Skip to main content
SpringerLink
Log in

Properties, Expression and Potential Roles of Cardiac K+ Channel Accessory Subunits: MinK, MiRPs, KChIP, and KChAP

  • Published:
The Journal of Membrane Biology Aims and scope Submit manuscript

Abstract

Over the past 10 years, cDNAs encoding a wide range of pore-forming K+-channel α-subunits have been cloned and found to result in currents with many properties of endogenous cardiac K+ channels upon homomeric expression in heterologous systems. However, a variety of remaining discrepancies have led to a search for other subunits that might be involved in the formation of native channels. Over the past few years, a series of accessory subunits has been discovered that modify current properties upon coexpression with α-subunits. One of these, the minimal K+-channel subunit minK, is essential for formation of the cardiac slow delayed-rectifier K+ current, I Ks, and may also interact in functionally important ways with other α-subunits. Another, the K+-channel interacting protein KChIP appears critical in formation of native transient outward current (I to) channels. The roles of 2 other accessory subunits, the minK-related peptide MiRP and the K+-channel accessory protein, KChAP, remain unclear. This article reviews the available knowledge regarding the accessory subunits minK, MiRP, KChIP and KChAP, dealing with their structure, effects on currents carried by coexpressed α-subunits, expression in cardiac tissues and potential physiological function. On the basis of the available information, we attempt to assess the potential involvement of these accessory K+-channel subunits in cardiac pathophysiology and in developing new therapeutic approaches.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1
Figure 2

References

  1. G.W. Abbott M.H. Butler S. Bendahhou M.C. Dalakas L.J. Ptacek S.A. Goldstein (2001) ArticleTitle. Cell 104 217–231 Occurrence Handle1:CAS:528:DC%2BD3MXis1Kmu7g%3D Occurrence Handle11207363

    CAS  PubMed  Google Scholar 

  2. G.W. Abbott S.A. Goldstein (2002) ArticleTitle. FASEB J. 16 390–400 Occurrence Handle10.1096/fj.01-0520hyp Occurrence Handle1:CAS:528:DC%2BD38XhvVCmu78%3D Occurrence Handle11874988

    Article  CAS  PubMed  Google Scholar 

  3. G.W. Abbott F. Sesti I. Splawski M.E. Buck M.H. Lehmann K.W. Timothy M.T. Keating S.A. Goldstein (1999) ArticleTitle. Cell 97 175–187 Occurrence Handle1:CAS:528:DyaK1MXislentrc%3D Occurrence Handle10219239

    CAS  PubMed  Google Scholar 

  4. I. Abitbol A. Peretz C. Lerche A.E. Busch B. Attali (1999) ArticleTitle. EMBO J. 18 4137–4148 Occurrence Handle10.1093/emboj/18.15.4137 Occurrence Handle1:CAS:528:DyaK1MXlt1Gqs7s%3D Occurrence Handle10428953

    Article  CAS  PubMed  Google Scholar 

  5. H. Abriel H. Motoike R.S. Kass (2000) ArticleTitle. Am. J. Physiol. 278 C863–C864 Occurrence Handle1:CAS:528:DC%2BD3cXjvFahurc%3D

    CAS  Google Scholar 

  6. W.F. An M.R. Bowlby M. Betty J. Cao H.P. Ling G. Mendoza J.W. Hinson K.I. Mattsson B.W. Strassle J.S. Trimmer K.J. Rhodes (2000) ArticleTitle. Nature 403 553–556 Occurrence Handle1:CAS:528:DC%2BD3cXht1Witr8%3D Occurrence Handle10676964

    CAS  PubMed  Google Scholar 

  7. C Antzelevitch (2001) ArticleTitle. J. Physiol. 533 1 Occurrence Handle1:STN:280:DC%2BD3M3lt1KktQ%3D%3D Occurrence Handle11351005

    CAS  PubMed  Google Scholar 

  8. B. Attali G. Romey E. Honore A. Schmid-Alliana M.G. Mattei F. Lesage P. Ricard J. Barhanin M. Lazdunski (1992) ArticleTitle. J. Biol. Chem. 267 8650–8657 Occurrence Handle1:CAS:528:DyaK3sXht1aru7c%3D Occurrence Handle1373731

    CAS  PubMed  Google Scholar 

  9. R. Bahring J. Dannenberg H.C. Peters T. Leicher O. Pongs D. Isbrandt (2001) ArticleTitle. J. Biol. Chem. 276 23888–23894 Occurrence Handle10.1074/jbc.M101320200 Occurrence Handle1:CAS:528:DC%2BD3MXltVWju70%3D Occurrence Handle11287421

    Article  CAS  PubMed  Google Scholar 

  10. J. Barhanin F. Lesage E. Guillemare M. Fink M. Lazdunski G. Romey (1996) ArticleTitle. Nature 384 78–80

    Google Scholar 

  11. A. Barth L. Zwermann S. Kaab M. Nabauer (2002) ArticleTitle. Circulation 106 II-90–II-90

    Google Scholar 

  12. E.M. Blumenthal L.K. Kaczmarek (1992) ArticleTitle. Neurochem. Res. 17 869–876 Occurrence Handle1:CAS:528:DyaK38XltVylsLc%3D Occurrence Handle1407274

    CAS  PubMed  Google Scholar 

  13. E.M. Blumenthal L.K. Kaczmarek (1994) ArticleTitle. J. Neurosci. 14 3097–3105 Occurrence Handle1:CAS:528:DyaK2cXltVCks78%3D Occurrence Handle7514215

    CAS  PubMed  Google Scholar 

  14. R.F. Bosch J.B. Grammer B. Eigenberger C. Mewis V. Kuehlkamp (1999) ArticleTitle. Circulation 100 I–632

    Google Scholar 

  15. A.E. Busch G.L. Busch E. Ford H. Suessbrich H.J. Lang R. Greger K. Kunzelmann B. Attali W. Stuhmer (1997) ArticleTitle. Br. J. Pharmacol. 122 187–189 Occurrence Handle1:CAS:528:DyaK2sXmtlyntbo%3D Occurrence Handle9313924

    CAS  PubMed  Google Scholar 

  16. A.E. Busch H. Suessbrich (1997) ArticleTitle. Trends Pharmacol. Sci. 18 26–29 Occurrence Handle10.1016/S0165-6147(96)01016-4 Occurrence Handle1:CAS:528:DyaK2sXht1Glt7s%3D Occurrence Handle9114727

    Article  CAS  PubMed  Google Scholar 

  17. A.E. Busch M.D. Varnum R.A. North J.P. Adelman (1992) ArticleTitle. Science 255 1705–1707 Occurrence Handle1:CAS:528:DyaK38XksVarsbo%3D Occurrence Handle1553557

    CAS  PubMed  Google Scholar 

  18. A.E. Busch S. Waldegger T. Herzer G. Raber E. Gulbins T. Takumi K. Moriyoshi S. Nakanishi F. Lang (1995) ArticleTitle. J. Biol. Chem. 270 3638–3641 Occurrence Handle10.1074/jbc.270.8.3638 Occurrence Handle1:CAS:528:DyaK2MXjvVyrs70%3D Occurrence Handle7876101

    Article  CAS  PubMed  Google Scholar 

  19. C.E. Chiang D.M. Roden (2000) ArticleTitle. J. Am. Coll. Cardiol. 36 1–12 Occurrence Handle10.1016/S0735-1097(00)00716-6 Occurrence Handle1:STN:280:DC%2BD3czlsVOksg%3D%3D Occurrence Handle10898405

    Article  CAS  PubMed  Google Scholar 

  20. J. Cui A. Kagan D. Qin J. Mathew Y.F. Melman T.V. McDonald (2001) ArticleTitle. J. Biol. Chem. 276 17244–17251 Occurrence Handle10.1074/jbc.M010904200 Occurrence Handle1:CAS:528:DC%2BD3MXjvFGitL0%3D Occurrence Handle11278781

    Article  CAS  PubMed  Google Scholar 

  21. J.E. Darnell Jr. I.M. Kerr G.R. Stark (1994) ArticleTitle. Science 264 1415–1421

    Google Scholar 

  22. N. Decher O. Uyguner C.R. Scherer B. Karaman M. Yuksel-Apak A.E. Busch K. Steinmeyer B. Wollnik (2001) ArticleTitle. Cardiovasc. Res. 52 255–264 Occurrence Handle10.1016/S0008-6363(01)00374-1 Occurrence Handle1:CAS:528:DC%2BD3MXnvFCqsLY%3D Occurrence Handle11684073

    Article  CAS  PubMed  Google Scholar 

  23. K. Dedek S. Waldegger (2001) ArticleTitle. Pfluegers Arch. 442 896–902 Occurrence Handle10.1007/s004240100609 Occurrence Handle1:CAS:528:DC%2BD3MXmslOktLs%3D

    Article  CAS  Google Scholar 

  24. S. Demolombe I. Baro Y. Pereon J. Bliek R. Mohammad-Panah H. Pollard S. Morid M. Mannens A. Wilde J. Barhanin F. Charpentier D. Escande (1998) ArticleTitle. J. Biol. Chem. 273 6837–6843 Occurrence Handle10.1074/jbc.273.12.6837 Occurrence Handle1:CAS:528:DyaK1cXitVGhs7c%3D Occurrence Handle9506986

    Article  CAS  PubMed  Google Scholar 

  25. I. Deschenes D. DiSilvestre G.J. Juang R.C. Wu W.F. An G.F. Tomaselli (2002) ArticleTitle. Circulation 106 423–429 Occurrence Handle10.1161/01.CIR.0000025417.65658.B6 Occurrence Handle1:CAS:528:DC%2BD38XmsVagur4%3D Occurrence Handle12135940

    Article  CAS  PubMed  Google Scholar 

  26. I. Deschenes G.F. Tomaselli (2002) ArticleTitle. FEES Lett. 528 183–188 Occurrence Handle1:CAS:528:DC%2BD38Xnt1Kltbo%3D

    CAS  Google Scholar 

  27. M.D. Drici I. Arrighi C. Chouabe J.R. Mann M. Lazdunski G. Romey J. Barhanin (1998) ArticleTitle. Circ. Res. 83 95–102 Occurrence Handle1:CAS:528:DyaK1cXks1Kktrw%3D Occurrence Handle9670922

    CAS  PubMed  Google Scholar 

  28. P. Duggal M.R. Vesely D. Wattanasirichaigoon J. Villafane V. Kaushik A.H. Beggs (1998) ArticleTitle. Circulation 97 142–146 Occurrence Handle1:CAS:528:DyaK1cXptF2ktQ%3D%3D Occurrence Handle9445165

    CAS  PubMed  Google Scholar 

  29. A. Felipe T.J. Knittle K.L. Doyle D.J. Snyders M.M. Tamkun (1994) ArticleTitle. Am. J. Physiol. 267 C700–C705 Occurrence Handle1:CAS:528:DyaK2MXisF2mur4%3D Occurrence Handle7943198

    CAS  PubMed  Google Scholar 

  30. M.R. Finley Y. Li F. Hua J. Lillich K.E. Mitchell S. Ganta R.F. Gilmour Jr. L.C. Freeman (2002) ArticleTitle. Am. J. Physiol. 283 H126–H138 Occurrence Handle1:CAS:528:DC%2BD38XlsVClu70%3D

    CAS  Google Scholar 

  31. K. Folander J.S. Smith J. Antanavage C. Bennett R.B. Stein R. Swanson (1990) ArticleTitle. Proc. Natl. Acad. Sci. USA 87 2975–2979 Occurrence Handle1:CAS:528:DyaK3cXkslahs7s%3D Occurrence Handle2183220

    CAS  PubMed  Google Scholar 

  32. D. Franco S. Demolombe S. Kupershmidt R. Dumaine J.N. Dominguez D. Roden C. Antzelevitch D. Escande A.F. Moorman (2001) ArticleTitle. Cardiovasc. Res. 52 65–75 Occurrence Handle10.1016/S0008-6363(01)00349-2 Occurrence Handle1:CAS:528:DC%2BD3MXms1Olt7k%3D Occurrence Handle11557234

    Article  CAS  PubMed  Google Scholar 

  33. L.C. Freeman R.S. Kass (1993) ArticleTitle. Circ. Res. 73 968–973 Occurrence Handle1:CAS:528:DyaK2cXls12k Occurrence Handle8403266

    CAS  PubMed  Google Scholar 

  34. T. Furukawa Y. Ono H. Tsuchiya Y. Katayama M.L. Bang D. Labeit S. Labeit N. Inagaki C.C. Gregorio (2001) ArticleTitle. J. Mol. Biol. 313 775–784 Occurrence Handle10.1006/jmbi.2001.5053 Occurrence Handle1:CAS:528:DC%2BD3MXotVyntLw%3D Occurrence Handle11697903

    Article  CAS  PubMed  Google Scholar 

  35. S.A. Goldstein C. Miller (1991) ArticleTitle. Neuron 7 403–408 Occurrence Handle1:CAS:528:DyaK38XlsFymsA%3D%3D Occurrence Handle1910787

    CAS  PubMed  Google Scholar 

  36. W. Guo H. Li F. Aimond D.C. Johns K.J. Rhodes J.S. Trimmer J.M. Nerbonne (2002) ArticleTitle. Circ. Res. 90 586–593 Occurrence Handle10.1161/01.RES.0000012664.05949.E0 Occurrence Handle1:CAS:528:DC%2BD38XisFWls74%3D Occurrence Handle11909823

    Article  CAS  PubMed  Google Scholar 

  37. W. Han W. Bao Z. Wang S. Nattel (2002) ArticleTitle. Circ. Res. 91 790–797 Occurrence Handle10.1161/01.RES.0000039534.18114.D9 Occurrence Handle1:CAS:528:DC%2BD38XotFKjsro%3D Occurrence Handle12411393

    Article  CAS  PubMed  Google Scholar 

  38. M.H. Holmqvist J. Cao R. Hernandez-Pineda M.D. Jacobson K.I. Carroll M.A. Sung M. Betty P. Ge K.J. Gilbride M.E. Brown M.E. Jurman D. Lawson L Silos-Santiago Y. Xie M. Covarrubias K.J. Rhodes P.S. Distefano W.F. An (2002) ArticleTitle. Proc. Natl. Acad. Sci. USA 99 1035–1040 Occurrence Handle10.1073/pnas.022509299 Occurrence Handle1:CAS:528:DC%2BD38Xht1Wit74%3D Occurrence Handle11805342

    Article  CAS  PubMed  Google Scholar 

  39. E. Honore B. Attali G. Romey C. Heurteaux P. Ricard F. Lesage M. Lazdunski J. Barhanin (1991) ArticleTitle. EMBO J. 10 2805–2811 Occurrence Handle1:CAS:528:DyaK38Xlt1yltb8%3D Occurrence Handle1655403

    CAS  PubMed  Google Scholar 

  40. M. Iwai M. Masu K. Tsuchida T. Mori H. Ohkubo S. Nakanishi (1990) ArticleTitle. J. Biochem. (Tokyo) 108 200–206 Occurrence Handle1:CAS:528:DyaK3cXlt1Oms7g%3D

    CAS  Google Scholar 

  41. L.K. Kaczmarek E.M Blumenthal (1997) ArticleTitle. Physiol. Rev. 77 627–641 Occurrence Handle1:CAS:528:DyaK2sXltlWlurw%3D Occurrence Handle9234960

    CAS  PubMed  Google Scholar 

  42. H.C. Kuo C.F. Cheng R.B. Clark J.J. Lin J.L. Lin M. Hoshijima V.T. Nguyen-Tran Y. Gu Y. Ikeda P.H. Chu J. Ross W.R. Giles K.R. Chien (2001) ArticleTitle. Cell 107 801–813 Occurrence Handle1:CAS:528:DC%2BD38XhtFylsg%3D%3D Occurrence Handle11747815

    CAS  PubMed  Google Scholar 

  43. S. Kupershmidt T. Yang M.E. Anderson A. Wessels K.D. Niswender M.A. Magnuson D.M. Roden (1999) ArticleTitle. Circ. Res. 84 146–152 Occurrence Handle1:CAS:528:DyaK1MXpsVGntg%3D%3D Occurrence Handle9933245

    CAS  PubMed  Google Scholar 

  44. J. Kurokawa H.K. Motoike R.S. Kass (2001) ArticleTitle. J. Gen. Physiol. 117 43–52 Occurrence Handle10.1085/jgp.117.1.43 Occurrence Handle1:STN:280:DC%2BD3M7gsl2nsA%3D%3D Occurrence Handle11134230

    Article  CAS  PubMed  Google Scholar 

  45. Y.A. Kuryshev T.I. Gudz A.M. Brown B.A. Wible (2000) ArticleTitle. Am. J. Physiol. 278 C931–C941 Occurrence Handle1:CAS:528:DC%2BD3cXjvFahu7Y%3D

    CAS  Google Scholar 

  46. Y.A. Kuryshev B.A. Wible T.I. Gudz A.N. Ramirez A.M. Brown (2001) ArticleTitle. Am. J. Physiol. 281 C290–C299 Occurrence Handle1:CAS:528:DC%2BD3MXltVKhsL8%3D

    CAS  Google Scholar 

  47. L.P. Lai C.L. Deng A.J. Moss R.S. Kass C.S. Liang (1994) ArticleTitle. Gene 151 339–340 Occurrence Handle10.1016/0378-1119(94)90685-8 Occurrence Handle1:CAS:528:DyaK2MXjtFSgs7g%3D Occurrence Handle7828904

    Article  CAS  PubMed  Google Scholar 

  48. L.P. Lai M.J. Su H.M. Yeh J.L. Lin F.T. Chiang J.J. Hwang K.L. Hsu C.D. Tseng W.P. Lien Y.Z. Tseng S.K. Huang (2002) ArticleTitle. Am. Heart J. 144 485–490 Occurrence Handle10.1067/mhj.2002.123573 Occurrence Handle1:CAS:528:DC%2BD38Xnsl2gs7c%3D Occurrence Handle12228786

    Article  CAS  PubMed  Google Scholar 

  49. C. Lerche G. Seebohm C.I. Wagner C.R. Scherer L. Dehmelt I. Abitbol U. Gerlach J. Brendel B. Attali A.E. Busch (2000) ArticleTitle. Br. J. Pharmacol. 131 1503–1506 Occurrence Handle1:CAS:528:DC%2BD3MXjtVGntA%3D%3D Occurrence Handle11139424

    CAS  PubMed  Google Scholar 

  50. F. Lesage B. Attali J. Lakey E. Honore G. Romey E. Faurobert M. Lazdunski J. Barhanin (1993) ArticleTitle. Receptors. Channels 1 143–152 Occurrence Handle1:CAS:528:DyaK2cXhsF2gtbg%3D Occurrence Handle8081718

    CAS  PubMed  Google Scholar 

  51. D. Li P. Melnyk J. Feng Z. Wang K. Petrecca A. Shrier S. Nattel (2000) ArticleTitle. Circulation 101 2631–2638 Occurrence Handle1:CAS:528:DC%2BD3cXks1SgsbY%3D Occurrence Handle10840016

    CAS  PubMed  Google Scholar 

  52. G.R. Li J. Feng L. Yue M. Carrier (1998) ArticleTitle. Am. J. Physiol. 275 H369–H377 Occurrence Handle1:CAS:528:DyaK1cXlsVOqu70%3D Occurrence Handle9683422

    CAS  PubMed  Google Scholar 

  53. D.W. Liu G.A. Gintant C. Antzelevitch (1993) ArticleTitle. Circ. Res. 72 671–687 Occurrence Handle1:STN:280:ByyC287ltVQ%3D Occurrence Handle8431990

    CAS  PubMed  Google Scholar 

  54. C.F. Lo R. Numann (1999) ArticleTitle. Ann. N. Y. Acad. Sci. 868 431–433 Occurrence Handle1:CAS:528:DyaK1MXjvFKitbk%3D Occurrence Handle10414315

    CAS  PubMed  Google Scholar 

  55. G. Loussouarn F. Charpentier R. Mohammad-Panah K. Kunzelmann I. Baro D. Escande (1997) ArticleTitle. Mol. Pharmacol. 52 1131–1136 Occurrence Handle1:CAS:528:DyaK1cXmtVGj Occurrence Handle9396783

    CAS  PubMed  Google Scholar 

  56. J.R. Martens Y.G. Kwak M.M. Tamkun (1999) ArticleTitle. TrendsCardiovasc. Med. 9 253–258 Occurrence Handle10.1016/S1050-1738(00)00037-2 Occurrence Handle1:CAS:528:DC%2BD3cXotlCrurw%3D

    Article  CAS  Google Scholar 

  57. R. Mazhari J.L. Greenstein R.L. Winslow E. Marban H.B. Nuss (2001) ArticleTitle. Circ. Res. 89 33–38 Occurrence Handle1:CAS:528:DC%2BD3MXltlSlurc%3D Occurrence Handle11440975

    CAS  PubMed  Google Scholar 

  58. R. Mazhari H.B. Nuss A.A. Armoundas R.L. Winslow E. Marban (2002) ArticleTitle. J. Clin. Invest 109 1083–1090 Occurrence Handle10.1172/JCI200215062 Occurrence Handle1:CAS:528:DC%2BD38XivFKjsb4%3D Occurrence Handle11956246

    Article  CAS  PubMed  Google Scholar 

  59. T.V. McDonald Z. Yu Z. Ming E. Palma M.B. Meyers K.W. Wang S.A. Goldstein G.I. Fishman (1997) ArticleTitle. Nature 388 289–292

    Google Scholar 

  60. T. Murai A. Kakizuka T. Takumi H. Ohkubo S. Nakanishi (1989) ArticleTitle. Biochem. Biophys. Res. Commun. 161 176–181 Occurrence Handle1:CAS:528:DyaK3cXkvFOjsQ%3D%3D Occurrence Handle2730656

    CAS  PubMed  Google Scholar 

  61. M. Nabauer D.J. Beuckelmann P. Uberfuhr G. Steinbeck (1996) ArticleTitle. Circulation 93 168–177 Occurrence Handle1:STN:280:BymC3cbgtFA%3D Occurrence Handle8616924

    CAS  PubMed  Google Scholar 

  62. S. Nattel (1999) ArticleTitle. J. Cardiovasc. Electrophysiol. 10 272–282 Occurrence Handle1:STN:280:DyaK1M7ovVKhsg%3D%3D Occurrence Handle10090234

    CAS  PubMed  Google Scholar 

  63. S. Nattel P. Khairy G. Schram (2001) ArticleTitle. TrendsCardiovasc. Med. 11 295–301 Occurrence Handle10.1016/S1050-1738(01)00134-7 Occurrence Handle1:CAS:528:DC%2BD3MXot1Omsr8%3D

    Article  CAS  Google Scholar 

  64. S. Nattel M.A. Quantz (1988) ArticleTitle. Cardiovasc. Res. 22 808–817 Occurrence Handle1:CAS:528:DyaL1MXltV2muw%3D%3D Occurrence Handle3256422

    CAS  PubMed  Google Scholar 

  65. S. Ohya Y. Morohashi K. Muraki T. Tomita M. Watanabe T. Iwatsubo Y. Imaizumi (2001) ArticleTitle. Biochem. Biophys. Res. Commun. 282 96–102 Occurrence Handle10.1006/bbrc.2001.4558 Occurrence Handle1:CAS:528:DC%2BD3MXitFeit7s%3D Occurrence Handle11263977

    Article  CAS  PubMed  Google Scholar 

  66. H. Ohyama H. Kajita K. Omori T. Takumi N. Hiramoto T. Iwasaka H. Matsuda (2001) ArticleTitle. PfluegersArch 442 329–335 Occurrence Handle10.1007/s004240100547 Occurrence Handle1:CAS:528:DC%2BD3MXkt1Kktrg%3D

    Article  CAS  Google Scholar 

  67. S. Oiki T. Takumi Y. Okada S. Nakanishi (1993) ArticleTitle. Ann. N. Y. Acad. Sci. 707 402–406 Occurrence Handle1:CAS:528:DyaK2MXhtlGhs7g%3D Occurrence Handle9137580

    CAS  PubMed  Google Scholar 

  68. D.M. Papazian T.L. Schwarz B.L. Tempel Y.N. Jan L.Y. Jan (1987) ArticleTitle. Science 237 749–753 Occurrence Handle1:CAS:528:DyaL2sXlsVygtbg%3D Occurrence Handle2441470

    CAS  PubMed  Google Scholar 

  69. S.P. Patel D.L. Campbell M.J. Morales H.C. Strauss (2002) ArticleTitle. J. Physiol. 539 649–656 Occurrence Handle10.1113/jphysiol.2001.015156 Occurrence Handle1:CAS:528:DC%2BD38Xjt1aqu7k%3D Occurrence Handle11897837

    Article  CAS  PubMed  Google Scholar 

  70. S.P. Patel D.L. Campbell H.C. Strauss (2002) ArticleTitle. J. Physiol. 545 5–11 Occurrence Handle10.1113/jphysiol.2002.031856 Occurrence Handle1:CAS:528:DC%2BD3sXktFeksA%3D%3D Occurrence Handle12433945

    Article  CAS  PubMed  Google Scholar 

  71. M. Pourrier W. Han S. Zicha Z. Wang S. Nattel (2002) ArticleTitle. Circulation 106 II–47

    Google Scholar 

  72. M. Pragnell K.J. Snay J.S. Trimmer N.J. MacLusky F. Naftolin L.K. Kaczmarek M.B. Boyle (1990) ArticleTitle. Neuron 4 807–812 Occurrence Handle1:CAS:528:DyaK3cXlt1Kks78%3D Occurrence Handle2344412

    CAS  PubMed  Google Scholar 

  73. C. Proenza D. Angoli E. Agranovich V. Macri E.A. Accili (2002) ArticleTitle. J. Biol. Chem. 277 5101–5109 Occurrence Handle10.1074/jbc.M106974200 Occurrence Handle1:CAS:528:DC%2BD38XhsFCjsrw%3D Occurrence Handle11741901

    Article  CAS  PubMed  Google Scholar 

  74. G. Romey B. Attali C. Chouabe I. Abitbol E. Guillemare J. Barhanin M. Lazdunski (1997) ArticleTitle. J. Biol. Chem. 272 16713–16716 Occurrence Handle10.1074/jbc.272.27.16713 Occurrence Handle1:CAS:528:DyaK2sXksVentb0%3D Occurrence Handle9201970

    Article  CAS  PubMed  Google Scholar 

  75. B. Rosati Z. Pan S. Lypen H.S. Wang I. Cohen J.E. Dixon D. McKinnon (2001) ArticleTitle. J. Physiol. 533 119–125 Occurrence Handle1:CAS:528:DC%2BD3MXjslylsbk%3D Occurrence Handle11351020

    CAS  PubMed  Google Scholar 

  76. M.C. Sanguinetti M.E. Curran A. Zou J. Shen P.S. Spector D.L. Atkinson M.T. Keating (1996) ArticleTitle. Nature 384 80–83

    Google Scholar 

  77. G. Schram M. Pourrier P. Melnyk S. Nattel (2002) ArticleTitle. Circ. Res. 90 939–950 Occurrence Handle10.1161/01.RES.0000018627.89528.6F Occurrence Handle1:CAS:528:DC%2BD38XjvFGksLw%3D Occurrence Handle12016259

    Article  CAS  PubMed  Google Scholar 

  78. G. Schram S. Zicha R. Bosch R. Dumaine C. Antzelevitch S. Nattel (2002) ArticleTitle. Biophysical Journal 82 605A–606A

    Google Scholar 

  79. B.C. Schroeder S. Waldegger S. Fehr M. Bleich R. Warth R. Greger T.J. Jentsch (2000) ArticleTitle. Nature 403 196–199 Occurrence Handle1:CAS:528:DC%2BD3cXmslWmsg%3D%3D Occurrence Handle10646604

    CAS  PubMed  Google Scholar 

  80. E. Schulze-Bahr Q. Wang H. Wedekind W. Haverkamp Q. Chen Y. Sun C. Rubie M. Hordt J.A. TowbiN M. Borggrefe G. Assmann X. Qu J.C. Somberg G. Breithardt C. Oberti H. Funke (1997) ArticleTitle. Nat. Genet. 17 267–268 Occurrence Handle1:CAS:528:DyaK2sXntVSht78%3D Occurrence Handle9354783

    CAS  PubMed  Google Scholar 

  81. F. Sesti G.W. Abbott J. Wei K.T. Murray S. Saksena P.J. Schwartz S.G. Priori D.M. Roden A.L. George Jr. S.A. Goldstein (2000) ArticleTitle. Proc. Natl. Acad. Sci. USA 97 10613–10618 Occurrence Handle10.1073/pnas.180223197 Occurrence Handle1:CAS:528:DC%2BD3cXms1CrtLw%3D Occurrence Handle10984545

    Article  CAS  PubMed  Google Scholar 

  82. F. Sesti S.A. Goldstein (1998) ArticleTitle. J. Gen. Physiol. 112 651–663 Occurrence Handle10.1085/jgp.112.6.651 Occurrence Handle1:CAS:528:DyaK1cXotFSgtLw%3D Occurrence Handle9834138

    Article  CAS  PubMed  Google Scholar 

  83. F. Sesti K.K. Tai S.A. Goldstein (2000) ArticleTitle. Biophys. J. 79 1369–1378 Occurrence Handle1:CAS:528:DC%2BD3cXmsVars74%3D Occurrence Handle10968999

    CAS  PubMed  Google Scholar 

  84. I. Splawski M. Tristani-Firouzi M.H. Lehmann M.C. Sanguinetti M.T. Keating (1997) ArticleTitle. Nat. Genet. 17 338–340 Occurrence Handle1:CAS:528:DyaK2sXntVSqtrY%3D Occurrence Handle9354802

    CAS  PubMed  Google Scholar 

  85. F. Spreafico J.J. Barski C. Farina M. Meyer (2001) ArticleTitle. Mol. Cell Neurosci. 17 1–16 Occurrence Handle10.1006/mcne.2000.0913 Occurrence Handle1:CAS:528:DC%2BD3MXlsVSmuw%3D%3D Occurrence Handle11161465

    Article  CAS  PubMed  Google Scholar 

  86. T. Sugimoto Y. Tanabe R. Shigemoto M. Iwai T. Takumi H. Ohkubo S. Nakanishi (1990) ArticleTitle. J. Membrane Biol 113 39–47 Occurrence Handle1:CAS:528:DyaK3cXhtFKhsrs%3D

    CAS  Google Scholar 

  87. R. Swanson J. Marshall J.S. Smith J.B. Williams M.B. Boyle K. Folander C.J. Luneau J. Antanavage C. Oliva S.A. Buhrow et al. (1990) ArticleTitle. Neuron 4 929–939 Occurrence Handle1:CAS:528:DyaK38Xlt1Gruw%3D%3D Occurrence Handle2361015

    CAS  PubMed  Google Scholar 

  88. K.K. Tai S.A. Goldstein (1998) ArticleTitle. Nature 391 605–608 Occurrence Handle10.1038/35416 Occurrence Handle1:CAS:528:DyaK1cXhtVSrsbs%3D Occurrence Handle9468141

    Article  CAS  PubMed  Google Scholar 

  89. K. Takimoto E.K. Yangi L. Conforti (2002) ArticleTitle. J. Biol. Chem. 277 26904–26911 Occurrence Handle10.1074/jbc.M203651200 Occurrence Handle1:CAS:528:DC%2BD38XlvV2isLc%3D Occurrence Handle12006572

    Article  CAS  PubMed  Google Scholar 

  90. T. Takumi K. Moriyoshi I. Aramori T. Ishii S. Oiki Y. Okada H. Ohkubo S. Nakanishi (1991) ArticleTitle. J. Biol. Chem. 266 22192–22198 Occurrence Handle1:CAS:528:DyaK3MXmtVCitL0%3D Occurrence Handle1939241

    CAS  PubMed  Google Scholar 

  91. T. Takumi H. Ohkubo S. Nakanishi (1988) ArticleTitle. Science 242 1042–1045 Occurrence Handle1:CAS:528:DyaL1MXksFWlsLw%3D Occurrence Handle3194754

    CAS  PubMed  Google Scholar 

  92. A.R. Tapper A.L. George Jr. (2000) ArticleTitle. J. Gen. Physiol. 116 379–390 Occurrence Handle10.1085/jgp.116.3.379 Occurrence Handle1:CAS:528:DC%2BD3cXms1Ogs7g%3D Occurrence Handle10962015

    Article  CAS  PubMed  Google Scholar 

  93. N. Tinel S. Diochot M. Borsotto M. Lazdunski J. Barhanin (2000) ArticleTitle. EMBO J. 19 6326–6330 Occurrence Handle10.1093/emboj/19.23.6326 Occurrence Handle1:CAS:528:DC%2BD3MXjtF2hsbY%3D Occurrence Handle11101505

    Article  CAS  PubMed  Google Scholar 

  94. M. Tristani-Firouzi M.C. Sanguinetti (1998) ArticleTitle. J. Physiol. 510 37–45 Occurrence Handle1:CAS:528:DyaK1cXkvVKksrg%3D Occurrence Handle9625865

    CAS  PubMed  Google Scholar 

  95. Y. Tsuji T. Opthof K. Kamiya K. Yasui W. Liu Z. Lu I. Kodama (2000) ArticleTitle. Cardiovasc. Res. 48 300–309 Occurrence Handle10.1016/S0008-6363(00)00180-2 Occurrence Handle1:CAS:528:DC%2BD3cXnsFWqtrs%3D Occurrence Handle11054476

    Article  CAS  PubMed  Google Scholar 

  96. J. Tyson L. Tranebjaerg S. Bellman C. Wren J.F. Taylor J. Bathen B. Aslaksen S.J. Sorland O. Lund S. Malcolm M. Pembrey S. Bhattacharya M. Bitner-Glindzicz (1997) ArticleTitle. Hum. Mol. Genet. 6 2179–2185 Occurrence Handle10.1093/hmg/6.12.2179 Occurrence Handle1:CAS:528:DyaK2sXntFejsbk%3D Occurrence Handle9328483

    Article  CAS  PubMed  Google Scholar 

  97. B.C. Valdez D. Henning L. Perlaky R.K. Busch H. Busch (1997) ArticleTitle. Biochem. Biophys. Res. Commun. 234 335–340 Occurrence Handle10.1006/bbrc.1997.6642 Occurrence Handle1:CAS:528:DyaK2sXjsFCjurw%3D Occurrence Handle9177271

    Article  CAS  PubMed  Google Scholar 

  98. M.D. Varnum A.E. Busch C.T. Bond J. Maylie J.P. Adelman (1993) ArticleTitle. Proc. Natl. Acad. Sci. USA 90 11528–11532 Occurrence Handle1:CAS:528:DyaK2cXnsVSmsg%3D%3D Occurrence Handle8265583

    CAS  PubMed  Google Scholar 

  99. P.G. Volders K.R. Sipido M.A. Vos R.L. Spatjens J.D. Leunissen E. Carmeliet H.J. Wellens (1999) ArticleTitle. Circulation 100 2455–2461 Occurrence Handle1:CAS:528:DC%2BD3cXisVKksw%3D%3D Occurrence Handle10595960

    CAS  PubMed  Google Scholar 

  100. S. Wang S.P. Patel Y. Qu P. Hua H.C. Strauss M.J. Morales (2002) ArticleTitle. Biochem. Biophys. Res. Commun. 295 223–229 Occurrence Handle10.1016/S0006-291X(02)00658-7 Occurrence Handle1:CAS:528:DC%2BD38XltFers7Y%3D Occurrence Handle12150935

    Article  CAS  PubMed  Google Scholar 

  101. M. Weerapura S. Nattel D. Chartier R. Caballero T.E. Hebert (2002) ArticleTitle. J. Physiol. 540 15–27 Occurrence Handle10.1113/jphysiol.2001.013296 Occurrence Handle1:CAS:528:DC%2BD38XjtFKgsLs%3D Occurrence Handle11927665

    Article  CAS  PubMed  Google Scholar 

  102. E. Wettwer G.J. Amos H. Posival U. Ravens (1994) ArticleTitle. Circ. Res. 75 473–482 Occurrence Handle1:STN:280:ByuA2c%2FnslA%3D Occurrence Handle8062421

    CAS  PubMed  Google Scholar 

  103. B.A. Wible L. Wang Y.A. Kuryshev A. Basu S. Haldar A.M. Brown (2002) ArticleTitle. J. Biol. Chem. 277 17852–17862 Occurrence Handle10.1074/jbc.M201689200 Occurrence Handle1:CAS:528:DC%2BD38XktVCntrc%3D Occurrence Handle11877452

    Article  CAS  PubMed  Google Scholar 

  104. B.A. Wible Q. Yang Y.A. Kuryshev E.A. Accili A.M. Brown (1998) ArticleTitle. J. Biol. Chem. 273 11745–11751 Occurrence Handle10.1074/jbc.273.19.11745 Occurrence Handle1:CAS:528:DyaK1cXjt1aisbw%3D Occurrence Handle9565597

    Article  CAS  PubMed  Google Scholar 

  105. G.G. Wilson A. Sivaprasadarao J.B. Findlay D. Wray (1994) ArticleTitle. FEBS Lett. 353 251–254 Occurrence Handle10.1016/0014-5793(94)01058-7 Occurrence Handle1:CAS:528:DyaK2MXitlWqtLY%3D Occurrence Handle7957868

    Article  CAS  PubMed  Google Scholar 

  106. T. Yang S. Kupershmidt D.M. Roden (1995) ArticleTitle. Circ. Res. 77 1246–1253 Occurrence Handle1:CAS:528:DyaK2MXpsFCitLo%3D Occurrence Handle7586238

    CAS  PubMed  Google Scholar 

  107. H. Yu J. Wu I. Potapova R.T. Wymore B. Holmes J. Zuckerman Z. Pan H. Wang W. Shi R.B. Robinson M.R. EI Maghrabi W. Benjamin J. Dixon D. McKinnon I.S. Cohen R. Wymore (2001) ArticleTitle. Circ. Res. 88 E84–E87 Occurrence Handle1:CAS:528:DC%2BD3MXltFKjsbw%3D Occurrence Handle11420311

    CAS  PubMed  Google Scholar 

  108. M. Zhang M. Jiang G.N. Tseng (2001) ArticleTitle. Circ. Res. 88 1012–1019 Occurrence Handle1:CAS:528:DC%2BD3MXktFOlsr8%3D Occurrence Handle11375270

    CAS  PubMed  Google Scholar 

  109. Z.J. Zhang N.K. Jurkiewicz K. Folander E. Lazarides J.J. Salata R. Swanson (1994) ArticleTitle. Proc. Natl. Acad. Sci. USA 91 1766–1770 Occurrence Handle1:CAS:528:DyaK2cXksFCntr0%3D Occurrence Handle7510407

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Research Center, Montreal Heart Institute, Montreal, Quebec, Canada H1T 1C8

    M. Pourrier, G. Schram & S. Nattel

Authors
  1. M. Pourrier
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. G. Schram
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. S. Nattel
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to S. Nattel.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Pourrier, M., Schram, G. & Nattel, S. Properties, Expression and Potential Roles of Cardiac K+ Channel Accessory Subunits: MinK, MiRPs, KChIP, and KChAP . J. Membrane Biol. 194, 141–152 (2003). https://doi.org/10.1007/s00232-003-2034-8

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00232-003-2034-8

Keywords

Search

Navigation