Abstract
After we prepared exo-polymers (EPS) from Cordyceps sinensis by submerged culture, prophylactic intravenous administration (i.v.) of EPS significantly inhibited metastasis in experimental lung metastasis of colon 26-M3.1 carcinoma. Cytotoxicity against Yac-1 tumor cells of natural killer (NK) cell, which was prepared by i.v. of EPS (100 μg/mouse), significantly augmented 2 days after EPS treatment. When NK cells were depleted by rabbit anti-asialo GM1 serum, even the EPS group totally abolished the inhibitory effect on lung metastasis of colon 26-M3.1 cells. EPS can stimulate innate immune system to inhibit tumor metastasis, and its anti-tumor metastasis is associated with macrophage and NK cell activation.
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Acknowledgment
This study was carried out with the support of “On-Site Cooperative Agriculture Research Project (Project No. 20070401080069)”, RDA, Republic of Korea.
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Yoon, T.J., Yu, KW., Shin, KS. et al. Innate immune stimulation of exo-polymers prepared from Cordyceps sinensis by submerged culture. Appl Microbiol Biotechnol 80, 1087–1093 (2008). https://doi.org/10.1007/s00253-008-1607-y
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DOI: https://doi.org/10.1007/s00253-008-1607-y