Abstract
Using selenium (Se) nanoparticles has received attention in recent years because of their therapeutic benefits due to their anticancer, antioxidant, anti-inflammatory, and anti-diabetic effects. This research was conducted to evaluate the possible protective impact of nano-Se on renal unilateral ischemia/reperfusion injury (uIRI) in adult male Wistar rats. Using clamping of the left renal pedicle within 45 min uIRI was induced. The animals were randomly divided into nine groups of control, nano-Se (0.25, 0.5, and 1 mg/kg bw/day) alone, uIRI control, and uIRI rats administrated with nano-Se. At 30 days after treatment, the animals were sacrificed to be assessed biochemically and histopathologically. Nano-Se in uIRI groups have significantly decreased serum creatinine, urea levels, renal histological damage, and increased antioxidant status. Also, our findings demonstrated that the administration of nano-Se caused a significant decrease in the immunoreactivity level of the epidermal growth factor (EGF) and EGFR expression (EGF receptor) in the renal tissue of the uIRI rats. Therefore, nano-Se possesses renoprotective effects, and this effect might be attributable to its antioxidant and free radical scavenger effects. These renoprotective effects may depend on the decreased EGF immunoreactivity level and EGFR expression in the kidney tissue and improve the structure of the kidney tissue. Thus, our research provided biochemical and histological data supporting the potential clinical use of nano-Se for the treatment of certain kidney disorders.
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All data in this study are available from the corresponding author upon request.
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Acknowledgements
The authors are grateful to the Deputy of Research of Science and Research Branch of Islamic Azad University for its support of this research.
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Farzaneh Sadeghmanesh: Visualization, Investigation
Akram Eidi: Conceptualization, Methodology, Writing-Reviewing and Editing, Formal analysis
Pejman Mortazavi: Conceptualization, Methodology, Writing- Reviewing and Editing
Shahrbanoo Oryan: Conceptualization, Methodology
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Sadeghmanesh, F., Eidi, A., Mortazavi, P. et al. Nanoselenium attenuates renal ischemia-reperfusion injury in rats. Naunyn-Schmiedeberg's Arch Pharmacol 397, 2297–2310 (2024). https://doi.org/10.1007/s00210-023-02723-y
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DOI: https://doi.org/10.1007/s00210-023-02723-y