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Hypericum perforatum: a comprehensive review on pharmacognosy, preclinical studies, putative molecular mechanism, and clinical studies in neurodegenerative diseases

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Abstract

The herb Hypericum perforatum, also referred to as St. John’s wort, has drawn a lot of interest because of its potential therapeutic benefits in treating neurodegenerative illnesses. Due to the absence of effective therapies, illnesses like Alzheimer’s and Parkinson’s disease pose an increasing worldwide health concern. Because of its wide variety of phytochemicals, especially hyperforin, and hypericin, Hypericum perforatum is well known for its neuroprotective properties. These substances have proven to be able to affect different cellular processes linked to neurodegeneration. They can act as anti-inflammatory, antioxidant, and neurotransmitter system regulators, which may help halt neurodegenerative illnesses’ progression. The use of Hypericum perforatum extracts and its contents has shown encouraging results in research on animal models of neurodegenerative disorders. These advantages include higher nerve cell survival, lowered oxidative stress, and higher cognitive performance. Underscoring its versatile potential to combat neurodegeneration, Hypericum perforatum has neuroprotective mechanisms that modulate neuroinflammation and prevent apoptotic pathways. In conclusion, Hypericum perforatum shows tremendous promise as a potential treatment for neurological illnesses due to its wide variety of phytochemicals. To completely comprehend its specific mechanisms of action and turn these discoveries into efficient clinical therapies, additional research is needed. Investigating Hypericum perforatum’s function in neurodegenerative disorders may present new opportunities for the advancement of ground-breaking therapeutic strategies.

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Authors and Affiliations

  1. School of Pharmaceutical Sciences, Jaipur National University, Jaipur, Rajasthan, 302017, India

    Meghraj Vivekanand Suryawanshi

  2. Department of Pharmaceutics and Pharmaceutical Technology, Krishna School of Pharmacy and Research, Drs. Kiran and Pallavi Patel Global University, Varnama, Vadodara, Gujarat, 391240, India

    Meghraj Vivekanand Suryawanshi & Taufik Mulla

  3. AllWell Neuritech LLP, Dharngaon, Maharashtra, 425105, India

    Meghraj Vivekanand Suryawanshi

  4. Department of Pharmacology, Vidhyadeep Institute of Pharmacy, Vidhyadeep University, Anita, Kim, Surat, Gujarat, 394110, India

    Pranjal P. Gujarathi

  5. Centre for Advance Research, Bhagwan Mahavir College of Pharmacy, Bhagwan Mahavir University, Vesu, Surat, Gujarat, 395007, India

    Pranjal P. Gujarathi

  6. Department of Pharmacology, Krishna School of Pharmacy and Research, Drs. Kiran and Pallavi Patel Global University, Varnama, Vadodara, Gujarat, 391240, India

    Imtiyaz Bagban

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Pranjal Gujarathi: conceptualization, investigation, methodology, writing, ori AQ ginal draft, review, and editing. Megharaj Suryavanshi: conceptualization, investigation, writing, and supervision. Taufik Mulla: methodology and review—writing the original draft. Imtiyaz Bagban: methodology and review—writing the original draft. The authors confirm that no paper mill and artificial intelligence was used.

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Suryawanshi, M.V., Gujarathi, P.P., Mulla, T. et al. Hypericum perforatum: a comprehensive review on pharmacognosy, preclinical studies, putative molecular mechanism, and clinical studies in neurodegenerative diseases. Naunyn-Schmiedeberg's Arch Pharmacol (2024). https://doi.org/10.1007/s00210-023-02915-6

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