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Bilateral consecutive rupture of the quadriceps tendon in a man with BstUI polymorphism of the COL5A1 gene

  • Knee
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Knee Surgery, Sports Traumatology, Arthroscopy Aims and scope

Abstract

A genetic component has been implicated in tendinopathies involving tendon rupture. Type V collagen, a quantitatively minor fibrillar collagen which forms heterotypic fibrils with type I collagen, plays a role in the regulation of the size and configuration of fibrils of the much more abundant component type I collagen. To date, no data on the genetic component of bilateral rupture of the quadriceps tendon have been reported. We describe the presence of BstUI polymorphism of the COL5A1 gene in a man with bilateral rupture of the quadriceps tendon. The COL5A1 (the variant rs12722, BstUI RFLP) can be a candidate gene associated with the development of bilateral quadriceps tendon rupture.

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Authors and Affiliations

  1. Department of Orthopaedic and Trauma Surgery, Campus Bio-Medico University, Via Alvaro del Portillo, 200, 00128, Trigoria Rome, Italy

    Umile Giuseppe Longo, Francesco Franceschi & Vincenzo Denaro

  2. Laboratory of Molecular Medicine and Biotechnology, Campus Bio-Medico University, Via Alvaro del Portillo, 21, 00128, Trigoria Rome, Italy

    Vito Fazio & Maria Luana Poeta

  3. Department of Surgical Pathology, Campus Bio-Medico University, Via Alvaro del Portillo, 200, 00128, Trigoria Rome, Italy

    Carla Rabitti

  4. Barts and The London School of Medicine and Dentistry, Institute of Health Sciences Education, Centre for Sports and Exercise Medicine, Mile End Hospital, Queen Mary University of London, 275 Bancroft Road, London, E1 4DG, UK

    Nicola Maffulli

Authors
  1. Umile Giuseppe Longo
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  2. Vito Fazio
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  3. Maria Luana Poeta
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  4. Carla Rabitti
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  5. Francesco Franceschi
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  6. Nicola Maffulli
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  7. Vincenzo Denaro
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Corresponding author

Correspondence to Nicola Maffulli.

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Longo, U.G., Fazio, V., Poeta, M.L. et al. Bilateral consecutive rupture of the quadriceps tendon in a man with BstUI polymorphism of the COL5A1 gene. Knee Surg Sports Traumatol Arthrosc 18, 514–518 (2010). https://doi.org/10.1007/s00167-009-1002-y

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  • DOI: https://doi.org/10.1007/s00167-009-1002-y

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