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Dietary-Induced Metabolic Acidosis Decreases Bone Mineral Density in Mature Ovariectomized Ewes

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Abstract

Dietary-induced metabolic acidosis (DIMA) may be a significant confounder in the development of osteoporosis. Diets that are acidifying are typically rich in proteins and grains and relatively poor in fruits and vegetables. Previous studies have not examined whether an interaction between estrogen depletion and DIMA have a compounded affect on bone mineral density loss. Sheep have been used successfully in previous studies to examine the interaction of bone turnover and ovariectomy. Therefore, the goal of this pilot study was to determine if bone mineral density (BMD) loss could be induced using DIMA in skeletally mature ovariectomized (OVX) ewes.

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References

  1. L Melton E Chrischilles C Cooper et al. (1992) ArticleTitleHow many women have osteoporosis? J Bone Miner Res 7 1005–1010 Occurrence Handle1414493

    PubMed  Google Scholar 

  2. S New (2002) ArticleTitleThe role of the skeleton in acid-base homeostasis Proceedings of the Nutrition Society 61 151–164 Occurrence Handle10.1079/PNS2002159 Occurrence Handle1:CAS:528:DC%2BD38XltlOrurc%3D Occurrence Handle12133196

    Article  CAS  PubMed  Google Scholar 

  3. J Lemann J Litzow E Lennon (1966) ArticleTitleThe effects of chronic acid loads in normal man: further evidence for the participation of bone mineral in the defense against chronic metabolic acidosis J Clin Invest 45 1608–1614 Occurrence Handle1:CAS:528:DyaF28XkvFehtbw%3D Occurrence Handle5927117

    CAS  PubMed  Google Scholar 

  4. A Sebastian S Harris J Ottaway et al. (1994) ArticleTitleImproved mineral balance and skeletal metabolism in postmenopausal women treated with potassium bicarbonate N Engl J Med 23 1776–1781 Occurrence Handle10.1056/NEJM199406233302502

    Article  Google Scholar 

  5. J Vaitkevicius R Witt M Maasadam et al. (2002) ArticleTitleEthnic differences in titratable acid excretion and bone mineralization Med Sci Sports Exerc 34 295–302

    Google Scholar 

  6. MJ Fettman (2000) ArticleTitleDietary instead of pharmacological management to counter the adverse effects of physiological adaptations to space flight Pflugers Arch-Eur J Physiol 441 IssueIDsuppl R15–R20 Occurrence Handle1:CAS:528:DC%2BD3cXoslequrw%3D

    CAS  Google Scholar 

  7. S Whiting H Draper (1981) ArticleTitleEffect of chronic high protein feeding on bone composition in the adult rat J Nutr 111 178–183 Occurrence Handle1:CAS:528:DyaL3MXot1OjsA%3D%3D Occurrence Handle7452369

    CAS  PubMed  Google Scholar 

  8. P Stewart (1981) How to understand acid base balance P Stewart (Eds) A Quantitative Acid-Base Primer for Biology and Medicine Elsevier New York

    Google Scholar 

  9. P Stewart (1983) ArticleTitleModern quantitative acid-base chemistry Canad J Physiol Pharmacol 61 1444–1461 Occurrence Handle1:CAS:528:DyaL2cXit1Gn

    CAS  Google Scholar 

  10. T Arnett (2003) ArticleTitleRegulation of bone cell function by acid-base balance Proc Nutr Soc 62 511–520 Occurrence Handle10.1079/PNS2003268 Occurrence Handle1:CAS:528:DC%2BD3sXmt1Glsrk%3D Occurrence Handle14506899

    Article  CAS  PubMed  Google Scholar 

  11. JP Goff RL Horst FJ Mueller (1991) ArticleTitleAddition of chloride to a prepartal diet high in cations increases 1,25-dihydroxyvitamin D response to hypocalcemia preventing milk fever J Dairy Sci 74 3863–3871 Occurrence Handle1:CAS:528:DyaK38XitVSrug%3D%3D Occurrence Handle1757627

    CAS  PubMed  Google Scholar 

  12. T Remer F Manz (1995) ArticleTitlePotential renal acid load of foods and its influence on urine pH J Am Diet Assoc 95 791–797 Occurrence Handle10.1016/S0002-8223(95)00219-7 Occurrence Handle1:STN:280:ByqA3Mfkt1Q%3D Occurrence Handle7797810

    Article  CAS  PubMed  Google Scholar 

  13. W Ganong (2001) Regulation of extracellular fluid composition and volume GanongWF (Eds) Review of Medical Physiology Lange Medical Books-McGraw Hill Medical Publishing Division New York 704–712

    Google Scholar 

  14. L Frassetto K Todd RJ Morris A Sebastian (1998) ArticleTitleEstimation of net endogenous noncarbonic acid production in humans from diet potassium and protein contents Am J Clin Nutr 68 576–583 Occurrence Handle1:CAS:528:DyaK1cXlvFWnsro%3D Occurrence Handle9734733

    CAS  PubMed  Google Scholar 

  15. J Riond (2001) ArticleTitleAnimal nutrition and acid base balance Eur J Nutr 40 245–254 Occurrence Handle10.1007/s394-001-8352-2 Occurrence Handle1:CAS:528:DC%2BD38XitVGns7Y%3D Occurrence Handle11842950

    Article  CAS  PubMed  Google Scholar 

  16. J Dwyer E Foulkes M Evans L Ausman (1985) ArticleTitleAcid/Alkaline ash diets: time for assessment and change J Am Diet Assoc 85 841–845 Occurrence Handle1:STN:280:BiqB3srjsFY%3D Occurrence Handle4008836

    CAS  PubMed  Google Scholar 

  17. S Boyd Eaton L Cordain (1997) ArticleTitleEvolutionary aspects of diet: old genes, new fuels World Rev Nutr Diet 81 26–37 Occurrence Handle9287501

    PubMed  Google Scholar 

  18. D Bushinsky (1996) ArticleTitleMetabolic alkalosis decreases bone calcium efflux by suppressing osteoclasts and stimulating osteoblasts Am J Physiol 271 F216–F222 Occurrence Handle1:CAS:528:DyaK28XkvVWht7c%3D Occurrence Handle8760264

    CAS  PubMed  Google Scholar 

  19. D Bushinsky (2001) ArticleTitleChronic acidosis: calcium release Eur J Nutr 40 240–244 Occurrence Handle10.1007/s394-001-8351-5

    Article  Google Scholar 

  20. AS Turner M Alvis W Myers et al. (1995) ArticleTitleChanges in bone mineral density and bone-specific alkaline phosphatase in ovariectomized ewes Bone 17 395S–402S Occurrence Handle10.1016/8756-3282(95)98424-L Occurrence Handle1:CAS:528:DyaK2MXptlKjt78%3D Occurrence Handle8579943

    Article  CAS  PubMed  Google Scholar 

  21. AS Turner M Alvis C Mallinckrodt H Bryant (1995) ArticleTitleDual-energy x-ray absorptiometry in sheep: experiences with in vivo and in vitro studies Bone 17 IssueIDsuppl 381S–387S Occurrence Handle10.1016/8756-3282(95)98422-J Occurrence Handle1:STN:280:BymC3MbitFI%3D Occurrence Handle8579941

    Article  CAS  PubMed  Google Scholar 

  22. AS Turner M Alvis C Mallinckrodt H Bryant (1995) ArticleTitleDose response effects of estradiol on bone mineral density in ovariectomized ewes Bone 17 421S–427S Occurrence Handle10.1016/8756-3282(95)98428-P Occurrence Handle1:CAS:528:DyaK2MXptlKjt7o%3D Occurrence Handle8579947

    Article  CAS  PubMed  Google Scholar 

  23. Committee on Care and Use of Laboratory Animals of the ILAR (1985) Guide for the Care and Use of Laboratory Animals. US Dept of Health and Human Services, Public Health Service, National Institutes of Health

  24. InstitutionalAuthorNameAVMA (1993) ArticleTitlePanel on Euthanasia J Am Vet Med Assoc 202 229–249

    Google Scholar 

  25. Littell RC, Ramon C, Milliken GA, Stroup WW (1996) The SAS system for mixed models. SAS Institute Inc., Cary, NC

  26. D Davey (1998) ArticleTitleOsteoporosis in clinical practice—bone densitometry and fracture risk S Afr Med J 88 1419–1423 Occurrence Handle1:STN:280:DyaK1M%2FnvV2nsw%3D%3D Occurrence Handle9861948

    CAS  PubMed  Google Scholar 

  27. Turner AS (2001) Research in orthopedic surgery. In: Surgical Research.,

  28. AS Turner (2001) ArticleTitleAnimal models of osteoporosis—necessity and limitations Eur Cells Materials 1 66–81 Occurrence Handle1:CAS:528:DC%2BD3MXnsFyrsLw%3D

    CAS  Google Scholar 

  29. AS Turner (2002) ArticleTitleThe sheep as a model for osteoporosis in humans The Vet J 163 1–8 Occurrence Handle10.1053/tvjl.2001.0688

    Article  Google Scholar 

  30. N Taechakraichana K Limpaphayom U Jaisamrarn M Poshyachinda (1997) ArticleTitleBone loss in oophorectomized Thai women J Med Assoc Thai 80 384–390 Occurrence Handle1:STN:280:ByiA1cvitV0%3D Occurrence Handle9240013

    CAS  PubMed  Google Scholar 

  31. A Yildiz I Sahin K Gol et al. (1996) ArticleTitleBone loss rate in the lumbar spine: a comparison between natural and surgically induced menopause Int J Gynaecol Obstet 55 153–159 Occurrence Handle10.1016/S0020-7292(96)02756-7 Occurrence Handle1:STN:280:ByiC38%2Fjt1I%3D Occurrence Handle8960997

    Article  CAS  PubMed  Google Scholar 

  32. CA Lill AK Fluegel E Schneider (2000) ArticleTitleSheep model for fracture treatment in osteoporotic bone: a pilot study about different induction regimens J Orthop Trauma 14 559–565 Occurrence Handle10.1097/00005131-200011000-00007 Occurrence Handle1:STN:280:DC%2BD3M7ptV2gsw%3D%3D Occurrence Handle11149502

    Article  CAS  PubMed  Google Scholar 

  33. K Leung W Siu N Cheung et al. (2001) ArticleTitleGoats as an osteopenic animal model J Bone Miner Res 16 2348–2355 Occurrence Handle1:CAS:528:DC%2BD38XhtlShtQ%3D%3D Occurrence Handle11760851

    CAS  PubMed  Google Scholar 

  34. L Dalle Carbonare M Arlot P Chavassieux et al. (2001) ArticleTitleComparison of trabecular bone microarchitecture and remodeling in glucocorticoid-induced and postmenopausal osteoporosis J Bone Miner Res 16 97–103 Occurrence Handle11149495

    PubMed  Google Scholar 

  35. U Barzel (1995) ArticleTitleThe skeleton as an ion exchange system: implications for the role of acid-base imbalance in the genesis of osteoporosis J Bone Miner Res 10 1431–1436 Occurrence Handle1:STN:280:BymC3Mrps10%3D Occurrence Handle8686497

    CAS  PubMed  Google Scholar 

  36. L Frassetto RJ Morris D Sellmeyer et al. (2001) ArticleTitleDiet, evolution and aging: the pathophysiolgic effects of post-agricultural inversion of the potassium-to-sodium and base-to-chloride ratios in the human diet Eur J Nutr 40 200–213 Occurrence Handle10.1007/s394-001-8347-4 Occurrence Handle1:CAS:528:DC%2BD38XitVGns70%3D Occurrence Handle11842945

    Article  CAS  PubMed  Google Scholar 

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Acknowledgments

Funding was provided by the Colorado Research Council, Stryker Biotech, Inc., National Institutes of Health (R01-AR47434-01).

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Authors and Affiliations

  1. Departments of Clinical Sciences, Colorado State University, Fort Collins, CO, 80523, USA

    J.M. MacLeay, R.M. Enns & A.S. Turner

  2. Department of Engineering, Colorado State University, Fort Collins, CO, 80523, USA

    D.L. Wheeler

  3. Independent Consultant, Fort Collins, CO, 80523, USA

    J.D. Olson

  4. Henry Ford Hospital, Detroit, MI, USA

    C.M. Les

  5. Stryker Biotech, Inc., Hopkinton, MA, USA

    C.A. Toth

Authors
  1. J.M. MacLeay
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  2. J.D. Olson
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  3. R.M. Enns
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  4. C.M. Les
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  5. C.A. Toth
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  6. D.L. Wheeler
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  7. A.S. Turner
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Correspondence to J.M. MacLeay.

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MacLeay, J., Olson, J., Enns, R. et al. Dietary-Induced Metabolic Acidosis Decreases Bone Mineral Density in Mature Ovariectomized Ewes . Calcif Tissue Int 75, 431–437 (2004). https://doi.org/10.1007/s00223-004-0217-7

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  • DOI: https://doi.org/10.1007/s00223-004-0217-7

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