Skip to main content

Advertisement

Log in

Prevention of upper gastrointestinal bleeding in critical illness

  • Lasting Legacy in Intensive Care Medicine
  • Published:
Intensive Care Medicine Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1

References

  1. Krag M, Perner A, Wetterslev J et al (2015) Prevalence and outcome of gastrointestinal bleeding and use of acid suppressants in acutely ill adult intensive care patients. Intensive Care Med 41:833–845

    Article  CAS  Google Scholar 

  2. Ye Z, Reintam Blaser A, Lytvyn L et al (2020) Gastrointestinal bleeding prophylaxis for critically ill patients: a clinical practice guideline. BMJ 368:16722

    Google Scholar 

  3. Plummer MP, Blaser AR, Deane AM (2014) Stress ulceration: prevalence, pathology and association with adverse outcomes. Crit Care 18:213

    Article  PubMed Central  Google Scholar 

  4. Eddleston JM, Pearson RC, Holland J et al (1994) Prospective endoscopic study of stress erosions and ulcers in critically ill adult patients treated with either sucralfate or placebo. Crit Care Med 22:1949–1954

    Article  CAS  Google Scholar 

  5. Krag M, Marker S, Perner A et al (2018) Pantoprazole in patients at risk for gastrointestinal bleeding in the ICU. N Engl J Med 379:2199–2208

    Article  CAS  Google Scholar 

  6. Cook D, Heyland D, Griffith L et al (1999) Risk factors for clinically important upper gastrointestinal bleeding in patients requiring mechanical ventilation. Canadian Critical Care Trials Group. Crit Care Med 27:2812–7

    Article  CAS  Google Scholar 

  7. Cook DJ, Fuller HD, Guyatt GH et al (1994) Risk factors for gastrointestinal bleeding in critically ill patients. Canadian Critical Care Trials Group. N Engl J Med 330:377–81

    Article  CAS  Google Scholar 

  8. Granholm A, Krag M, Marker S et al (2021) Predictors of gastrointestinal bleeding in adult ICU patients in the SUP-ICU trial. Acta Anaesthesiol Scand 65:792–800

    Article  Google Scholar 

  9. Granholm A, Zeng L, Dionne JC et al (2019) Predictors of gastrointestinal bleeding in adult ICU patients: a systematic review and meta-analysis. Intensive Care Med 45:1347–59

    Article  Google Scholar 

  10. Krag M, Perner A, Wetterslev J et al (2015) Stress ulcer prophylaxis in the intensive care unit: an international survey of 97 units in 11 countries. Acta Anaesthesiol Scand 59:576–585

    Article  CAS  Google Scholar 

  11. Barbateskovic M, Marker S, Granholm A et al (2019) Stress ulcer prophylaxis with proton pump inhibitors or histamin-2 receptor antagonists in adult intensive care patients: a systematic review with meta-analysis and trial sequential analysis. Intensive Care Med 45:143–58

    Article  CAS  Google Scholar 

  12. Wang Y, Ge L, Ye Z et al (2020) Efficacy and safety of gastrointestinal bleeding prophylaxis in critically ill patients: an updated systematic review and network meta-analysis of randomized trials. Intensive Care Med 46:1987–2000

    Article  Google Scholar 

  13. Young PJ, Bagshaw SM, Forbes AB et al (2020) Effect of stress ulcer prophylaxis with proton pump inhibitors vs histamine-2 receptor blockers on in-hospital mortality among ICU patients receiving invasive mechanical ventilation: The PEPTIC Randomized Clinical Trial. JAMA 323:616–626

    Article  CAS  PubMed Central  Google Scholar 

  14. Brown JP, Tazare JR, Williamson E et al (2021) Proton pump inhibitors and risk of all-cause and cause-specific mortality: a cohort study. Br J Clin Pharmacol 87:3150–3161

    Article  CAS  Google Scholar 

  15. Halling CMB, Møller MH, Marker S et al (2022) The effects of pantoprazole vs. placebo on 1-year outcomes, resource use and employment status in ICU patients at risk for gastrointestinal bleeding: a secondary analysis of the SUP-ICU trial. Intensive Care Med 48:426–34

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Morten Hylander Møller.

Ethics declarations

Conflicts of interest

MHM and MK sponsored and coordinated the SUP-ICU trial (NCT02467621). WA was the primary investigator of the REVISE Pilot trial (NCT02290327) and a co-investigator on the REVISE Trial (NCT03374800).

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Krag, M., Alhazzani, W. & Møller, M.H. Prevention of upper gastrointestinal bleeding in critical illness. Intensive Care Med 49, 334–336 (2023). https://doi.org/10.1007/s00134-022-06959-9

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00134-022-06959-9

Navigation