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Lansoprazole precipitated QT prolongation and torsade de pointes associated with disopyramide

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References

  1. Roden DM (2004) Drug-induced prolongation of the QT interval. N Engl J Med 350:1013–1022

    Article  PubMed  CAS  Google Scholar 

  2. Gremse DA (2001) Lansoprazole: pharmacokinetics, pharmacodynamics and clinical uses. Expert Opin Pharmacother 2(10):1663–1670

    Article  PubMed  CAS  Google Scholar 

  3. Blume H, Donath F, Warnke A, Schug BS (2006) Pharmacokinetic drug interaction profiles of proton pump inhibitors. Drug Saf 29:769–784

    Article  PubMed  CAS  Google Scholar 

  4. Shi S, Klotz U (2008) Proton pump inhibitors: an update of their clinical use and pharmacokinetics. Eur J Clin Pharmacol 64:935–951

    Article  PubMed  CAS  Google Scholar 

  5. Letsas KP, Efremidis M, Kounas SP, Pappas LK, Gavrielatos G, Alexanian IP, Dimopoulos NP, Filippatos GS, Sideris A, Kaedaras F (2009) Clinical characteristics of patients with drug-induced QT interval prolongation and torsade de pointes: identification of risk factors. Clin Res Cardiol 98:208–212

    Article  PubMed  Google Scholar 

  6. Gupta A, Lawrence AT, Krishnan K, Kavinsky CJ, Trohman RG (2007) Current concepts in the mechanisms and management of drug-induced QT prolongation and torsade de pointes. Am Heart J 153:891–899

    Article  PubMed  Google Scholar 

  7. Kannankeril PJ, Roden DM (2007) Drug-induced long QT and torsade de pointes: recent advances. Curr Opin Cardiol 22:39–43

    Article  PubMed  Google Scholar 

  8. Johnson JN, Grifoni C, Bos JM, Saber-Ayad M, Ommen SR, Nistri S, Cecchi F, Olivotto I, Ackerrman MJ (2011) Prevalence and clinical correlates of QT prolongation in patients with hypertrophic cardiomyopathy. Eur Heart J 32:1114–1121

    Article  PubMed  Google Scholar 

  9. Dritsas A, Sbarouni E, Gilligan D, Nihoyannopoulos P, Oakley CM (1992) QT-interval abnormalities in hypertrophic cardiomyopathy. Clin Cardiol 15:739–742

    Article  PubMed  CAS  Google Scholar 

  10. Sherrid MV, Barac I, McKenna WJ, Elliott PM, Dickie S, Chojnowska L, Casey S, Maron BJ (2005) Multicenter study of the efficacy and safety of disopytamide in obstructive hypertrophic cardiomyopathy. J Am Coll Cardiol 45:1251–1258

    Article  PubMed  CAS  Google Scholar 

  11. Trujillo TC, Nolan PE (2000) Antiarrhythmic agents: drug interactions of clinical significance. Drug Saf 23:509–532

    Article  PubMed  CAS  Google Scholar 

  12. Guo Z, Raeissi S, White RB, Stevens JC (1997) Orphenadrine and methimazole inhibit multiple cytochrome P450 enzymes in human liver microsomes. Drug Metab Dispos 25:390–393

    PubMed  Google Scholar 

  13. Cundy T, Dissanayake A (2008) Severe hypomagnesaemia in long-term users of proton-pump inhibitors. Clin Endoclinol 69:338–341

    Article  CAS  Google Scholar 

  14. Mackay JD, Bladon PT (2010) Hypomagnesaemia due to proton-pump inhibitor therapy: a clinical case series. QJM 103:387–395

    Article  PubMed  CAS  Google Scholar 

  15. Broeren MA, Geerdink EA, Vader HL, van den Wall Bake AW (2009) Hypomagnesemia induced by several proton-pump inhibitors. Ann Intern Med 151:755–756

    PubMed  Google Scholar 

  16. Siddoway LA, Woosley RL (1986) Clinical pharmacokinetics of disopyramide. Clin Pharmacokinet 11:214–222

    Article  PubMed  CAS  Google Scholar 

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Correspondence to Hiroshi Asajima.

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Asajima, H., Saito, N., Ohmura, Y. et al. Lansoprazole precipitated QT prolongation and torsade de pointes associated with disopyramide. Eur J Clin Pharmacol 68, 331–333 (2012). https://doi.org/10.1007/s00228-011-1119-z

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