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Nocturnal polyuria in women: results from the EpiNP study

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Abstract

Introduction and hypothesis

Data from a large US population-based, cross-sectional, epidemiological study (the EpiNP Study) were used to assess the symptoms and bother experienced by women with nocturnal polyuria (NP).

Methods

Consenting participants recruited from an online panel completed the baseline EpiNP survey online (Lower Urinary Tract Symptoms Tool and urological comorbidities). All reporting ≥2 voids/night and a random sample of 100 respondents, each reporting 0 or 1 void/night were asked to complete a 3-day web-based bladder diary recording time, volume, and urgency rating of each void. NP was calculated by the proportion of urine production that occurred during nocturnal hours using a Nocturnal Polyuria Index (NPI33) threshold of >0.33 or nocturnal urine production of >90 ml/h (NUP90). The frequency of participants reporting LUTS and bother was determined by age and NP: idiopathic NP, NP associated with overactive bladder (NPOAB), NP associated with comorbidities (NPCom), and no NP (did not meet NP criteria).

Results

A total of 5,290 women completed the baseline survey. Mean age (range) was 54.9 (30–95) years; 1,841 (34.8%) reported ≥2 nocturnal voids. The prevalence of LUTS increased across the lifespan; however, bother associated with each LUTS decreased with increasing age. The percentage of women rating bother by nocturia episodes ≥2 “> somewhat” ranged from 40.3% to 68.3%, with bother ratings highest in the NPOAB and No NP groups.

Conclusions

NP is prevalent in women with considerable bother and is often associated with other urinary symptoms. Multifactorial causes and potential treatments of NP should be considered, particularly at a later age.

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Acknowledgements

Evidera received funding from Ferring Pharmaceuticals A/S for this project. The authors thank the following Evidera employees: Anne Brooks, BS, for providing project management support during the study; Jun Chen, MS, for conducting the analyses; and Ann Yue, MS, for statistical guidance on the weighting procedures.

Funding

Ferring Pharmaceuticals A/S.

Author information

Authors and Affiliations

  1. Loyola University, Maywood, IL, USA

    Elizabeth R. Mueller

  2. SUNY Downstate Health Sciences University, Brooklyn, NY, USA

    Jeffrey P. Weiss

  3. Franciscus G&V Hospital, Rotterdam, Netherlands

    J. L. H. Ruud Bosch

  4. Weill Cornell Medicine, New York, NY, USA

    Bilal Chughtai

  5. Mid Michigan Health Center, Jackson, MI, USA

    Matt T. Rosenberg

  6. Evidera, Seattle, WA, USA

    Elizabeth D. Bacci

  7. Evidera, Waltham, MA, USA

    Jason C. Simeone

  8. Ferring Pharmaceuticals A/S, Copenhagen, Denmark

    Fredrik L. Andersson & Kristian Juul

  9. Evidera, 7101 Wisconsin Avenue, Suite 1400, Bethesda, MD, 20814, USA

    Karin S. Coyne

  10. University of Sheffield, Sheffield, UK

    Christopher R. Chapple

Authors
  1. Elizabeth R. Mueller
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  2. Jeffrey P. Weiss
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  3. J. L. H. Ruud Bosch
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  4. Bilal Chughtai
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  5. Matt T. Rosenberg
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  6. Elizabeth D. Bacci
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  7. Jason C. Simeone
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  9. Kristian Juul
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  10. Karin S. Coyne
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Contributions

E.R. Mueller, J.P. Weiss, J.L.H. Ruud Bosch, B. Chughtai, M.T. Rosenberg, F.L. Andersson, K. Juul, C.R. Chapple: study design, data review and interpretation, and manuscript writing; E.D. Bacci, J.C. Simeone, K.S. Coyne: study design, data collection, data analysis, review and interpretation, and manuscript writing.

Corresponding author

Correspondence to Karin S. Coyne.

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Conflicts of interest

Elizabeth R. Mueller is a consultant to Ferring Pharmaceuticals, Inc., Butler Snow Pharmaceutical, Ethicon (legal consultation), and UpToDate (author royalties). Jeffrey P. Weiss is a consultant to Ferring Pharmaceuticals, Inc., and the Institute for Bladder and Prostate Research. J.L.H. Ruud Bosch is a consultant to Ferring Pharmaceuticals, Inc. Bilal Chughtai is a consultant to Ferring Pharmaceuticals, Inc., Boston Scientific, Olympus, Medi-Tate, Medeonbio, and Urovant. Matt T. Rosenberg is a consultant to Ferring Pharmaceuticals, Inc., Astellas, Urovant, and Sunovion. Karin S. Coyne and Elizabeth D. Bacci are employed by Evidera, and Jason Simeone was employed at Evidera while the study was being conducted, receiving funding from Ferring Pharmaceuticals, Inc. Fredrik L. Andersson and Kristian Juul are employed by Ferring Pharmaceuticals. Christopher R. Chapple reports disclosures as follows: speaker for Allergan; author for Astellas Pharma; author and consultant to Ferring Pharmaceuticals, Inc., and consultant to Proverum, Symimetic, and Urovant Sciences.

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Mueller, E.R., Weiss, J.P., Bosch, J.L.H.R. et al. Nocturnal polyuria in women: results from the EpiNP study. Int Urogynecol J 34, 1743–1751 (2023). https://doi.org/10.1007/s00192-022-05432-x

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  • DOI: https://doi.org/10.1007/s00192-022-05432-x

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