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Association of trabecular bone score (TBS) and prior fracture differs among minorities in NHANES 2005-2008

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Abstract

Summary

The study investigates the association of trabecular bone score (TBS) and fractures among minority populations. In NHANES 2005-2008, TBS was associated with history of fractures in Caucasian subjects but demonstrated somewhat weaker associations in African American and Mexican American women.

Introduction

Trabecular bone score (TBS), a textural analysis of the lumbar spine DXA image, predicts fractures well in Caucasian (CA) and Asian populations but is less well studied in African American (AA) and Mexican American (MA) subjects. It is not clear whether TBS is associated with or is predictive of fragility in these racial/ethnic groups.

Methods

We analyzed data from subjects from NHANES 2005-2008 over the age of 40 who had TBS: 1178 CA, 467 AA, and 397 MA women and 1200 CA, 502 AA, and 386 MA men. TBS was categorized into normal, ≥ 1.310, partially degraded < 1.310, and > 1.230, or degraded, ≤ 1.230. History of fracture was assessed by questionnaire.

Results

Among women, there was an increasing prevalence of fracture with worsening TBS category. However, when controlling for age, BMI, and low T-score, the association between TBS category and previous fracture was only significant in CA women (OR 1.49 per worsening category, 95% CI 1.20–1.85). In men, there was also an increase in the prevalence of fracture with worsening TBS category in all races/ethnicities. When controlling for age, BMI, and low T-score, the association between TBS category and previous fracture was only significant in CA men (OR 1.47 per worsening category, 95% CI 1.10–1.95), though analysis was somewhat limited by small fracture numbers.

Conclusions

The association of fracture and TBS varies by race/ethnicity and gender with weaker association observed in AA and MA women. More research is needed to define the proper use of TBS for predicting fractures in minority groups.

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Authors and Affiliations

  1. Section of Metabolism, Diabetes, and Endocrinology, Lewis Katz School of Medicine at Temple University, 3322 N Broad St, Ste 205, Philadelphia, PA, 19140, USA

    R. K. Jain

  2. Section of Endocrinology, Diabetes, and Metabolism, University of Chicago Medicine, Chicago, IL, 60611, USA

    T. Vokes

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Jain, R.K., Vokes, T. Association of trabecular bone score (TBS) and prior fracture differs among minorities in NHANES 2005-2008. Osteoporos Int 29, 2093–2099 (2018). https://doi.org/10.1007/s00198-018-4584-8

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