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NMR measurements of diffusion in concentrated samples: avoiding problems with radiation damping

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Abstract

Pulsed field gradient spin echo NMR is generally the method of choice for diffusion measurements on liquid samples. With modern high field instruments, however, severe problems can arise when it is applied to samples with very high proton concentrations because of the presence of radiation damping. The problems may be greatly reduced by a suitable choice of experimental parameters, in particular the use of modified stimulated echo pulse sequences with a reduced flip angle for the first pulse.

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Acknowledgements

M.A.C. thanks the EPSRC and Pfizer Global Research and Development, Sandwich for a CASE award. This project was inspired by Prof. R.K. Harris, who kindly provided the siloxane sample, and with whom many helpful discussions are gratefully acknowledged.

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Authors and Affiliations

  1. Department of Chemistry, University of Manchester, Oxford Rd, Manchester , M13 9PL, United Kingdom

    Mark A. Connell & Gareth A. Morris

  2. Pfizer Global Research and Development, Sandwich, Kent, CT13 9NJ, United Kingdom

    Adrian L. Davis

  3. Department of Chemistry, University of Durham, Durham, DH1 3LE, United Kingdom

    Alan M. Kenwright

Authors
  1. Mark A. Connell
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  2. Adrian L. Davis
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  3. Alan M. Kenwright
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  4. Gareth A. Morris
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Correspondence to Gareth A. Morris.

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Connell, M.A., Davis, A.L., Kenwright, A.M. et al. NMR measurements of diffusion in concentrated samples: avoiding problems with radiation damping. Anal Bioanal Chem 378, 1568–1573 (2004). https://doi.org/10.1007/s00216-003-2387-y

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  • DOI: https://doi.org/10.1007/s00216-003-2387-y

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