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Pulmonary lymphoproliferative disorders in children: a practical review

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Abstract

Pulmonary lymphoproliferative disorders represent an uncommon spectrum of proliferation of lymphoid tissue in the lung parenchyma ranging from benign hyperplasia to malignancy. They tend to occur in certain clinical situations and have typical imaging features that together can be used by the radiologist to suggest these entities as part of the differential diagnosis. We review key clinical, histopathological and computed tomography features of pulmonary lymphoproliferative disorders in children including follicular bronchiolitis, lymphoid interstitial pneumonia, granulomatous-lymphocytic interstitial lung disease, lymphoma and post-transplant lymphoproliferative disorder to familiarize the pediatric radiologist with this group of disorders.

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References

  1. Sirajuddin A, Raparia K, Lewis VA et al (2016) Primary pulmonary lymphoid lesions: radiologic and pathologic findings. Radiographics 36:53–70

    Article  Google Scholar 

  2. Randall TD (2010) Bronchus-associated lymphoid tissue (BALT) structure and function. Adv Immunol 107:187–241

    Article  CAS  Google Scholar 

  3. Kradin RL, Mark EJ (1983) Benign lymphoid disorders of the lung, with a theory regarding their development. Hum Pathol 14:857–867

    Article  CAS  Google Scholar 

  4. Tian X, Yi ES, Ryu JH (2012) Lymphocytic interstitial pneumonia and other benign lymphoid disorders. Semin Respir Crit Care Med 33:450–461

    Article  Google Scholar 

  5. Yousem SA, Colby TV, Carrington CB (1985) Follicular bronchitis/bronchiolitis. Hum Pathol 16:700–706

    Article  CAS  Google Scholar 

  6. Weinman JP, Manning DA, Liptzin DR et al (2017) HRCT findings of childhood follicular bronchiolitis. Pediatr Radiol 47:1759–1765

    Article  Google Scholar 

  7. Prenzel F, Harfst J, Schwerk N et al (2020) Lymphocytic interstitial pneumonia and follicular bronchiolitis in children: a registry-based case series. Pediatr Pulmonol 55:909–917

    Article  Google Scholar 

  8. Guinee DG Jr (2010) Update on nonneoplastic pulmonary lymphoproliferative disorders and related entities. Arch Pathol Lab Med 134:691–701

    Article  Google Scholar 

  9. Howling SJ, Hansell DM, Wells AU et al (1999) Follicular bronchiolitis: thin-section CT and histologic findings. Radiology 212:637–642

    Article  CAS  Google Scholar 

  10. Nicholson AG (2001) Lymphocytic interstitial pneumonia and other lymphoproliferative disorders in the lung. Semin Respir Crit Care Med 22:409–422

    Article  CAS  Google Scholar 

  11. Panchabhai TS, Farver C, Highland KB (2016) Lymphocytic interstitial pneumonia. Clin Chest Med 37:463–474

    Article  Google Scholar 

  12. Koss MN, Hochholzer L, Langloss JM et al (1987) Lymphoid interstitial pneumonia: clinicopathological and immunopathological findings in 18 cases. Pathology 19:178–185

    Article  CAS  Google Scholar 

  13. Banerjee D, Ahmad D (1982) Malignant lymphoma complicating lymphocytic interstitial pneumonia: a monoclonal B-cell neoplasm arising in a polyclonal lymphoproliferative disorder. Hum Pathol 13:780–782

    Article  CAS  Google Scholar 

  14. Swigris JJ, Berry GJ, Raffin TA, Kuschner WG (2002) Lymphoid interstitial pneumonia: a narrative review. Chest 122:2150–2164

    Article  Google Scholar 

  15. Teruya-Feldstein J, Temeck BK, Sloas MM et al (1995) Pulmonary malignant lymphoma of mucosa-associated lymphoid tissue (MALT) arising in a pediatric HIV-positive patient. Am J Surg Pathol 19:357–363

    Article  CAS  Google Scholar 

  16. Johkoh T, Muller NL, Pickford HA et al (1999) Lymphocytic interstitial pneumonia: thin-section CT findings in 22 patients. Radiology 212:567–572

    Article  CAS  Google Scholar 

  17. Ichikawa Y, Kinoshita M, Koga T et al (1994) Lung cyst formation in lymphocytic interstitial pneumonia: CT features. J Comput Assist Tomogr 18:745–748

    Article  CAS  Google Scholar 

  18. Desai SR, Nicholson AG, Stewart S et al (1997) Benign pulmonary lymphocytic infiltration and amyloidosis: computed tomographic and pathologic features in three cases. J Thorac Imaging 12:215–220

    Article  CAS  Google Scholar 

  19. Rao N, Mackinnon AC, Routes JM (2015) Granulomatous and lymphocytic interstitial lung disease: a spectrum of pulmonary histopathologic lesions in common variable immunodeficiency--histologic and immunohistochemical analyses of 16 cases. Hum Pathol 46:1306–1314

    Article  Google Scholar 

  20. Bates CA, Ellison MC, Lynch DA et al (2004) Granulomatous-lymphocytic lung disease shortens survival in common variable immunodeficiency. J Allergy Clin Immunol 114:415–421

    Article  Google Scholar 

  21. Torigian DA, LaRosa DF, Levinson AI et al (2008) Granulomatous-lymphocytic interstitial lung disease associated with common variable immunodeficiency: CT findings. J Thorac Imaging 23:162–169

    Article  Google Scholar 

  22. Wu X, Zhou C, Jin L et al (2019) Primary pulmonary lymphoma in children. Orphanet J Rare Dis 14:35

    Article  CAS  Google Scholar 

  23. William J, Variakojis D, Yeldandi A, Raparia K (2013) Lymphoproliferative neoplasms of the lung: a review. Arch Pathol Lab Med 137:382–391

    Article  CAS  Google Scholar 

  24. Maturen KE, Blane CE, Strouse PJ, Fitzgerald JT (2004) Pulmonary involvement in pediatric lymphoma. Pediatr Radiol 34:120–124

    Article  Google Scholar 

  25. Hare SS, Souza CA, Bain G et al (2012) The radiological spectrum of pulmonary lymphoproliferative disease. Br J Radiol 85:848–864

    Article  CAS  Google Scholar 

  26. Borhani AA, Hosseinzadeh K, Almusa O et al (2009) Imaging of posttransplantation lymphoproliferative disorder after solid organ transplantation. Radiographics 29:981–1000; discussion 1000–1002

  27. Camacho JC, Moreno CC, Harri PA et al (2014) Posttransplantation lymphoproliferative disease: proposed imaging classification. Radiographics 34:2025–2038

    Article  Google Scholar 

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Authors and Affiliations

  1. Department of Radiology, Cincinnati Children’s Hospital Medical Center, 3333 Burnet Ave., Cincinnati, OH, 45229, USA

    Andrew H. Schapiro & Eric J. Crotty

  2. Department of Radiology, University of Cincinnati College of Medicine, Cincinnati, OH, USA

    Andrew H. Schapiro & Eric J. Crotty

  3. Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA

    Kathryn A. Wikenheiser-Brokamp

  4. Division of Pathology & Laboratory Medicine, and the Perinatal Institute Division of Pulmonary Biology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA

    Kathryn A. Wikenheiser-Brokamp

  5. Department of Radiology, University of Missouri-Kansas City School of Medicine, Kansas City, MO, USA

    Joshua D. Wermers

  6. Department of Radiology, Cleveland Clinic Foundation, Cleveland, OH, USA

    Mantosh S. Rattan

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  1. Andrew H. Schapiro
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  2. Kathryn A. Wikenheiser-Brokamp
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  3. Joshua D. Wermers
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  4. Mantosh S. Rattan
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  5. Eric J. Crotty
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Correspondence to Andrew H. Schapiro.

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Schapiro, A.H., Wikenheiser-Brokamp, K.A., Wermers, J.D. et al. Pulmonary lymphoproliferative disorders in children: a practical review. Pediatr Radiol 52, 1224–1233 (2022). https://doi.org/10.1007/s00247-022-05335-5

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  • DOI: https://doi.org/10.1007/s00247-022-05335-5

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