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Bioanalytical methods for circulating extracellular matrix-related proteins: new opportunities in cancer diagnosis

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Abstract

The role of the extracellular matrix (ECM) remodeling in tumorigenesis and metastasis is becoming increasingly clear. Cancer development requires that tumor cells recruit a tumor microenvironment permissive for further tumor growth. This is a dynamic process that takes place by a cross-talk between tumor cells and ECM. As a consequence, molecules derived from the ECM changes associated to cancer are released into the bloodstream, representing potential biomarkers of tumor development. This article highlights the importance of developing and improving bioanalytical methods for the detection of ECM remodeling-derived components, as a step forward to translate the basic knowledge about cancer progression into the clinical practice.

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Acknowledgements

R.L.-G. thanks the Spanish Government for a predoctoral FPU fellowship (FPU16/05670).

Funding

The work was funded by the Spanish Ministerio de Ciencia y Universidades (RTI-2018-095756-B-I00).

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Authors and Affiliations

  1. Departamento de Química Física y Analítica, Universidad de Oviedo, Av. Julián Clavería 8, 33006, Oviedo, Spain

    Ramón Lorenzo-Gómez, Rebeca Miranda-Castro, Noemí de-los-Santos-Álvarez & María Jesús Lobo-Castañón

  2. Instituto de Investigación Sanitaria del Principado de Asturias, Avenida de Roma, 33011, Oviedo, Spain

    Ramón Lorenzo-Gómez, Rebeca Miranda-Castro, Noemí de-los-Santos-Álvarez & María Jesús Lobo-Castañón

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  1. Ramón Lorenzo-Gómez
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  2. Rebeca Miranda-Castro
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  3. Noemí de-los-Santos-Álvarez
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  4. María Jesús Lobo-Castañón
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Correspondence to María Jesús Lobo-Castañón.

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Lorenzo-Gómez, R., Miranda-Castro, R., de-los-Santos-Álvarez, N. et al. Bioanalytical methods for circulating extracellular matrix-related proteins: new opportunities in cancer diagnosis. Anal Bioanal Chem 414, 147–165 (2022). https://doi.org/10.1007/s00216-021-03416-2

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  • DOI: https://doi.org/10.1007/s00216-021-03416-2

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