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Interaction of clozapine and ciprofloxacin: a case report

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References

  1. Markowitz JS, Gill HS, Devane CL et al (1997) Fluoroquinolone inhibition of clozapine metabolism. Am J Psychiatry 154(6):881

    PubMed  CAS  Google Scholar 

  2. Jecel J, Michel TM, Gutknecht L et al (2005) Toxic clozapine serum levels during acute urinary tract infection: a case report. Eur J Clin Pharmacol 60:909–910

    Article  PubMed  Google Scholar 

  3. Raaska K, Neuvonen PJ (2000) Ciprofloxacin increases serum clozapine and N-desmethylclozapine: a study in patients with schizophrenia. Eur J Clin Pharmacol 56(8):585–589

    Article  PubMed  CAS  Google Scholar 

  4. Raaska K, Raitasuo V, Arstila M et al (2002) Bacterial pneumonia can increase serum concentration of clozapine. Eur J Clin Pharmacol 58:321–322

    Article  PubMed  CAS  Google Scholar 

  5. Revised UK national guidelines on sexually transmitted infections & closely related conditions 2002

  6. Spina E, Avenoso A, Facciola G et al (2000) Relationship between plasma concentrations of clozapine and norclozapine and therapeutic response in patients with schizophrenia resistant to conventional neuroleptics. Psychopharmacology 148(1):83–89

    Article  PubMed  CAS  Google Scholar 

  7. McCarthy PT, Hughes S, Paton C (1995) Measurement of clozapine & norclozapine by high performance liquid chromatography with ultraviolet detection. Biomed Chromatogr 9(1):36–41

    Article  PubMed  CAS  Google Scholar 

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Acknowledgement

The authors sincerely thank Dr. Edgar P. Spencer, principal clinical scientist, Medical Toxicology Unit, Guy’s & St. Thomas NHS Foundation Trust, Avonley Road, London, for his contribution into the information about the analytical method and molar concentration ratios.

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Authors and Affiliations

  1. Caswell Clinic, Bridgend, Mid Glamorgan, UK

    Rajvinder S. Sambhi, Ramneesh Puri & Gaynor Jones

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  1. Rajvinder S. Sambhi
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  2. Ramneesh Puri
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  3. Gaynor Jones
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Correspondence to Rajvinder S. Sambhi.

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Sambhi, R.S., Puri, R. & Jones, G. Interaction of clozapine and ciprofloxacin: a case report. Eur J Clin Pharmacol 63, 895–896 (2007). https://doi.org/10.1007/s00228-007-0313-5

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  • DOI: https://doi.org/10.1007/s00228-007-0313-5

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