endophytes. Appl Microbiol Biotechnol 102, 9105–9119 (2018). https://doi.org/10.1007/s00253-018-9344-3
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DOI: https://doi.org/10.1007/s00253-018-9344-3