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Impaired platelet [3H]paroxetine binding in female patients with borderline personality disorder

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Abstract

Rationale

There have been few studies of platelet paroxetine binding in borderline personality disorder (BPD).

Objective

Our aim was to determine whether female BPD subjects show abnormalities in platelet paroxetine binding.

Methods

Twenty-one female BPD subjects and 16 age- and gender-matched normal control subjects were assessed using the following: (1) Diagnostic Interview for Borderlines, Revised, (2) Diagnostic Assessment for Personality Pathology: Brief Questionnaire, and (3) Barratt Impulsivity Scale. Platelets were collected and assayed for platelet paroxetine binding.

Results

Bmax was lower in the BPD group (p<0.0001), but differences in Kd only reached a trend level. There were no associations with trait dimensions independent of diagnosis.

Conclusions

Reduced platelet paroxetine binding in female BPD patients may reflect presynaptic serotonin dysfunction.

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References

  • American Psychiatric Association (2000) Diagnostic and statistical manual of mental disorders, text edition, 4th edn. American Psychiatric Press, Washington, DC

    Google Scholar 

  • Bakish D, Cavazonni P, Chudzik J, Ravindran A, Hrdina PD (1997) Effects of selective serotonin reuptake inhibitors on platelet serotonin parameters in major depressive disorder. Biol Psychiatry 41:184–190

    Article  PubMed  CAS  Google Scholar 

  • Barrat E (1985) Impulsive subtraits: arousal and information processing. In: Spence JT, Izard CE (eds) Motivation, emotion, and personality. Elsevier, New York, pp 137–146

    Google Scholar 

  • Brown GL, Ebert MH, Goyer PF (1982) Aggression, suicide and serotonin: relationship to cerebrospinal fluid amine metabolites. Am J Psychiatry 139:741–746

    PubMed  CAS  Google Scholar 

  • Buss AH, Durkee A (1957) An inventory for assessing different kinds of hostility. J Consult Psychol 21:343–349

    Article  PubMed  CAS  Google Scholar 

  • Coccaro EF (1989) Central serotonin and impulsive aggression. Br J Psychiatry Suppl 8:52–62

    PubMed  Google Scholar 

  • Coccaro EF, Kavoussi RJ, Sheline YI, Lish JD, Csernanksy JG (1996) Impulsive aggression in personality disorder correlates with tritiated paroxetine binding in the platelet. Arch Gen Psychiatry 53:531–536

    PubMed  CAS  Google Scholar 

  • DeVegvar M-L, Siever LJ, Trestman RL (1995) Impulsivity and serotonin in borderline personality disorder. In: Silk KR (ed) Biological and neurobehavioral studies of borderline personality disorder. American Psychiatric Press, Washington, DC, pp 23–40

    Google Scholar 

  • Gardner DL, Lucas PB, Cowdry RW (1990) CSF metabolites in borderline personality disorder compared with normal controls. Biol Psychiatry 28:247–254

    Article  PubMed  CAS  Google Scholar 

  • Gardner DL, Leibenluft E, O'Leary KM, Cowdry RW (1991) Self-ratings of hostility and anger in borderline personality disorder. J Nerv Ment Dis 179:157–161

    Article  PubMed  CAS  Google Scholar 

  • Hamilton M (1959) The assessment of anxiety states by rating. Br J Med Psychol 32:50–55

    PubMed  CAS  Google Scholar 

  • Hamilton M (1960) A rating scale for depression. J Neurol Neurosurg Psychiatry 23:56–62

    Article  PubMed  CAS  Google Scholar 

  • Hollingshead A, Redlich F (1958) Social class and mental illness. Wiley, New York

    Google Scholar 

  • Langer SZ, Schoemaker H, Segonzac A (1985) 3H paroxetine binding to human platelets: clues to a selectivity paradox from temperature studies. Br J Pharmacol 96:303–309

    Google Scholar 

  • Leyton M, Okazawa H, Diksic M, Paris J, Rosa P, Mzengeza S, Young SN, Blier P, Benkelfat C (2001) Brain regional rate a—methyl {11} trapping in impulsive subjects with borderline personality disorder. Am J Psychiatry 158:775–782

    Article  PubMed  CAS  Google Scholar 

  • Livesley WJ, Schroeder ML (1991) Dimensions of personality disorder: the DSM-III-R cluster B diagnoses. J Nerv Ment Dis 179:320–328

    Article  Google Scholar 

  • Mann JJ, McBride PA, Anderson GM, Mieczkoswiski TA (1992) Platelet and whole blood serotonin content in depressed inpatients: correlations with acute and life-time psychopathology. Biol Psychiatry 32:243–257

    Article  PubMed  CAS  Google Scholar 

  • Marazziti D, Conti L, Pfanner C, Presta S, Rossi A, Gemignani A, Dell'Osso L, Cassano GB (2001) No correlation between aggression and platelet (3)H-paroxetine binding in obsessive–compulsive disorder patients. Neuropsychobiology 43:117–122

    Article  PubMed  CAS  Google Scholar 

  • Martial J, Paris J, Leyton M, Zweig-Frank H, Schwartz G, Teboul E, Thavuyandil J, Larue S, Ng Ying Kin NMK, Nair NPV (1997) Neuroendocrine study of serotonergic sensitivity in female borderline personality disorder patients. Biol Psychiatry 42:737–739

    Article  PubMed  CAS  Google Scholar 

  • Mellerup ET, Plenge P (1986) High affinity binding of 3H paroxetine and 3H-imipramine to rat neuronal membranes. Psychopharmacology 89:436–439

    Article  PubMed  CAS  Google Scholar 

  • Mellerup ET, Plenge P, Engelsoft M (1983) High affinity binding of 3H paroxetine and 3H-imipramine to human platelet membranes. Eur J Pharmacol 96:303–309

    Article  PubMed  CAS  Google Scholar 

  • Moss HB, Yao JK, Panzak G (1990) Serotonergic responsibility and behavioral dimensions in antisocial personality disorder with substance abuse. Biol Psychiatry 28:325–338

    Article  PubMed  CAS  Google Scholar 

  • Paris J, Zweig-Frank H, Bond M, Guzder J (1996) Defense styles, hostility, and psychological risk factors in male patients with personality disorders. J Nerv Ment Dis 184:155–160

    Article  Google Scholar 

  • Paris J, Zweig-Frank H, Ng Ying Kin NMK, Schwartz G, Steiger H, Nair NPV (2004) Neurobiological correlates of diagnosis and underlying traits in patients with borderline personality disorder compared with normal controls. Psychiatry Res 121:239–252

    Article  PubMed  Google Scholar 

  • Patkar AA, Gottheil E, Berrettini WH, Hill KP, Thornton CC, Weinstein SP (2003) Relationship between platelet serotonin uptake sites and measures of impulsivity, aggression, and craving among African-American cocaine abusers. Am J Addict 12:432–447

    Article  PubMed  Google Scholar 

  • Preuss UW, Soyka M, Bahlmann M, Wenzel K, Behrens S, de Jonge S, Kruger M, Bondy B (2000) Serotonin transporter gene regulatory region polymorphism (5-HTTLPR), [3H]paroxetine binding in healthy control subjects and alcohol-dependent patients and their relationships to impulsivity. Psychiatry Res 96:51–61

    Article  PubMed  CAS  Google Scholar 

  • Rinne T, Westenberg HG, den Boer JA, van den Brink W (2000) Serotonergic blunting to meta-chlorophenylpiperazine (m-CPP) highly correlates with sustained childhood abuse in impulsive and autoaggressive female borderline patients. Biol Psychiatry 47:548–556

    Article  PubMed  CAS  Google Scholar 

  • Rosel P, Menchon JM, Vallejo J, Arranz B, Navarro MA, Liron F, Alvarez P (1997) Platelet [3H]imipramine and [3H]paroxetine binding in depressed patients. J Affect Disord 44:79–85

    Article  PubMed  CAS  Google Scholar 

  • Rosel P, Arranz B, Vallejo J, Alvarez P, Menchon JM, Palencia T, Navarro MA (1999) Altered [3H]imipramine and 5-HT2 but not [3H]paroxetine binding sites in platelets from depressed patients. J Affect Disord 52:225–233

    Article  PubMed  CAS  Google Scholar 

  • Siever LJ, Buchsbaum MS, New AS, Spiegel-Cohen J, Wei T, Hazlett EA, Sevin E, Nunn M, Mitropoulou V (1999) d,l-fenfluramine response in impulsive personality disorder assessed with 18F-fluorodeoxyglcuose positron emission tomography. Neuropychopharmacology 20:413–423

    Article  CAS  Google Scholar 

  • Stahl SM (1985) Platelets as pharmacologica models for the receptors and biochemistry of monoaminergic neurons. In: Longneker GS (ed) Platelets: physiology and pharmacology. Academic, Orlando, FL, pp 340–380

    Google Scholar 

  • Stahl SM, Ciaranello RD, Berger PA (1982) Platelet serotonin in schizophrenia and depression. Adv Biochem Psychopharmacol 34:183–198

    PubMed  CAS  Google Scholar 

  • Steiger H, Leonard S, Ng Ying Kin NM, Ladouceur C, Ramdoyal D, Young SN (2000) Childhood abuse and platelet tritiated-paroxetine binding in bulimia nervosa: implications of borderline personality disorder. J Clin Psychiatry 61:428–435

    Article  PubMed  CAS  Google Scholar 

  • Steiger H, Young SN, Kin NM, Koerner N, Israel M, Lageix P, Lehoux P, Paris J (2001) Implications of impulsive and affective symptoms for serotonin function in bulimia nervosa. Psychol Med 31:85–95

    Article  PubMed  CAS  Google Scholar 

  • Steiger H, Israel M, Gauvin L, Ng Ying Kin NM, Young SN (2003) Implications of compulsive and impulsive traits in women with bulimia nervosa. Psychiatry Res 120:219–229

    Article  PubMed  CAS  Google Scholar 

  • Steiger H, Joober R, Israël M, Young SN, Ng Ying Kin NM, Gauvin L, Bruce KR, Joncas J, Torkamanzehi A (2005) The 5HTTLPR polymorphism, psychopathologic symptoms, and platelet [3H-]paroxetine binding in bulimic syndromes. Int J Eat Disord 37:57–60

    Article  PubMed  Google Scholar 

  • Wood PL, Suranyi-Cadotte BE, Nair NPV, Lafaille F, Schwartz G (1983) Lack of association between 3H imipramine binding sites and uptake of serotonin in control, depressed and schizophrenic patients. Neuropharmacology 22:1211–1214

    Article  PubMed  CAS  Google Scholar 

  • Verkes RJ, Van der Mast RC, Kerkhof AJ, Fekkes D (1998) Platelet serotonin, monoamine oxidase activity, and 3H-paroxetine binding related to impulsive suicide attempts and borderline personality disorder. Biol Psychiatry 43:740–746

    Article  PubMed  CAS  Google Scholar 

  • Zanarini MC, Frankenburg F, Chauncey DL, Gunderson JG (1987) The diagnostic interview for personality disorders: inter-rater and test–retest reliability. Compr Psychiatry 28:467–480

    Article  PubMed  CAS  Google Scholar 

  • Zanarini MC, Gunderson JG, Frankenburg FR (1989) The revised diagnostic interview for borderlines: discriminating BPD from other Axis II disorders. J Personal Disord 3:10–18

    Google Scholar 

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Authors and Affiliations

  1. Department of Psychiatry, McGill University, Montreal, Quebec, Canada

    N. M. K. Ng Ying Kin, Joel Paris, George Schwartz, Howard Steiger & N. P. V. Nair

  2. Douglas Hospital Research Center, Montreal, Quebec, Canada

    N. M. K. Ng Ying Kin, George Schwartz, Howard Steiger & N. P. V. Nair

  3. Institute of Community and Family Psychiatry, SMBD-Jewish General Hospital, Montreal, Quebec, Canada

    Joel Paris

  4. Department of Psychology, Concordia University, Montreal, Quebec, Canada

    Hallie Zweig-Frank

  5. 4333 chemin de la côte ste. Catherine, Montreal, Quebec, Canada, H3T 1E4

    Joel Paris

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  1. N. M. K. Ng Ying Kin
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  2. Joel Paris
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  3. George Schwartz
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  4. Hallie Zweig-Frank
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  5. Howard Steiger
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  6. N. P. V. Nair
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Correspondence to Joel Paris.

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This work was funded by the Medical Research Council of Canada

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Ng Ying Kin, N.M.K., Paris, J., Schwartz, G. et al. Impaired platelet [3H]paroxetine binding in female patients with borderline personality disorder. Psychopharmacology 182, 447–451 (2005). https://doi.org/10.1007/s00213-005-0097-1

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  • DOI: https://doi.org/10.1007/s00213-005-0097-1

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