Skip to main content

Advertisement

SpringerLink
Log in

Radiological features of head and neck mammary analogue secretory carcinoma: 11 new cases with a systematic review of 29 cases reported in 28 publications

  • Head-Neck-ENT Radiology
  • Published:
Neuroradiology Aims and scope Submit manuscript

Abstract

Purpose

This retrospective study aimed to investigate the radiological features of head and neck mammary analogue secretory carcinoma (MASC) and systematically review previous publications and 11 new cases.

Methods

We included patients with pathologically proven MASCs with preoperative CT or MRI images, including 11 patients from our hospital and 29 patients from 28 publications extracted after screening 645 abstracts. Two board-certified radiologists reviewed and evaluated all radiological images. The frequency of metastasis during the follow-up period in tumors with well- and ill-defined margins was compared using a Fisher’s exact test.

Results

The median age at diagnosis was 52.5 years (range, 7–78 years; 20 males). Of the 40 patients, those in their 50 s were the most common (10/40, 25.0%), and the main tumor site was the parotid gland (27/40, 42.5%). Characteristic radiological features included high intensity on T1WI in the cystic components and tumors frequently showed “papillary and cystic,” which showed a projection into the cystic components, or “non-papillary and cystic” morphology, which did not show projection of the solid components. Tumor metastasis was found in 10/35 patients (28.6%) during the follow-up period, with a significant difference in frequency between the tumors with well- and ill-defined margin (well-defined (4/26) vs. ill-defined (6/9); P = 0.0074).

Conclusion

MASCs are newly recognized malignant tumors. Characteristic T1WI high intensity on MRI and predominant cystic morphology may reflect its unique histological profile. Ill-defined tumor margin status was related to frequent metastasis. Awareness of these characteristic radiological features can assist radiologists in better detection of this novel entity.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5

Similar content being viewed by others

Data availability

The underlying data can be accessed at reasonable request to the corresponding author.

References

  1. Seethala RR, Stenman G (2017) Update from the 4th Edition of the World Health Organization Classification of Head and Neck Tumours: tumors of the salivary gland. Head Neck Pathol 11:55–67. https://doi.org/10.1007/s12105-017-0795-0

  2. Skálová A, Vanecek T, Sima R et al (2010) Mammary analogue secretory carcinoma of salivary glands, containing the ETV6-NTRK3 fusion gene: a hitherto undescribed salivary gland tumor entity. Am J Surg Pathol 34:599–608. https://doi.org/10.1097/PAS.0b013e3181d9efcc

    Article  PubMed  Google Scholar 

  3. Skálová A, Gnepp DR, Lewis JS Jr et al (2017) Newly described entities in salivary gland pathology. Am J Surg Pathol 41:e33–e47. https://doi.org/10.1097/PAS.0000000000000883

    Article  PubMed  Google Scholar 

  4. Connor A, Perez-Ordoñez B, Shago M et al (2012) Mammary analog secretory carcinoma of salivary gland origin with the ETV6 gene rearrangement by FISH: expanded morphologic and immunohistochemical spectrum of a recently described entity. Am J Surg Pathol 36:27–34

    Article  Google Scholar 

  5. Khalele BA (2017) Systematic review of mammary analog secretory carcinoma of salivary glands at 7 years after description. Head Neck 39:1243–1248. https://doi.org/10.1002/hed.24755

    Article  PubMed  Google Scholar 

  6. Kashiwagi N, Nakatsuka SI, Murakami T et al (2018) MR imaging features of mammary analogue secretory carcinoma and acinic cell carcinoma of the salivary gland: a preliminary report. Dentomaxillofac Radiol 47:20170218. https://doi.org/10.1259/dmfr.20170218

    Article  PubMed  PubMed Central  Google Scholar 

  7. Page MJ, McKenzie JE, Bossuyt PM et al (2021) The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ 372:n71. https://doi.org/10.1136/bmj.n71

    Article  PubMed  PubMed Central  Google Scholar 

  8. Murad MH, Sultan S, Haffar S, Bazerbachi F (2018) Methodological quality and synthesis of case series and case reports. BMJ Evid Based Med 23:60–63. https://doi.org/10.1136/bmjebm-2017-110853

    Article  PubMed  PubMed Central  Google Scholar 

  9. Helmy D, Chang J, Bishop JW et al (2020) MR imaging findings of a rare pediatric parotid tumor: Mammary analogue secretory carcinoma. Radiol Case Rep 15:1460–1463. https://doi.org/10.1016/j.radcr.2020.05.035

    Article  PubMed  PubMed Central  Google Scholar 

  10. Gupta K, Patwa HS, Niehaus AG et al (2019) Mammary analogue secretory carcinoma presenting as a cystic parotid mass. Radiol Case Rep 14:1103–1108. https://doi.org/10.1016/j.radcr.2019.06.019

    Article  PubMed  PubMed Central  Google Scholar 

  11. Tokuzen N, Goda H, Nakashiro K (2019) Locally advanced mammary analogue secretory carcinoma of the parotid gland. Int J Oral Maxillofac Surg 48:865–868. https://doi.org/10.1016/j.ijom.2019.01.027

    Article  CAS  PubMed  Google Scholar 

  12. Sun L, Thorson T, Zhu R et al (2019) A case report of parotid mammary analogue secretory carcinoma and reviews. Int J Surg Case Rep 55:88–91. https://doi.org/10.1016/j.ijscr.2019.01.004

    Article  PubMed  PubMed Central  Google Scholar 

  13. Shigeta R, Orgun D, Mizuno H, Hayashi A (2018) Mammary analogue secretory carcinoma arising in the parotid gland of child. Plast Reconstr Surg Glob Open 6:e2059. https://doi.org/10.1097/GOX.0000000000002059

    Article  PubMed  PubMed Central  Google Scholar 

  14. Desai MA, Mehrad M, Ely KA et al (2019) Secretory carcinoma of the thyroid gland: report of a highly aggressive case clinically mimicking undifferentiated carcinoma and review of the literature. Head Neck Pathol 13:562–572. https://doi.org/10.1007/s12105-018-0995-2

    Article  PubMed  Google Scholar 

  15. Mossinelli C, Pigni C, Sovardi F et al (2019) Synchronous parotid (mammary analog) secretory carcinoma and acinic cell carcinoma: report of a case. Head Neck Pathol 13:686–691. https://doi.org/10.1007/s12105-018-0935-1

    Article  CAS  PubMed  Google Scholar 

  16. Baneckova M, Agaimy A, Andreasen S et al (2018) Mammary analog secretory carcinoma of the nasal cavity: characterization of 2 cases and their distinction from other low-grade sinonasal denocarcinomas. Am J Surg Pathol 42:735–743. https://doi.org/10.1097/PAS.0000000000001048

    Article  PubMed  Google Scholar 

  17. Cipriani NA, Blair EA, Finkle J et al (2017) Salivary gland secretory carcinoma with high-grade transformation, CDKN2A/B loss, distant metastasis, and lack of sustained response to crizotinib. Int J Surg Pathol 25:613–618. https://doi.org/10.1177/1066896917709350

    Article  PubMed  Google Scholar 

  18. Jin S, Ma H, He Y (2016) Preservation of facial nerve with adjuvant radiotherapy for recurrent mammary analogue secretory carcinoma of parotid gland. J Craniofac Surg 27:e364–e366. https://doi.org/10.1097/SCS.0000000000002622

    Article  PubMed  Google Scholar 

  19. Reynolds S, Shaheen M, Olson G et al (2016) A case of primary mammary analog secretory carcinoma (MASC) of the thyroid masquerading as papillary thyroid carcinoma: potentially more than a one off. Head Neck Pathol 10:405–413. https://doi.org/10.1007/s12105-016-0715-8

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  20. Levine P, Fried K, Krevitt LD et al (2014) Aspiration biopsy of mammary analogue secretory carcinoma of accessory parotid gland: another diagnostic dilemma in matrix-containing tumors of the salivary glands. Diagn Cytopathol 42:49–53. https://doi.org/10.1002/dc.22886

    Article  PubMed  Google Scholar 

  21. Rastatter JC, Jatana KR, Jennings LJ, Melin-Aldana H (2012) Mammary analogue secretory carcinoma of the parotid gland in a pediatric patient. Otolaryngol Head Neck Surg 146:514–515. https://doi.org/10.1177/0194599811419044

    Article  PubMed  Google Scholar 

  22. Min F-H, Li J, Tao B-Q, et al (2021) Parotid mammary analogue secretory carcinoma: a case report and review of literature. World J Clin Cases 9:4052–4062. https://doi.org/10.12998/wjcc.v9.i16.4052

  23. Morimoto M, Sato T, Takano M et al (2021) Secretory carcinoma under the buccal mucosa suspected of being a benign tumor. Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology 33:188–192. https://doi.org/10.1016/j.ajoms.2020.10.008

    Article  Google Scholar 

  24. Numano Y, Ogawa T, Ishikawa T et al (2020) Parotid secretory carcinoma with high-grade transformation. Auris Nasus Larynx 47:1043–1048. https://doi.org/10.1016/j.anl.2019.10.003

    Article  PubMed  Google Scholar 

  25. Boliere C, Murphy J, Qaisi M et al (2019) Mammary analogue secretory carcinoma of the palate: case report and review of the literature. Case Rep Dent 2019:7416302. https://doi.org/10.1155/2019/7416302

    Article  PubMed  PubMed Central  Google Scholar 

  26. Takeda M, Kasai T, Morita K et al (2015) Cytopathological features of mammary analogue secretory carcinoma–review of literature. Diagn Cytopathol 43:131–137. https://doi.org/10.1002/dc.23146

    Article  PubMed  Google Scholar 

  27. Luo W, Lindley SW, Lindley PH et al (2014) Mammary analog secretory carcinoma of salivary gland with high-grade histology arising in hard palate, report of a case and review of literature. Int J Clin Exp Pathol 7:9008–9022

    PubMed  PubMed Central  Google Scholar 

  28. Sethi R, Kozin E, Remenschneider A et al (2014) Mammary analogue secretory carcinoma: update on a new diagnosis of salivary gland malignancy. Laryngoscope 124:188–195. https://doi.org/10.1002/lary.24254

    Article  PubMed  Google Scholar 

  29. Kaleem A, Patel N, Alzahrani S et al (2020) Concurrent presence of secretory carcinoma and Warthin’s tumor in ipsilateral parotid gland. Oral Oncol 109:104691. https://doi.org/10.1016/j.oraloncology.2020.104691

    Article  CAS  PubMed  Google Scholar 

  30. Gonzalez MF, Akhtar I, Manucha V (2018) Additional diagnostic features of mammary analogue secretory carcinoma on cytology. Cytopathology 29:100–103. https://doi.org/10.1111/cyt.12465

    Article  CAS  PubMed  Google Scholar 

  31. Balanzá R, Arrangoiz R, Cordera F et al (2015) Mammary analog secretory carcinoma of the parotid gland: A case report and literature review. Int J Surg Case Rep 16:187–191. https://doi.org/10.1016/j.ijscr.2015.09.031

    Article  PubMed  PubMed Central  Google Scholar 

  32. Hyrcza MD, Andreasen S, Melchior LC et al (2018) Primary secretory carcinoma of the lacrimal gland: report of a new entity. Am J Ophthalmol 193:178–183. https://doi.org/10.1016/j.ajo.2018.06.019

    Article  PubMed  Google Scholar 

  33. Shibata E, Morita K-I, Kayamori K et al (2020) Secretory carcinoma around Stensen’s duct misdiagnosed as salivary duct cyst. Int J Clin Exp Pathol 13:2211–2217

    PubMed  PubMed Central  Google Scholar 

  34. Bill R, Deschler DG, Pittet MJ, et al (2021) Diagnostic challenges and successful organ-preserving therapy in a case of secretory carcinoma of minor salivary glands. Cancer Rep e1491. https://doi.org/10.1002/cnr2.1491

  35. Carlson ER, Schlieve T (2019) Salivary Gland Malignancies. Oral Maxillofac Surg Clin North Am 31:125–144. https://doi.org/10.1016/j.coms.2018.08.007

    Article  PubMed  Google Scholar 

  36. Hamamoto Y, Harada H, Kohara M et al (2021) Usefulness of immunohistochemistry to distinguish between secretory carcinoma and acinic cell carcinoma in the salivary gland. Med Mol Morphol 54:23–30. https://doi.org/10.1007/s00795-020-00256-4

    Article  CAS  PubMed  Google Scholar 

  37. Bishop JA, Yonescu R, Batista DAS et al (2013) Cytopathologic features of mammary analogue secretory carcinoma. Cancer Cytopathol 121:228–233. https://doi.org/10.1002/cncy.21245

    Article  CAS  PubMed  Google Scholar 

  38. Jung MJ, Song JS, Kim SY et al (2013) Finding and characterizing mammary analogue secretory carcinoma of the salivary gland. Korean J Pathol 47:36–43. https://doi.org/10.4132/KoreanJPathol.2013.47.1.36

    Article  PubMed  PubMed Central  Google Scholar 

  39. Alves LDB, de Melo AC, Farinha TA et al (2020) A systematic review of secretory carcinoma of the salivary gland: where are we? Oral Surg Oral Med Oral Pathol Oral Radiol. https://doi.org/10.1016/j.oooo.2020.04.007

    Article  PubMed  Google Scholar 

  40. Ngouajio AL, Drejet SM, Phillips DR et al (2017) A systematic review including an additional pediatric case report: pediatric cases of mammary analogue secretory carcinoma. Int J Pediatr Otorhinolaryngol 100:187–193. https://doi.org/10.1016/j.ijporl.2017.07.004

    Article  PubMed  Google Scholar 

  41. Sawabe M, Ito H, Takahara T et al (2018) Heterogeneous impact of smoking on major salivary gland cancer according to histopathological subtype: a case-control study. Cancer 124:118–124. https://doi.org/10.1002/cncr.30957

    Article  PubMed  Google Scholar 

  42. Speight PM (1992) World health organization international histological classification of tumours: histological typing of salivary gland tumours. G. Seifert (Ed.). Springer-Verlag, Heidelberg, 1991. No. of pages: 112. Price: DM 68. ISBN: 0 387 54031. The Journal of Pathology 168:88–88

  43. Hsieh M-S, Chou Y-H, Yeh S-J, Chang Y-L (2015) Papillary-cystic pattern is characteristic in mammary analogue secretory carcinomas but is rarely observed in acinic cell carcinomas of the salivary gland. Virchows Arch 467:145–153. https://doi.org/10.1007/s00428-015-1786-8

    Article  CAS  PubMed  Google Scholar 

  44. Skalova A, Michal M, Simpson RH (2017) Newly described salivary gland tumors. Mod Pathol 30:S27–S43. https://doi.org/10.1038/modpathol.2016.167

    Article  PubMed  Google Scholar 

  45. Tartaglione T, Botto A, Sciandra M, et al (2015) Differential diagnosis of parotid gland tumours: which magnetic resonance findings should be taken in account? Acta Otorhinolaryngol Ital 35:314–320. https://doi.org/10.14639/0392-100X-693

  46. Minami M, Tanioka H, Oyama K et al (1993) Warthin tumor of the parotid gland: MR-pathologic correlation. AJNR Am J Neuroradiol 14:209–214

    CAS  PubMed  PubMed Central  Google Scholar 

  47. Baba A, Kessoku H, Akutsu T et al (2021) Correction to: pre-treatment MRI predictor of high-grade malignant parotid gland cancer. Oral Radiol. https://doi.org/10.1007/s11282-021-00512-y

    Article  PubMed  Google Scholar 

  48. Ishibashi M, Fujii S, Kawamoto K et al (2010) Capsule of parotid gland tumor: evaluation by 3.0 T magnetic resonance imaging using surface coils. Acta radiol 51:1103–1110. https://doi.org/10.3109/02841851.2010.519716

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Neuroradiology, Department of Radiology, University of Michigan, 1500 E Medical Center Dr, UH B2, Ann Arbor, MI, 48109, USA

    Ryo Kurokawa, Mariko Kurokawa, Akira Baba, Yoshiaki Ota, Toshio Moritani & Ashok Srinivasan

Authors
  1. Ryo Kurokawa
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Mariko Kurokawa
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Akira Baba
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Yoshiaki Ota
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Toshio Moritani
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Ashok Srinivasan
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

• Conceptualization: Ryo Kurokawa.

• Data curation: Ryo Kurokawa, Mariko Kurokawa, Akira Baba, Yoshiaki Ota.

• Methodology: Ryo Kurokawa, Mariko Kurokawa, Akira Baba.

• Formal analysis and investigation: Ryo Kurokawa, Mariko Kurokawa.

• Writing—original draft preparation: Ryo Kurokawa.

• Writing—review and editing: Yoshiaki Ota, Toshio Moritani, Ashok Srinivasan.

• Supervision: Ashok Srinivasan.

Corresponding author

Correspondence to Ryo Kurokawa.

Ethics declarations

Competing interests

All authors declare that they have no competing interests.

Ethics approval

The study was approved by the ethics committee of the University of Michigan, in accordance with a waiver of informed consent. Data were de-identified prior to any analysis.

Consent for publication

All authors gave consent for publication.

Additional information

Publisher's note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Supplementary Information

Below is the link to the electronic supplementary material.

Supplementary file1 (PDF 81 kb)

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Kurokawa, R., Kurokawa, M., Baba, A. et al. Radiological features of head and neck mammary analogue secretory carcinoma: 11 new cases with a systematic review of 29 cases reported in 28 publications. Neuroradiology 63, 1901–1911 (2021). https://doi.org/10.1007/s00234-021-02796-7

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00234-021-02796-7

Keywords

Search

Navigation