Skip to main content

Advertisement

Log in

Essential value of cocaine and food in rats: tests of the exponential model of demand

  • Original Investigation
  • Published:
Psychopharmacology Aims and scope Submit manuscript

Abstract

Rationale

To provide a prospective test of the predictive adequacy of the exponential model of demand (Hursh and Silberberg, Psych Rev 115(1):186–198, 2008).

Objectives

In Experiment 1, to measure the ‘essential value’ (the propensity to defend consumption with changes in price) of cocaine and food in a demand analysis (functional relation between price and consumption) by means of the exponential model; in Experiment 2, to test whether the model’s systematic underestimation of cocaine consumption in Experiment 1 was due to weight loss; and in Experiment 3, to evaluate the effects of cocaine on the essential value of food.

Materials and methods

In Experiment 1, demand curves for food and cocaine were determined by measuring consumption of these goods in a multiple schedule over a range of fixed ratios; in Experiment 2, a demand curve for only cocaine was determined; and in Experiment 3, demand for food was determined in the absence of cocaine.

Results

In Experiment 1, the exponential equation accommodated high portions of variance for both curves, but systematically underestimated cocaine demand; in Experiment 2, this predictive underestimation of the equation was eliminated; and in Experiment 3, the essential value of food was greater than in Experiment 1.

Conclusions

The exponential model of demand accommodated the data variance for all cocaine and food demand curves. Compared to food, cocaine is a good of lower essential value.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6

Similar content being viewed by others

References

  • Ahmed SH, Cador M (2005) Dissociation of psychomotor sensitization from compulsive cocaine consumption. Neuropsychopharmacology 31(3):563–571

    Article  CAS  Google Scholar 

  • Ahmed SH, Koob GF (1998) Transition from moderate to excessive drug intake: change in hedonic set point. Science 282:298–301

    Article  PubMed  CAS  Google Scholar 

  • Ahmed SH, Koob GF (1999) Long-lasting increase in the set point for cocaine self-administration after escalation in rats. Psychopharmacology 146:303–312

    Article  PubMed  CAS  Google Scholar 

  • Aigner TG, Balster RL (1978) Choice behavior in rhesus monkeys: cocaine versus food. Science 201:534–535

    Article  PubMed  CAS  Google Scholar 

  • Balopole DC, Hansult CD, Dorph D (1979) Effect of cocaine on food intake in rats. Psychopharmacology 64:121–122

    Article  PubMed  CAS  Google Scholar 

  • Bergman J, Katz JL (1998) Behavioral pharmacology of cocaine and the determinants of abuse liability. In: Higgins ST, Katz JL (eds) Cocaine abuse: behavior, pharmacology, and clinical applications. Academic , New York, pp 51–79

    Google Scholar 

  • Childs E, Shoaib M, Stolerman IP (2006) Cocaine self-administration in rats with histories of cocaine exposure and discrimination. Psychopharmacology 286:168–176

    Article  CAS  Google Scholar 

  • Deneau G, Yanagita T, Seevers MH (1969) Self-administration of psychoactive substances by the monkey. Psychopharmacologia 16:30–48

    Article  PubMed  CAS  Google Scholar 

  • Deroche-Gamonet V, Belin D, Piazza PV (2004) Evidence for addiction-like behavior in the rat. Science 305:1014–1017

    Article  PubMed  CAS  Google Scholar 

  • Elsmore TF, Fletcher GV, Conrad DG, Sodetz FJ (1980) Reduction of heroin intake in baboons by an economic constraint. Pharmacol Biochem Behav 13:729–731

    Article  PubMed  CAS  Google Scholar 

  • Foltin RW, Fischman MW (1994) Effects of buprenorphine on the self-administration of cocaine by humans. Behav Pharmacol 5:79–89

    Article  PubMed  CAS  Google Scholar 

  • Gardner EL (2000) What we have learned about addiction from animal models of drug self-administration. Am J Addict 9:285–313

    Article  PubMed  CAS  Google Scholar 

  • Herrnstein RJ (1970) On the law of effect. J Exp Anal Behav 13:243–266

    Article  PubMed  CAS  Google Scholar 

  • Hodos W (1961) Progressive ratio as a measure of reward strength. Science 134:943–944

    Article  PubMed  CAS  Google Scholar 

  • Hursh SR (1984) Behavioral economics. J Exp Anal Behav 42:435–452

    Article  PubMed  CAS  Google Scholar 

  • Hursh SR, Silberberg A (2008) Economic demand and essential value. Psychol Rev 115(1):186–198

    Article  PubMed  Google Scholar 

  • Hursh SR, Raslear TG, Bauman R, Black H (1989) The quantitative analysis of economic behavior with laboratory animals. In: Grunert KG, Olander F (eds) Understanding economic behavior. Kluwer Academic, Dordrecht, Netherlands, pp 383–407

    Google Scholar 

  • Kippin TE, Fuchs RA, See RE (2006) Contributions of prolonged contingent and noncontingent cocaine exposure to enhanced reinstatement of cocaine seeking in rats. Psychopharmacology 187:60–67

    Article  PubMed  CAS  Google Scholar 

  • Kitamura O, Wee S, Specio SE, Koob GF, Pulvirenti L (2006) Escalation of methamphetamine self-administration in rats: a dose-effect function. Psychopharmacology 186:48–53

    Article  PubMed  CAS  Google Scholar 

  • Liu Y, Roberts DCS, Morgan D (2005) Effects of extended-access self-administration and deprivation on breakpoints maintained by cocaine in rats. Psychopharmacology 179:644–651

    Article  PubMed  CAS  Google Scholar 

  • Macenski MJ, Meisch RA (1999) Cocaine self-administration under conditions of restricted and unrestricted food access. Exp Clin Psychopharmacol 7:324–337

    Article  PubMed  CAS  Google Scholar 

  • Mantsch JR, Yuferov V, Mathieu-Kia AM, Ho A, Kreek MJ (2004) Effects of extended access to high versus low cocaine doses on self-administration, cocaine-induced reinstatement and brain mRNA levels in rats. Psychopharmacology 175:26–36

    Article  PubMed  CAS  Google Scholar 

  • Nevin JA (1992) An integrative model for the study of behavioral momentum. J Exp Anal Behav 57:301–316

    Article  PubMed  CAS  Google Scholar 

  • Panlilio LV, Weiss SJ, Schindler CW (1996) Cocaine self-administration increased by compounding discriminative stimuli. Psychopharmacology 125:202–208

    Article  PubMed  CAS  Google Scholar 

  • Paterson NE, Markou A (2003) Increased motivation for self-administered cocaine after escalated cocaine intake. NeuroReport 14:2229–2232

    Article  PubMed  CAS  Google Scholar 

  • Pelloux Y, Everitt BJ, Dickinson A (2007) Compulsive drug seeking by rats under punishment: effects of drug taking history. Psychopharmacology 194(1):127–137

    Article  PubMed  CAS  Google Scholar 

  • Perry JL, Morgan AD, Anker JJ, Dess NK, Carroll ME (2006) Escalation of i.v. cocaine self-administration and reinstatement of cocaine-seeking behavior in rats bred for high and low saccharin intake. Psychopharmacology 186:235–245

    Article  PubMed  CAS  Google Scholar 

  • Shahar O, Moscarello JM, Ettenberg A (2006) One hour, but not six hours, of daily access to self-administered cocaine results in elevated levels of the dopamine transporter. Brain Res 1095:148–153

    Article  CAS  Google Scholar 

  • Skinner BF (1932) Drive and reflex strength. J Gen Psych 6:22–37

    Article  Google Scholar 

  • Tsunematsu S (2001) Effort- and time-cost effects on demand curves for food by pigeons under short session closed economies. Behav Processes 53:47–56

    Article  PubMed  Google Scholar 

  • Vanderschuren LJ, Everitt BJ (2004) Drug seeking becomes compulsive after prolonged cocaine self-administration. Science 305:1017–1019

    Article  PubMed  CAS  Google Scholar 

  • Warden CJ (1932) The relative strength of the primary drives in the white rat. Pedagog Semin J Genet Psychol 41:16–35

    Google Scholar 

Download references

Acknowledgment

This research was supported by National Institute on Drug Abuse Grant 1F31DA024493-01 awarded to C.C.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Chesley J. Christensen.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Christensen, C.J., Silberberg, A., Hursh, S.R. et al. Essential value of cocaine and food in rats: tests of the exponential model of demand. Psychopharmacology 198, 221–229 (2008). https://doi.org/10.1007/s00213-008-1120-0

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00213-008-1120-0

Keywords

Navigation