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Evaluation of panoramic radiomorphometric indices related to low bone density in sickle cell disease

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Abstract

Summary

In sickle cell disease, erythroid hyperplasia causes trabecular destruction leading to low bone density. This condition could be suspected by the radiomorphometric indices and your diagnosis becomes relevant in a multidisciplinary context of health care for sickle cell subjects, providing prognostics and contributing to determine adequate therapeutic and preventive actions.

Introduction

The aim of this study was to assess the risk of low bone density in subjects with sickle cell disease (SCD) through analysis of panoramic radiographic exams by radiomorphometric indices.

Methods

Seventy-eight Brazilian subjects with SCD took part in this study and were subdivided into four groups: (I) 31 SCD subjects aged under 40 years; (II) 13 SCD subjects aged 40 years or more; (III) 12 normal subjects aged under 40 years; and (IV) 22 normal subjects aged 40 years or more. In the panoramic radiographs, the mandibular cortical index (MCI) classification, increased spacing of the trabecular bone, panoramic mandibular index (PMI), and mental index (MI) were evaluated. Exact Fisher's test was used to compare age between the different groups. Descriptive analysis of the data was performed to evaluate the simple visual estimation of low bone density (increased bone trabecular space and MCI), and a one-way analysis of variance (Bonferroni criteria) was used to compare the means of the quantitative indices (PMI and MI). The significance level was p < 0.05.

Results

In the MCI classification, C2 was more prevalent, especially in groups I and IV. Increased spacing of the trabecular bone was more frequent in groups I and II. MI did not show a statistically significant difference among the groups. PMI showed a statistically significant difference only between groups III and IV.

Conclusions

The radiomorphometric indices applied in the present study can be used on panoramic radiographs to detect the presence of low bone density in SCD subjects.

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Acknowledgments

We are thankful to Professor Marilda Souza Gonçalves, School of Pharmacy—Federal University of Bahia, for carrying out the electrophoresis exams of the subjects and FAPESB (Bahia Research Support Foundation) for the financial support in this study.

Conflicts of interest

None.

Author information

Authors and Affiliations

  1. Department of Oral Diagnosis, Division of Oral Radiology, Piracicaba Dental School, State University of Campinas, Av Limeira, 901, Areião, Piracicaba, São Paulo, Brazil, 13414-018

    F. S. Neves

  2. Department of Oral and Maxillofacial Radiology, School of Dentistry, Federal University of Bahia, Salvador, Bahia, Brazil

    F. S. Neves, L. S. A. F. Oliveira, M. G. G. Torres, P. S. F. Campos & I. Crusoé-Rebello

  3. Department of Pediatrics, Bahia Medical School, Federal University of Bahia, Salvador, Bahia, Brazil

    M. B. P. Toralles

  4. Professor Edgard Santos University Hospital, Federal University of Bahia, Salvador, Bahia, Brazil

    M. C. B. O. da Silva

  5. Department of Biomorphology, Institute of Health Sciences, Federal University of Bahia, Salvador, Bahia, Brazil

    M. I. G. Campos

Authors
  1. F. S. Neves
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  2. L. S. A. F. Oliveira
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  3. M. G. G. Torres
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  4. M. B. P. Toralles
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  5. M. C. B. O. da Silva
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  6. M. I. G. Campos
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  7. P. S. F. Campos
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  8. I. Crusoé-Rebello
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Correspondence to F. S. Neves.

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Neves, F.S., Oliveira, L.S.A.F., Torres, M.G.G. et al. Evaluation of panoramic radiomorphometric indices related to low bone density in sickle cell disease. Osteoporos Int 23, 2037–2042 (2012). https://doi.org/10.1007/s00198-011-1810-z

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  • DOI: https://doi.org/10.1007/s00198-011-1810-z

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